4.6 Article

Radiomic signatures from T2W and DWI MRI are predictive of tumour hypoxia in colorectal liver metastases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Integrated Multi-Omics Landscape of Liver Metastases

Shuai Yang et al.

Summary: This study characterized the immune microenvironment subtypes of liver metastases and identified potential mechanisms using mass cytometry, transcriptomic and whole-exome sequencing. Five distinct immune subtypes were identified, and patients with terminally exhausted or rare T-cell-inflamed characteristics showed worse prognosis. Increased intratumor heterogeneity, somatic mutations in TP53, KRAS, APC, and PIK3CA, and hyperactivated hypoxia signaling contributed to the formation of these aggressive subtypes. SLC2A1 was found to promote immune suppression and escape in liver metastatic lesions through interaction with Spp1 thorn macrophages and regulatory T cells, and also played a role in primary colorectal cancer.

GASTROENTEROLOGY (2023)

Article Medicine, Research & Experimental

Targeting FAP alpha-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models

Ming Qi et al.

Summary: This study reveals that vessel co-option mediated by hepatic stellate cells (HSCs) and sinusoidal blood vessels plays a role in the resistance of colorectal cancer liver metastasis (CRCLM) to antiangiogenic therapy. The researchers found that bevacizumab treatment induced hypoxia, resulting in increased expression of fibroblast growth factor-binding protein 1 (FGFBP1) in tumor cells. FGFBP1 then induced fibroblast activation protein alpha (FAP alpha) expression in HSCs, promoting the recruitment of myeloid-derived suppressor cells and the epithelial-mesenchymal transition of tumor cells. Targeting FAP alpha+ HSCs effectively disrupted the co-opted sinusoidal blood vessels and overcame bevacizumab resistance. These findings provide insights into the mechanism of vessel co-option and offer a potential strategy to overcome resistance in CRCLM.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Identifying high-risk colon cancer on CT an a radiomics signature improve radiologist's performance for T staging?

Eun Kyoung Hong et al.

Summary: This study aims to assess the role of radiomics in the detection of high-risk colon cancer and develop a combined model with CT staging. Results show that the combined model of radiomics and CT staging has significantly better performance in detecting high-risk colon tumors.

ABDOMINAL RADIOLOGY (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma

Andrew C. Gordon et al.

Summary: The study used MRI to evaluate changes in tumor hypoxia after Y-90 radioembolization, finding that Y90 treatment may influence tumor oxygenation and that Delta R2* could be a predictive imaging biomarker for tumor response and treatment.

ACADEMIC RADIOLOGY (2021)

Article Gastroenterology & Hepatology

MiR-125b Loss Activated HIF1α/pAKT Loop, Leading to Transarterial Chemoembolization Resistance in Hepatocellular Carcinoma

Xiyang Wei et al.

Summary: miR-125b loss activates the HIF1 alpha/pAKT loop, contributing to HCC resistance to TACE. Key nodes in this axis hold the potential in assisting patients with HCC to choose TACE therapy.

HEPATOLOGY (2021)

Review Oncology

Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy

Bin Wang et al.

Summary: Hypoxic tumor microenvironment (TME) may be a major barrier limiting the efficacy of immunotherapy, through inducing immune suppression and resistance. Targeting hypoxia could enhance the efficacy of immunotherapy and provide a promising combinational therapeutic strategy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Oncology

Restricted Water Diffusion in Diffusion-Weighted Magnetic Resonance Imaging in Pancreatic Cancer is Associated with Tumor Hypoxia

Philipp Mayer et al.

Summary: Pancreatic cancer is characterized by hypoxia, which can be predicted by DW-MRI. Lower random motion of water molecules in cancer lesions may indicate higher levels of hypoxia. DW-MRI is a potential tool for identifying high-risk pancreatic cancer lesions with a high hypoxic fraction.

CANCERS (2021)

Review Oncology

Radiomics for the Prediction of Treatment Outcome and Survival in Patients With Colorectal Cancer: A Systematic Review

Femke C. R. Staal et al.

Summary: Prediction of treatment response and survival in colorectal cancer patients using radiomics is challenging due to heterogeneity, but promising results, particularly with MRI-based methods, suggest potential for accurate predictions. Further research should focus on validating existing models rather than developing new ones.

CLINICAL COLORECTAL CANCER (2021)

Article Multidisciplinary Sciences

A new in vitro model applied 90Y microspheres to study the effects of low dose beta radiation on colorectal cancer cell line in various oxygenation conditions

Piotr Piasecki et al.

Summary: A new in vitro model was proposed to assess the effects of Y-90-microspheres derived low-dose beta radiation on colorectal cancer cells under various oxygenation conditions. The study found that hypoxia induced a higher resistance to radiation, and doses below 70 Gy could reduce colorectal cancer cell proliferation in vitro. This model could be useful for evaluating Y-90 radioembolization effects at the micro-scale.

SCIENTIFIC REPORTS (2021)

Review Medicine, Research & Experimental

A Review of the Role of Hypoxia in Radioresistance in Cancer Therapy

Wafa Bouleftour et al.

Summary: Hypoxia is a crucial factor in tumor cells and a barrier in cancer treatment. Various strategies have been developed to overcome hypoxia-induced radioresistance, but they have shown limited efficacy and may lead to adverse effects.

MEDICAL SCIENCE MONITOR (2021)

Article Oncology

Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck

Dan P. Zandberg et al.

Summary: The study analyzed the effect of anti-PD-1 therapy in patients with recurrent/metastatic squamous cell carcinoma of the head and neck (HNSCC), finding that anti-PD-1 resistance is associated with changes in tumor cell metabolism, increased tumor hypoxia, and decreased CD8+ T cell numbers. Lower tumor hypoxia was associated with increased efficacy of anti-PD-1 therapy in patients.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Development of a Prognostic AI-Monitor for Metastatic Urothelial Cancer Patients Receiving Immunotherapy

Stefano Trebeschi et al.

Summary: The study demonstrates that the AI system PAM can provide prognostic information in advanced urothelial cancer patients receiving immunotherapy, with higher accuracy than current monitoring methods. In multivariate analysis, PAM remains significant against all other methods, suggesting its complementary value in current clinical settings. Further studies are needed to test and validate these findings.

FRONTIERS IN ONCOLOGY (2021)

Article Medicine, General & Internal

Genome-Wide Analysis Reveals Hypoxic Microenvironment Is Associated With Immunosuppression in Poor Survival of Stage II/III Colorectal Cancer Patients

Yu-feng Chen et al.

Summary: A 12-gene signature was identified to predict prognosis of stage II/III CRC patients, with high hypoxic risk correlated with worse prognosis in those without adjuvant chemotherapy. The hypoxia-related gene signature remained an independent prognostic factor, and enrichment analysis revealed suppression of antitumor immune response in the high hypoxic group.

FRONTIERS IN MEDICINE (2021)

Article Computer Science, Artificial Intelligence

Ensemble feature selection for high-dimensional data: a stability analysis across multiple domains

Barbara Pes

NEURAL COMPUTING & APPLICATIONS (2020)

Review Radiology, Nuclear Medicine & Medical Imaging

The clinical utility of imaging methods used to measure hypoxia in cervical cancer

Joseph Waller et al.

BRITISH JOURNAL OF RADIOLOGY (2020)

Article Gastroenterology & Hepatology

Multi-modal radiomics model to predict treatment response to neoadjuvant chemotherapy for locally advanced rectal cancer

Zheng-Yan Li et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

Review Oncology

Hypoxia PET Imaging with [18F]-HX4-A Promising Next-Generation Tracer

Sebastian Sanduleanu et al.

CANCERS (2020)

Review Oncology

Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways

Brita Singers Sorensen et al.

FRONTIERS IN ONCOLOGY (2020)

Review Radiology, Nuclear Medicine & Medical Imaging

Combining molecular and imaging metrics in cancer: radiogenomics

Roberto Lo Gullo et al.

INSIGHTS INTO IMAGING (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Radiogenomics: bridging imaging and genomics

Zuhir Bodalal et al.

ABDOMINAL RADIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop

Ke Xu et al.

MOLECULAR THERAPY (2019)

Article Multidisciplinary Sciences

Radiogenomics-based cancer prognosis in colorectal cancer

Bogdan Badic et al.

SCIENTIFIC REPORTS (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

The Potential Role of Radiomics and Radiogenomics in Patient Stratification by Tumor Hypoxia Status

Loredana G. Marcu et al.

JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY (2019)

Review Computer Science, Artificial Intelligence

Ensembles for feature selection: A review and future trends

Veronica Bolon-Canedo et al.

INFORMATION FUSION (2019)

Article Urology & Nephrology

Visualizing hypoxia

Louise Stone

Nature Reviews Urology (2018)

Article Multidisciplinary Sciences

Radiogenomic analysis of hypoxia pathway is predictive of overall survival in Glioblastoma

Niha Beig et al.

SCIENTIFIC REPORTS (2018)

Article Oncology

Multiparametric High-Resolution MRI as a Tool for Mapping of Hypoxic Level in Tumors

Igor Sersa et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2018)

Article Oncology

Computational Radiomics System to Decode the Radiographic Phenotype

Joost J. M. van Griethuysen et al.

CANCER RESEARCH (2017)

Article Immunology

Tumor hypoxia drives immune suppression and immunotherapy resistance

Midan Ai et al.

Journal for ImmunoTherapy of Cancer (2015)

Review Oncology

Imaging tumour hypoxia with positron emission tomography

I. N. Fleming et al.

BRITISH JOURNAL OF CANCER (2015)

Article Multidisciplinary Sciences

Cholangiocarcinoma: Correlation between Molecular Profiling and Imaging Phenotypes

Eran Sadot et al.

PLOS ONE (2015)

Review Biochemistry & Molecular Biology

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

Joseph C. Walsh et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Cardiac Hypoxia Imaging: Second-Generation Analogues of 64Cu-ATSM

Maxwell G. Handley et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Non-Small Cell Lung Cancer: Histopathologic Correlates for Texture Parameters at CT

Balaji Ganeshan et al.

RADIOLOGY (2013)

Article Radiology, Nuclear Medicine & Medical Imaging

Some thoughts on the mechanism of cellular trapping of Cu(II)-ATSM

Jason L. J. Dearling et al.

NUCLEAR MEDICINE AND BIOLOGY (2010)

Article Oncology

Tumour Hypoxia Affects the Responsiveness of Cancer Cells to Chemotherapy and Promotes Cancer Progression

Jean-Philippe Cosse et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Hypoxia-inducible factor 1 and cancer pathogenesis

Gregg L. Semenza

IUBMB LIFE (2008)