☆ 4.6 Review

Gut microbiota and hypertension: a bibliometric analysis of recent research (2014-2023)

FRONTIERS IN NUTRITION (2023)

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Review Nutrition & Dietetics

Inflammatory Response: A Crucial Way for Gut Microbes to Regulate Cardiovascular Diseases

Wen Wang et al.

Summary: The gut microbiota, as the largest and most complex microflora in the human body, plays a crucial role in human health and disease. Understanding the bidirectional communication between gut microbiota and extra-intestinal organs can lead to better prevention and treatment of diseases. This review focuses on the characteristics of gut microbiota in cardiovascular disease (CVD) and the importance of inflammation regulation during the entire process, as well as discussing strategies for preventing and treating CVD through proper regulation of gut microbiota and its metabolites.

NUTRIENTS (2023)

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Article Microbiology

The dysbiosis gut microbiota induces the alternation of metabolism and imbalance of Th17/Treg in OSA patients

Fei Wang et al.

Summary: The aim of this study was to investigate the alteration in histidine metabolism and Th17/Treg cell imbalance in obstructive sleep apnea (OSA) patients due to changes in the gut microbiota. The results showed an imbalance in the ratio of Firmicutes/Bacteroidetes and an alteration in metabolic pathways in OSA patients. Additionally, an imbalance of Th17/Treg cells was observed in OSA patients.

ARCHIVES OF MICROBIOLOGY (2022)

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Review Immunology

The critical role of short-chain fatty acids in health and disease: A subtle focus on cardiovascular disease-NLRP3 inflammasome-angiogenesis axis

Juan Yao et al.

Summary: This review summarizes the impact of short-chain fatty acids (SCFAs) on cardiovascular disease (CVD) and highlights the interaction between SCFAs and CVD, NLRP3 inflammasome, and angiogenesis.

CLINICAL IMMUNOLOGY (2022)

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Review Public, Environmental & Occupational Health

Risk factors for incident cardiovascular events among adults in low- and middle-income countries: A systematic review and meta-analysis of prospective cohort studies

Mulugeta Molla Birhanu et al.

Summary: This study estimated the population attributable fraction (PAF) of risk factors for cardiovascular events in low- and middle-income countries (LMICs). The results showed that hypertension, current smoking, and diabetes mellitus were important modifiable risk factors associated with incident cardiovascular events. Other risk factors identified included number of children, depression, bone mineral density, and air pollution.

PREVENTIVE MEDICINE (2022)

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Article Microbiology

Berberine Improves Vascular Dysfunction by Inhibiting Trimethylamine-N-oxide via Regulating the Gut Microbiota in Angiotensin II-Induced Hypertensive Mice

Zhichao Wang et al.

Summary: This study demonstrates that berberine treatment can alleviate vascular dysfunction and high blood pressure in hypertension by regulating gut microbiota, specifically inhibiting the production of TMAO, a harmful substance. These findings highlight the importance of gut microbiota in hypertension and the potential therapeutic role of berberine.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Pharmacology & Pharmacy

Inhibition of Microbiota-dependent Trimethylamine N-Oxide Production Ameliorates High Salt Diet-Induced Sympathetic Excitation and Hypertension in Rats by Attenuating Central Neuroinflammation and Oxidative Stress

Gang Liu et al.

Summary: This study found that long-term high salt diet intake leads to elevated levels of TMAO in the blood and brain, which is associated with increased neuroinflammation and oxidative stress. Inhibiting the generation of TMAO can alleviate sympathetic excitation and hypertension induced by high salt diet.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Knowledge Mapping of the Links Between the Gut Microbiota and Heart Failure: A Scientometric Investigation (2006-2021)

Fei Mu et al.

Summary: This study provides an overview of the link between gut microbiota and heart failure, highlighting the research trends and hotspots in this field. The analysis shows a steady increase in publications and citations, with the United States being the most prolific country. The keywords related to gut microbiota, heart failure, and risk factors emerge as important themes, and new research focuses on trimethylamine N-oxide (TMAO), bile acid, blood pressure, hypertension, and fermentation. Strategies to improve gut microbiota hold promise as a novel approach to treat heart failure.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Chemistry, Applied

Isolation and biological activities of compounds from Rumex vesicarius L. and their use as a component of a synbiotic preparation

Ahmed Elbermawi et al.

Summary: This study evaluated the prebiotic potential and enzyme inhibition of Rumex vesicarius. The roots of R. vesicarius were found to contain compounds that can promote the growth of Escherichia coli and inhibit enzyme activities. These findings suggest that R. vesicarius may serve as a potential prebiotic and have implications for the treatment of diabetes, weight control, and blood pressure regulation.

FOOD CHEMISTRY-X (2022)

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Article Nutrition & Dietetics

In Vitro and In Vivo Antihypertensive Effect of Milk Fermented with Different Strains of Common Starter Lactic Acid Bacteria

Olga A. Glazunova et al.

Summary: Functional dairy products have the potential to prevent essential hypertension, and the search for new strains capable of producing these products is a constant challenge for scientists. In this study, the antihypertensive properties of milk fermented with different strains were assessed, and significant effects were observed for two specific strains both in vitro and in vivo experiments.

NUTRIENTS (2022)

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Review Peripheral Vascular Disease

Short-Chain Fatty Acid Receptors and Blood Pressure Regulation: Council on Hypertension Mid-Career Award for Research Excellence 2021

Jiaojiao Xu et al.

Summary: The gut microbiome, through the production of SCFAs, plays a role in blood pressure regulation and cardiovascular disease. This review discusses the various receptors and signaling pathways involved in SCFA-mediated blood pressure regulation and summarizes the phenotypes observed in knockout mice.

HYPERTENSION (2022)

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Review Physiology

Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome

Lale A. A. Ertuglu et al.

Summary: Salt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease and affects approximately half of the hypertensive population. Recent research suggests that high salt intake can lead to inflammation and hypertension by activating antigen-presenting cells (APCs) and T cells through oxidative stress and NLRP3 inflammasome activation. Understanding these mechanisms could help identify potential therapeutic targets for salt-sensitive hypertension.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Revealing the Pathogenesis of Salt-Sensitive Hypertension in Dahl Salt-Sensitive Rats through Integrated Multi-Omics Analysis

Ya-nan Ou-Yang et al.

Summary: Salt-induced renal metabolism dysfunction is a significant mechanism of salt-sensitive hypertension. This study aimed to investigate the extra-renal mechanism involving hepatic metabolism and gut microbiota, and the potential protective effects of curcumin. The results showed that a high-salt diet led to alterations in hepatic metabolic pathways and changes in gut microbial composition, which were associated with metabolic disorders. The dysfunction in hepatic metabolism was correlated with enhanced lipopolysaccharide (LPS) biosynthesis and apoptosis in gut microbes. Curcumin administration alleviated the salt-induced metabolic dysfunctions and protected against salt-sensitive hypertension.

METABOLITES (2022)

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Article Medicine, General & Internal

Bibliometric and visual analysis of research on the links between the gut microbiota and pain from 2002 to 2021

Menghan Mao et al.

Summary: Research on the links between the gut microbiota and pain has significantly increased since 2016, with a focus on the brain-gut axis and short-chain fatty acid as current research hot spots. The SCFAs-mediated mechanism of pain regulation will be an important research direction in this field.

FRONTIERS IN MEDICINE (2022)

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Review Health Care Sciences & Services

Intestinal Flora Derived Metabolites Affect the Occurrence and Development of Cardiovascular Disease

Yinuo Wen et al.

Summary: Recent evidence suggests that the gut microbiota and their metabolites have a significant impact on human health and diseases, particularly cardiovascular diseases (CVDs). Imbalance in the gut microbiota accelerates the progression of CVDs. Metabolically active products produced by the gut microbiota, such as TMAO, SCFAs, bile acids, tryptophan and indole derivatives, PAGln, and BCAA, participate in the occurrence and development of CVDs by abnormally activating signaling pathways when the integrity of the gut barrier is compromised. This review focuses on the production and metabolism of TMAO and SCFAs, summarizes the roles of gut microbiota metabolites in coronary heart disease, hypertension, pulmonary hypertension, and other CVDs, and discusses the gut-lung axis and gut-heart axis as potential targets for CVD treatment.

JOURNAL OF MULTIDISCIPLINARY HEALTHCARE (2022)

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Article Cardiac & Cardiovascular Systems

A Bibliometric Analysis of Research on the Links Between Gut Microbiota and Atherosclerosis

Ya Wang et al.

Summary: The study analyzed the development of gut microbiota (GM) in atherosclerosis (AS) over the past decades and provided valuable insights. It found a rapid growth in publications on GM in AS since 2008. China and Cleveland Clin were identified as the most prolific country and institution, respectively. The journal with the most publications was Nutrients, while Nature was the most co-cited journal. The research focus in this area has changed over time, with recent studies focusing on choline, hypertension, butyrate, and berberine. The study concluded that GM plays a critical role in atherosclerotic diseases and suggested that this topic deserves more attention in the future.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Nutrition & Dietetics

Hypertension of liver-yang hyperactivity syndrome induced by a high salt diet by altering components of the gut microbiota associated with the glutamate/GABA-glutamine cycle

Tao Zheng et al.

Summary: This study explored the pathogenesis of hypertension caused by a high salt diet by comparing the differences in bacterial community structure, metabolites, and metabolic pathways between rats in a high salt diet-induced hypertension group and a normal group. The results showed that a high salt diet mainly affected the metabolism of amino acids and their derivatives, and promoted hypertension by inhibiting the growth of Clostridiaceae_1 and altering the GABA metabolic pathway.

FRONTIERS IN NUTRITION (2022)

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Review Immunology

Deeper insight into the role of IL-17 in the relationship beween hypertension and intestinal physiology

Ze-Jun Yang et al.

Summary: With the increasing incidence of hypertension worldwide, the relationship between intestinal microbiota and hypertension has gained significant attention. However, the associations between hypertension and a large number of immune factors have not been fully characterized. This review provides a detailed description of the role of IL-17 in the pathology of hypertension, including the underlying mechanisms and clinical implications.

JOURNAL OF INFLAMMATION-LONDON (2022)

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Article Biochemistry & Molecular Biology

Sodium butyrate modulates blood pressure and gut microbiota in maternal tryptophan-free diet-induced hypertension rat offspring

Chien-Ning Hsu et al.

Summary: Maternal nutrition, gut microbiome composition, and metabolites derived from gut microbiota are closely related to the development of hypertension in offspring. Sodium butyrate administration can prevent hypertension induced by a maternal tryptophan-free diet in adult progeny, possibly through modulating gut microbiota, its derived metabolites, and the renin-angiotensin system (RAS).

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

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Review Nutrition & Dietetics

Proteomics Characterization of Food-Derived Bioactive Peptides with Anti-Allergic and Anti-Inflammatory Properties

Ana G. Abril et al.

Summary: Bioactive peptides have various health benefits and can be identified and quantified through proteomics. They have the potential to be a source of novel drugs and ingredients in food and pharmaceuticals.

NUTRIENTS (2022)

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Article Respiratory System

Higher circulating Trimethylamine N-oxide levels are associated with worse severity and prognosis in pulmonary hypertension: a cohort study

Yicheng Yang et al.

Summary: This study investigated the association between plasma TMAO levels and prognosis in patients with PH and found that elevated TMAO levels were associated with severe disease conditions and poor prognosis in patients with PH, suggesting its potential biomarker role in PH.

RESPIRATORY RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Screening and Molecular Mechanisms of Novel ACE-Inhibitory Peptides from Gracilariopsis lemaneiformis

Yongchang Su et al.

Summary: Candidate peptides with novel ACE inhibitor activity were identified from hydrolysates of Gracilariopsis lemaneiformis by virtual screening. These peptides showed significant effects in lowering blood pressure in hypertensive rats, and molecular docking studies revealed their interaction with ACE. Among the peptides, SFYYGK, RLVPVPY, and YIGNNPAKG exhibited potent ACE inhibitory activities and reduced systolic blood pressure in hypertensive rats.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Nutrition & Dietetics

Therapeutic Benefits and Dietary Restrictions of Fiber Intake: A State of the Art Review

Corina-Bianca Ionita-Mindrican et al.

Summary: Fiber intake plays a crucial role in health and high-fiber foods have been shown to reduce the risk of disease. This article provides information on global fiber consumption, fiber metabolism, and the various health benefits associated with fiber intake.

NUTRIENTS (2022)

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Article Biochemistry & Molecular Biology

Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure

Chien-Ning Hsu et al.

Summary: The study found that high-fructose diet and minocycline treatment, both individually and combined, resulted in elevated blood pressure in adult male offspring, with no synergistic effect between the two. Different groups showed distinct enterotypes. Minocycline treatment increased the F/B ratio but decreased the abundance of genera Lactobacillus, Ruminococcus, and Odoribacter. Additionally, minocycline treatment led to lower levels of plasma acetic acid and butyric acid.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biology

Nutritional, antimicrobial and medicinal properties of Camel's milk: A review

Ayman A. Swelum et al.

Summary: Camel's milk is a significant part of staple diet in many regions, rich in health-beneficial substances that can help in the treatment of important human diseases. The composition of camel's milk is influenced by various factors such as feed, breed, age, and lactation stage. Camel's milk contains abundant whey proteins with unique characteristics that are useful in food applications.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Food Science & Technology

Antihypertensive and Probiotic Effects of Hidakakombu (Saccharina angustata) Fermented by Lacticaseibacillus casei 001

Tetsuya Sekine et al.

Summary: Fermentation of low-grade Hidakakombu by Lacticaseibacillus casei 001 enhanced the inhibition of blood pressure elevation, with D-Trp identified as an ACE inhibitory component. This study highlights the potential of using L. casei 001-fermented Hidakakombu as a source of probiotics and functional components against hypertension, adding high value to low-grade kelp.

FOODS (2021)

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Review Urology & Nephrology

The global epidemiology of hypertension

Katherine T. Mills et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Trimethylamine N-oxide and cardiovascular outcomes in patients with chronic heart failure after myocardial infarction

Xiang Zhou et al.

ESC HEART FAILURE (2020)

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Article Cardiac & Cardiovascular Systems

Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

David M. Kaye et al.

CIRCULATION (2020)

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Article Cardiac & Cardiovascular Systems

Associations between gutmicrobiota, faecal short-chain fatty acids, and blood pressure across ethnic groups: the HELIUS study

Barbara J. H. Verhaar et al.

EUROPEAN HEART JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

Associations between gut microbiota, faecal short-chain fatty acids, and blood pressure across ethnic groups: the HELIUS study

Barbara J. H. Verhaar et al.

EUROPEAN HEART JOURNAL (2020)

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Review Clinical Neurology

Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide

Hyo Suk Nam

JOURNAL OF STROKE (2019)

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Article Nutrition & Dietetics

Hypertension Programmed by Perinatal High-Fat Diet: Effect of Maternal Gut Microbiota-Targeted Therapy

Chien-Ning Hsu et al.

NUTRIENTS (2019)

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Review Immunology

The immunology of hypertension

Allison E. Norlander et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

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Article Medicine, Research & Experimental

Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure

Seungbum Kim et al.

CLINICAL SCIENCE (2018)

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Article Geriatrics & Gerontology

Anti-hypertensive peptides released from milk proteins by probiotics

Fatah B. Ahtesh et al.

MATURITAS (2018)

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Article Nutrition & Dietetics

A High Salt Diet Modulates the Gut Microbiota and Short Chain Fatty Acids Production in a Salt-Sensitive Hypertension Rat Model

Ariel Bier et al.

NUTRIENTS (2018)

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Article Peripheral Vascular Disease

Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea

Bhanu P. Ganesh et al.

HYPERTENSION (2018)

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Article Cardiac & Cardiovascular Systems

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice

Francine Z. Marques et al.

CIRCULATION (2017)

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Article Cardiac & Cardiovascular Systems

Hypertension-Linked Pathophysiological Alterations in the Gut

Monica M. Santisteban et al.

CIRCULATION RESEARCH (2017)

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Review Biotechnology & Applied Microbiology

Current Perspectives on Antihypertensive Probiotics

Eric Banan-Mwine Daliri et al.

PROBIOTICS AND ANTIMICROBIAL PROTEINS (2017)

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Article Multidisciplinary Sciences

Salt-responsive gut commensal modulates TH17 axis and disease

Nicola Wilck et al.

NATURE (2017)

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Article Immunology

Alterations of the Gut Microbiome in Hypertension

Qiulong Yan et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

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Article Microbiology

Gut microbiota dysbiosis contributes to the development of hypertension

Jing Li et al.

MICROBIOME (2017)

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Review Peripheral Vascular Disease

Obstructive Sleep Apnea-Induced Hypertension: Role of the Gut Microbiota

David J. Durgan

CURRENT HYPERTENSION REPORTS (2017)

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Article Biochemistry & Molecular Biology

Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion

GuoHua Ma et al.

BIOSCIENCE REPORTS (2017)

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Article Biochemistry & Molecular Biology

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Weifei Zhu et al.

CELL (2016)

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Article Immunology

Chronically Elevated Levels of Short-Chain Fatty Acids Induce T Cell-Mediated Ureteritis and Hydronephrosis

Jeongho Park et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

Plasma Trimethylamine N-Oxide, a Gut Microbe-Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden

Vichai Senthong et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

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Article Cell Biology

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

Niranjana Natarajan et al.

PHYSIOLOGICAL GENOMICS (2016)

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Article Cardiac & Cardiovascular Systems

Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB

Marcus M. Seldin et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

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Article Biochemistry & Molecular Biology

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

Zeneng Wang et al.

CELL (2015)

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Article Peripheral Vascular Disease

Gut Dysbiosis Is Linked to Hypertension

Tao Yang et al.

HYPERTENSION (2015)

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Article Cardiac & Cardiovascular Systems

High salt exacerbates programmed hypertension in maternal fructose-fed male offspring

Y. -L. Tain et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2015)

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Article Cell Biology

Evidence for a link between gut microbiota and hypertension in the Dahl rat

Blair Mell et al.

PHYSIOLOGICAL GENOMICS (2015)

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Article Microbiology

A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome

Shuiming Xiao et al.

FEMS MICROBIOLOGY ECOLOGY (2014)

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Article Endocrinology & Metabolism

Maternal High-Protein or High-Prebiotic-Fiber Diets Affect Maternal Milk Composition and Gut Microbiota in Rat Dams and Their Offspring

Megan C. Hallam et al.

OBESITY (2014)

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Article Multidisciplinary Sciences

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

Markus Kleinewietfeld et al.

NATURE (2013)

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Article Medicine, General & Internal

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

W. H. Wilson Tang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Multidisciplinary Sciences

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

Jennifer L. Pluznick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Computer Science, Interdisciplinary Applications

Software survey: VOSviewer, a computer program for bibliometric mapping

Nees Jan van Eck et al.

SCIENTOMETRICS (2010)

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Article Biochemistry & Molecular Biology

Dietary supplementation of l-carnitine ameliorates metabolic syndrome independent of trimethylamine N-oxide produced by gut microbes in high-fat diet-induced obese mice

Xiang Gao et al.

Summary: This study demonstrated that l-carnitine could effectively alleviate metabolic syndrome induced by a high-fat diet and may be related to its modulation of gut microbiota.

FOOD & FUNCTION

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