期刊
NATURE REVIEWS GENETICS
卷 17, 期 2, 页码 81-92出版社
NATURE PORTFOLIO
DOI: 10.1038/nrg.2015.28
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资金
- University of Idaho College of Natural Resources, USA
- US National Institutes of Health (NIH) [P30 GM103324]
- NSF [1316549]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [R01HD73439]
- National Institute of General Medical Sciences of the National Institutes of Health [R01GM098536]
- US National Science Foundation [DEB-0742181, DEB-1067613]
- NASA [NNX14AB84G]
- Direct For Biological Sciences
- Division Of Environmental Biology [1258203, 1316549] Funding Source: National Science Foundation
High-throughput techniques based on restriction site-associated DNA sequencing (RADseq) are enabling the low-cost discovery and genotyping of thousands of genetic markers for any species, including non-model organisms, which is revolutionizing ecological, evolutionary and conservation genetics. Technical differences among these methods lead to important considerations for all steps of genomics studies, from the specific scientific questions that can be addressed, and the costs of library preparation and sequencing, to the types of bias and error inherent in the resulting data. In this Review, we provide a comprehensive discussion of RADseq methods to aid researchers in choosing among the many different approaches and avoiding erroneous scientific conclusions from RADseq data, a problem that has plagued other genetic marker types in the past.
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