Polydopamine-Based Nanoprobes Application in Optical Biosensing

Polydopamine (PDA), the synthetic counterpart of melanin, is a widely investigated bio-inspired material for its chemical and photophysical properties, and in the last few years, bio-application of PDA and PDA-based materials have had a dramatic increase. In this review, we described PDA application in optical biosensing, exploring its multiple roles as a nanomaterial. In optical sensing, PDA can not only be used for its intrinsic fluorescent and photoacoustic properties as a probe: in some cases, a sample optical signal can be derived by melanin generation in situ or it can be enhanced in another material thanks to PDA modification. The various possibilities of PDA use coupled with its biocompatibility will indeed widen even more its application in optical bioimaging.

Automated summary

In this review, the application of polydopamine (PDA) in optical biosensing is described, exploring its multiple roles as a nanomaterial. PDA can be used as a probe, and its optical signal can be obtained through in-situ melanin generation or enhanced by PDA modification.