期刊
NATURE REVIEWS GENETICS
卷 18, 期 2, 页码 71-86出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg.2016.139
关键词
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资金
- US National Institutes of Health [GM77582, GM112972, GM059290, GM114514]
- Howard Hughes Medical Institute postdoctoral fellowship from the Jane Coffin Childs Memorial Fund
- Biomedical Scholars Program of the Pew Charitable Trusts
Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many recent studies reinvigorate the idea that these elements are pervasively co-opted for the regulation of host genes. We argue that the inherent genetic properties of TEs and the conflicting relationships with their hosts facilitate their recruitment for regulatory functions in diverse genomes. We review recent findings supporting the long-standing hypothesis that the waves of TE invasions endured by organisms for eons have catalysed the evolution of gene-regulatory networks. We also discuss the challenges of dissecting and interpreting the phenotypic effect of regulatory activities encoded by TEs in health and disease.
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