☆ 4.7 Article

Untargeted Metabolomics Analysis Reveals Toxicity Based on the Sex and Sexual Maturity of Single Low-Dose DEHP Exposure

TOXICS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Environmental Sciences

An insight into sex-specific neurotoxicity and molecular mechanisms of DEHP: A critical review

Yiyun Liu et al.

Summary: DEHP is widely used in various products as an additive to give plastics flexibility. However, its unstable combination with polymer leads to migration into the environment and subsequent human exposure. Studies have shown that DEHP exposure is associated with neurodevelopmental abnormalities and neurological diseases. Mechanisms such as oxidative damage, apoptosis, and signal transduction disorder contribute to neurobehavioral abnormalities and nerve injury caused by DEHP. Exposure to DEHP during critical developmental periods increases the risk of neurobehavioral abnormalities, depression, and autism spectrum disorders, with sex-specific effects that can persist into adulthood and have inter-generational effects. Future investigations should focus on population-scale and model organism studies to produce consistent and convincing results, while emphasizing the importance of mechanism research to better understand the environmental and human health risks of DEHP exposure.

ENVIRONMENTAL POLLUTION (2023)

添加到收藏夹

Article Environmental Sciences

Cumulative health risk in children and adolescents exposed to bis(2-ethylhexyl) phthalate (DEHP)

Xiangyun Gao et al.

Summary: DEHP contamination poses potential health risks for children and adolescents, primarily through dietary and nondietary exposure. Analysis of monitoring data reveals that the general population may face high risks of overexposure to DEHP, particularly schoolchildren aged 6 to 9.

ENVIRONMENTAL RESEARCH (2023)

添加到收藏夹

Article Environmental Sciences

Di(2-ethylhexyl) phthalate disturbs cholesterol metabolism through oxidative stress in rat liver

Gang Li et al.

Summary: This study investigated the effect of DEHP on hepatic cholesterol metabolism and revealed the mechanisms underlying DEHP-induced hepatotoxicity. The results showed that DEHP increased levels of total cholesterol, high-density lipoprotein, and alanine transaminase in the serum, and altered oxidative stress response and cholesterol metabolism pathway in the liver.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2022)

添加到收藏夹

Article Environmental Sciences

DEHP induce cholesterol imbalance via disturbing bile acid metabolism by altering the composition of gut microbiota in rats

Zhen Yu et al.

Summary: DEHP exposure induced cholesterol imbalance in rats, disrupted gut microbiota diversity, increased the ratio of Firmicutes to Bacteroidetes, and activated FXR in the gut, subsequently suppressing bile acid synthesis in the liver.

CHEMOSPHERE (2021)

添加到收藏夹

Review Environmental Sciences

The impact of Di-(2-ethylhexyl) Phthalate and Mono(2-ethylhexyl) Phthalate in placental development, function, and pathophysiology

Luis Daniel Martinez-Razo et al.

Summary: DEHP, considered an endocrine disruptor chemical (EDC), is widely used in the plastic industry and can have negative effects on placental development and function, potentially impacting fetal growth. Research indicates that DEHP and MEHP can impair key processes in placental development and affect various placental functions. Clinical evidence also supports the connection between DEHP exposure and adverse pregnancy outcomes and pathologies.

ENVIRONMENT INTERNATIONAL (2021)

添加到收藏夹

Article Environmental Sciences

Integrated metabolomics and transcriptomics reveal di(2-ethylhexyl) phthalate-induced mitochondrial dysfunction and glucose metabolism disorder through oxidative stress in rat liver

Gang Li et al.

Summary: This study systematically describes the comprehensive mechanisms of long-term DEHP exposure on liver injury and highlights the power of metabolomics and transcriptomics platforms in understanding xenobiotic hepatotoxicity.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

添加到收藏夹

Article Food Science & Technology

Effect of nicotinamide riboside on lipid metabolism and gut microflora-bile acid axis in alcohol-exposed mice

Xiao Yu et al.

Summary: The study showed that NR can improve liver damage and abnormal function in alcohol-exposed mice by regulating lipid metabolism and the gut microflora-bile acid axis.

FOOD SCIENCE & NUTRITION (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Metabolic, reproductive and thyroid effects of bis(2-ethylhexyl) phthalate (DEHP) orally administered to male and female juvenile rats at dose levels derived from children biomonitoring study

Roberta Tassinari et al.

Summary: DEHP, an endocrine disrupter, was studied for its juvenile toxicity, revealing liver and metabolic system as main targets in both sexes, with thyroid issues in female rats and reproductive system effects in males. The study concluded that DEHP exposure during peri-pubertal period can induce sex-specific imbalances, utilizing a juvenile animal model for reliable risk assessment targeted towards children.

TOXICOLOGY (2021)

添加到收藏夹

Article Environmental Sciences

Stereological analysis and transcriptome profiling of testicular injury induced by di-(2-ethylhexyl) phthalate in prepubertal rats

Lindong Han et al.

Summary: DEHP exposure during prepubertal stage can lead to testicular injury, characterized by reduced testicular volume, abnormal hormone levels, and structural damage. Transcriptome profiling identified differential gene expression related to key signaling pathways in response to DEHP exposure.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Perspective and Framework for Developing Sample Type Specific Databases for LC/MS-Based Clinical Metabolomics

Nichole A. Reisdorph et al.

METABOLITES (2020)

添加到收藏夹

Article Food Science & Technology

Hepatotoxicity study of combined exposure of DEHP and ethanol: A comprehensive analysis of transcriptomics and metabolomics

Yongning Li et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

添加到收藏夹

Article Chemistry, Analytical

Identification of metabolic pathway disturbances using multimodal metabolomics in autistic disorders in a Middle Eastern population

Tania Bitar et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Metabolomics analysis of urine from rats administered with long-term, low-dose acrylamide by ultra-performance liquid chromatography-mass spectrometry

Haidan Shi et al.

XENOBIOTICA (2017)

添加到收藏夹

Article Environmental Sciences

Urinary metabolomic profiling in rats exposed to dietary di(2-ethylhexyl) phthalate (DEHP) using ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS)

Xinwen Dong et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabonomic analysis of quercetin against the toxicity of acrylamide in rat urine

Wei Bao et al.

FOOD & FUNCTION (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

DEHP exposure in utero disturbs sex determination and is potentially linked with precocious puberty in female mice

Yongan Wang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Di (2-ethylhexyl) phthalate exposure during pregnancy disturbs temporal sex determination regulation in mice offspring

Yongan Wang et al.

TOXICOLOGY (2015)

添加到收藏夹

Article Pharmacology & Pharmacy

Di(2-ethylhexyl) phthalate inhibits antral follicle growth, induces atresia, and inhibits steroid hormone production in cultured mouse antral follicles

Patrick R. Hannon et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2015)

添加到收藏夹

Review Toxicology

Reproductive and developmental effects of phthalate diesters in males

Vanessa R. Kay et al.

CRITICAL REVIEWS IN TOXICOLOGY (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat

Yi Lin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2011)

添加到收藏夹

Article Reproductive Biology

Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats

Sofie Christiansen et al.

REPRODUCTIVE TOXICOLOGY (2010)

添加到收藏夹

Article Chemistry, Analytical

Hydrophilic interaction chromatography for mass spectrometric metabonomic studies of urine

Simon Cubbon et al.

ANALYTICAL CHEMISTRY (2007)

添加到收藏夹

Article Andrology

Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats

Ren-Shan Ge et al.

JOURNAL OF ANDROLOGY (2007)

添加到收藏夹

Article Biochemical Research Methods

A comprehensive urinary metabolomic approach for identifying kidney cancer

Tobias Kind et al.

ANALYTICAL BIOCHEMISTRY (2007)

添加到收藏夹

Article Toxicology

Exposure of prepubertal female rats to inhaled di(2-ethylhexyl)phthalate affects the onset of puberty and postpubertal reproductive functions

Mingyue Ma et al.

TOXICOLOGICAL SCIENCES (2006)

添加到收藏夹

Article Chemistry, Analytical

Effect of creatinine and specific gravity normalization techniques on xenobiotic biomarkers in smokers' spot and 24-h urines

DL Heavner et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2006)

添加到收藏夹

Article Andrology

Possible impact of phthalates on infant reproductive health

G Lottrup et al.

INTERNATIONAL JOURNAL OF ANDROLOGY (2006)

添加到收藏夹

Review Public, Environmental & Occupational Health

Phthalates and human health

R Hauser et al.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2005)

添加到收藏夹

Article Toxicology

New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP

HM Koch et al.

ARCHIVES OF TOXICOLOGY (2005)

添加到收藏夹

Article Toxicology

Chronic toxicity of di(2-ethylhexyl)phthalate in rats

RM David et al.

TOXICOLOGICAL SCIENCES (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.