Effects of anthocyanin supplementation on blood lipid levels: a systematic review and meta-analysis

Introduction: Dyslipidemia is amajor cardiovascular disease risk factor associated with increasedmortality. The intake of plant food-derived bioactive compounds is associated with beneficial cardiovascular effects, including decreased blood lipid levels and cardiovascular risk. We aimed to evaluate the e ects of anthocyanin intake on blood lipid levels by analyzing relevant randomized controlled trials. Methods: We searched the PubMed and Embase databases using the Patient/Population, Intervention, Comparison, and Outcomes format to determine whether anthocyanin supplementation intervention affected blood lipid levels compared with placebo supplementation in human participants. Results: A total of 41 studies with 2,788 participants were included in the meta-analysis. Anthocyanin supplementation significantly reduced triglyceride [standardized mean difference (SMD) = -0.10; 95% confidence interval [CI], -0.18, -0.01) and low-density lipoprotein-cholesterol (SMD = -0.16; 95% CI -0.26, -0.07) levels and increased high-density lipoprotein-cholesterol levels (SMD = 0.42; 95% CI 0.20, 0.65). Discussion: Anthocyanin supplementation significantly improved blood lipid component levels in the included studies. Larger, well-designed clinical trials are needed to further investigate the e ects of anthocyanin intake on blood lipid levels and the safety of anthocyanin supplementation for treating dyslipidemia.

Automated summary

This study evaluated the effects of anthocyanin intake on blood lipid levels by analyzing relevant randomized controlled trials. The results showed that anthocyanin supplementation significantly reduced triglyceride and low-density lipoprotein-cholesterol levels, and increased high-density lipoprotein-cholesterol levels. However, larger, well-designed clinical trials are needed to further investigate the effects of anthocyanin intake on blood lipid levels and the safety of anthocyanin supplementation for treating dyslipidemia.