4.5 Review

MicroRNA-155 mediates endogenous angiotensin II type 1 receptor regulation: implications for innovative type 2 diabetes mellitus management

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Effects of antidiabetics and exercise therapy on suppressors of cytokine signaling-1, suppressors of cytokine signaling-3, and insulin receptor substrate-1 molecules in diabetes and obesity

Ersin Akarsu et al.

Summary: The pathological destruction of insulin signaling molecules, such as insulin receptor substrate, due to increased suppressors of cytokine signaling molecules, has been demonstrated in experimental diabetes. The contribution of suppressors of cytokine signaling proteins to the development of insulin resistance and the effects of antidiabetic drugs and exercise on these proteins are not clearly known.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2023)

Article Medicine, General & Internal

Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes A Randomized Clinical Trial

Gregory P. Forlenza et al.

Summary: Verapamil can partially preserve pancreatic beta cell function in children and adolescents with newly diagnosed type 1 diabetes, as evidenced by improved stimulated C-peptide secretion at 52 weeks compared with placebo.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2023)

Review Cell Biology

Beauty and the beast: host microRNA-155 versus SARS-CoV-2

K. I. Papadopoulos et al.

Summary: Severe acute respiratory coronavirus 2 (SARS-CoV-2) infection causes mild symptoms or is asymptomatic in young and healthy individuals, possibly due to the protective effects of erythropoietin (EPO). However, in older individuals with comorbidities, a potentially lethal cytokine storm can occur as a result of hyperactive renin-angiotensin aldosterone system (RAAS). MicroRNA-155 (miR-155) plays a critical role in antiviral and cardiovascular functions and its dysregulation may contribute to the severe course of COVID-19.

HUMAN CELL (2023)

Review Endocrinology & Metabolism

AT1 receptor downregulation: A mechanism for improving glucose homeostasis

Diana L. Lopez et al.

Summary: There is a pathophysiological correlation between arterial hypertension and diabetes mellitus due to insulin resistance. Angiotensin-II activation of AT1 receptor leads to sustained vasoconstriction and high blood pressure. Chronic activation of AT1 receptor is also associated with insulin resistance.

WORLD JOURNAL OF DIABETES (2023)

Article Cell Biology

Dissecting miRNA-Gene Networks to Map Clinical Utility Roads of Pharmacogenomics-Guided Therapeutic Decisions in Cardiovascular Precision Medicine

Fani Chatzopoulou et al.

Summary: MicroRNAs play a role in the development of cardiovascular disorders through molecular signaling and cell interactions. It is important to establish genomic signatures to understand the multifactorial correlations and variability in treatment outcomes. Clinically validated miRNA biomarkers and relevant SNPs can enhance patient stratification, improve understanding of underlying mechanisms, guide therapeutic selection, and identify innovative drugs and delivery systems.
Article Infectious Diseases

Allele C (rs5186) of at1r is associated with the severity of COVID-19 in the Ukrainian population

O. Izmailova et al.

Summary: There is an association between A1166C at1r polymorphisms and the severity of COVID-19 in the Ukrainian population. Carriers of the 1166C at1r allele are more likely to have severe disease and require oxygen therapy, possibly due to cardiovascular disorders.

INFECTION GENETICS AND EVOLUTION (2022)

Article Multidisciplinary Sciences

Efficacy and safety of eplerenone treatment for patients with diabetic nephropathy: A meta-analysis

Honglei Hu et al.

Summary: Eplerenone treatment has significant therapeutic effects on patients with diabetic nephropathy, reducing levels of urine protein, systolic blood pressure, and renal fibrosis indicator, without increasing adverse events.

PLOS ONE (2022)

Article Multidisciplinary Sciences

Identification of the shared gene signatures and pathways between sarcopenia and type 2 diabetes mellitus

Shiyuan Huang et al.

Summary: This study reveals that sarcopenia and type 2 diabetes may share similar pathogenesis and provides new biological targets and ideas for early diagnosis and effective treatment of these conditions.

PLOS ONE (2022)

Article Endocrinology & Metabolism

A Randomized Controlled Trial of R-Form Verapamil Added to Ongoing Metformin Therapy in Patients with Type 2 Diabetes

Chih-Yuan Wang et al.

Summary: R-form verapamil (R-Vera) is a novel approach for treating type 2 diabetes mellitus (T2DM), as it can significantly improve glycemic control and enhance the survival of pancreatic beta-cells, with a high level of safety.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Review Cell Biology

Role of miR-155 in inflammatory autoimmune diseases: a comprehensive review

Wang-Dong Xu et al.

Summary: MiR-155, a member of the microRNAs family, plays a critical role in the regulation of gene expression in both innate and adaptive immunity. It is aberrantly expressed in various inflammatory autoimmune diseases and is involved in their development. Inhibition of MiR-155 can alter disease progression or ameliorate symptoms, making it a potential therapeutic target for these diseases.

INFLAMMATION RESEARCH (2022)

Review Genetics & Heredity

Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview

P. A. D. S. Palihaderu et al.

Summary: MicroRNA (miRNA) has the potential to be a therapeutic intervention for Type 2 diabetes mellitus due to its stable presence in humans and animals and its ability to regulate glucose and lipid metabolism. However, there is still a lack of clinical-phase miRNA-based therapeutic approaches for treating this disease. Future research should focus on identifying the possibility of miRNA therapeutics for tackling Type 2 diabetes mellitus.

EPIGENETICS INSIGHTS (2022)

Article Biochemistry & Molecular Biology

Study on the correlation between PPARγ, Aβ1-42, miR-155 and the occurrence and development of diabetes

Lv Zhiping et al.

Summary: The study revealed that the levels of PPAR gamma, A beta 1-42, and miR-155 are closely related to the occurrence and development of diabetes, and can effectively predict the progression of the disease.

CELLULAR AND MOLECULAR BIOLOGY (2021)

Article Endocrinology & Metabolism

Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

Yang Zhou et al.

Summary: Type 2 diabetes mellitus (T2DM) is increasing globally, with its complications, particularly diabetic kidney disease (DKD), also on the rise. Increased levels of tenascin-C (TNC) are associated with UACR and hypertension in T2DM patients. In both a rat model of DKD and rat mesangial cells cultured under high glucose conditions, TNC expression levels were elevated. TNC was found to regulate miR-155-5p expression through the TLR4/NF-kappa B p65 pathway, affecting inflammation and fibrosis processes in DKD.

WORLD JOURNAL OF DIABETES (2021)

Review Peripheral Vascular Disease

A systematic review and meta-analysis of effects of spironolactone on blood pressure, glucose, lipids, renal function, fibrosis and inflammation in patients with hypertension and diabetes

Mengyue Lin et al.

Summary: In patients with hypertension and diabetes, spironolactone significantly reduced blood pressure and urinary albumin, improved fibrosis and inflammation, while slightly increased glycosylated hemoglobin and serum creatinine.

BLOOD PRESSURE (2021)

Article Multidisciplinary Sciences

Angiotensin-converting enzyme inhibitors versus angiotensin II receptor blockers on insulin sensitivity in hypertensive patients: A meta-analysis of randomized controlled trials

Jia Yao et al.

Summary: This meta-analysis found that ACE inhibitors were more effective in improving HOMA-IR compared to ARBs in the long-term intervention group and hypertensive patients with diabetes mellitus subgroup. In addition, the efficacy of ACE inhibitors in improving GIR and ISI composite was significantly better than that of ARBs. However, there were no significant differences between ARBs and ACE inhibitors in QUICKI score, FPG, FPI, SBP, and DBP.

PLOS ONE (2021)

Review Biochemistry & Molecular Biology

Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications

Stanislovas S. Jankauskas et al.

Summary: Substantial evidence suggests that miR-155 plays a crucial role in the pathogenesis of diabetes mellitus and its complications, with clinical studies reporting low levels in T2D patients. It contributes to cellular changes and insulin sensitivity regulation, and dysregulation of miR-155 expression is associated with the development of diabetic complications.

NON-CODING RNA (2021)

Review Endocrinology & Metabolism

Mechanism of increased risk of insulin resistance in aging skeletal muscle

Jian Shou et al.

DIABETOLOGY & METABOLIC SYNDROME (2020)

Review Biochemistry & Molecular Biology

Arginine and Endothelial Function

Jessica Gambardella et al.

BIOMEDICINES (2020)

Article Medicine, General & Internal

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

George L. Bakris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Medicine, General & Internal

MicroRNAs as Biomarkers of Systemic Changes in Response to Endurance Exercise-A Comprehensive Review

Aleksandra Soplinska et al.

DIAGNOSTICS (2020)

Article Multidisciplinary Sciences

Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study

Lina Cai et al.

SCIENTIFIC DATA (2020)

Review Biochemistry & Molecular Biology

MicroRNA-155: A Master Regulator of Inflammation

Guruswamy Mahesh et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2019)

Editorial Material Endocrinology & Metabolism

Understanding the mechanisms of reversal of type 2 diabetes

Roy Taylor et al.

LANCET DIABETES & ENDOCRINOLOGY (2019)

Article Medical Laboratory Technology

Decreased Serum Level of miR-155 is Associated with Obesity and its Related Metabolic Traits

Roya Mahdavi et al.

CLINICAL LABORATORY (2018)

Article Endocrinology & Metabolism

MicroRNA expression profile in plasma from type 1 diabetic patients: Case-control study and bioinformatic analysis

Tais S. Assmann et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Review Medicine, Research & Experimental

Modulation of the renin-angiotensin system in white adipose tissue and skeletal muscle: focus on exercise training

Eliete Dalla Corte Frantz et al.

CLINICAL SCIENCE (2018)

Article Endocrinology & Metabolism

Hyperlipidemia-Induced MicroRNA-155-5p Improves β-Cell Function by Targeting Mafb

Mengyu Zhu et al.

DIABETES (2017)

Article Medicine, Research & Experimental

miR-155 functions downstream of angiotensin II receptor subtype 1 and calcineurin to regulate cardiac hypertrophy

Yong Yang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)

Article Cardiac & Cardiovascular Systems

Angiotensin receptor blockers for prevention of cardiovascular disease: where does the evidence stand?

Flavio Danni Fuchs et al.

OPEN HEART (2015)

Article Cardiac & Cardiovascular Systems

microRNA-155 is inversely associated with severity of coronary stenotic lesions calculated by the Gensini score

Guo-fu Zhu et al.

CORONARY ARTERY DISEASE (2014)

Article Endocrinology & Metabolism

Dysregulated miR-155 Expression in Peripheral Blood Mononuclear Cells from Patients with Type 2 Diabetes

N. E. Corral-Fernandez et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2013)

Article Endocrinology & Metabolism

Preventing β-Cell Loss and Diabetes With Calcium Channel Blockers

Guanlan Xu et al.

DIABETES (2012)

Article Medicine, Research & Experimental

microRNA-155 regulates angiotensin II type 1 receptor expression in umbilical vein endothelial cells from severely pre-eclamptic pregnant women

Weiwei Cheng et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2011)

Article Cardiac & Cardiovascular Systems

MicroRNA Expression Profile in CAD Patients and the Impact of ACEI/ARB

Martina Weber et al.

CARDIOLOGY RESEARCH AND PRACTICE (2011)

Article Biochemistry & Molecular Biology

MicroRNA-155 regulates angiotensin II type 1 receptor expression and phenotypic differentiation in vascular adventitial fibroblasts

Liang Zheng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Review Biochemistry & Molecular Biology

miR-155 gene: A typical multifunctional microRNA

Isabella Faraoni et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Article Medicine, Research & Experimental

Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling

YM Zhan et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)