期刊
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
卷 12, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s40164-023-00446-7
关键词
Focal adhesion kinase; Immunotherapy; Combination therapy; Tumor microenvironment
Focal adhesion kinase (FAK) plays a crucial role in cellular functions and tumor microenvironment. Increased FAK expression and activity are strongly associated with unfavorable clinical outcomes and metastatic characteristics in cancer. Modulating FAK activity has potential as an effective approach in cancer therapy.
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital participant in primary cellular functions, such as proliferation, survival, migration, and invasion. In addition, FAK regulates cancer stem cell activities and contributes to the formation of the tumor microenvironment (TME). Importantly, increased FAK expression and activity are strongly associated with unfavorable clinical outcomes and metastatic characteristics in numerous tumors. In vitro and in vivo studies have demonstrated that modulating FAK activity by application of FAK inhibitors alone or in combination treatment regimens could be effective for cancer therapy. Based on these findings, several agents targeting FAK have been exploited in diverse preclinical tumor models. This article briefly describes the structure and function of FAK, as well as research progress on FAK inhibitors in combination therapies. We also discuss the challenges and future directions regarding anti-FAK combination therapies.
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