Evaluation of CAP@CS nanoparticles infused cellulose acetate membrane and their invitro antidiabetic, anticancer and antibacterial activity

Cancer drugs with pharmacological activity can be found in many different natural sources. Invitro and invivo research have shown that capsaicin incorporated chitosan nanoparticles (CAP@CS) have anticancer properties. CAP's medicinal potential is limited by its poor water solubility and bioavailability. This research presents the synthesis and characterization of CAP@CS nanoparticles encapsulated in a cellulose acetate membrane (CAP@CS/CA) for potential use in cancer therapy and the treatment of diabetes. The synthesized CAP@CS/CA membrane was analyzed using Scanning Electron Microscopy, Thermogravimetric analysis, mechanical strength testing, and drug release studies. Renal cell carcinoma (ACHN) cancer cell lines were used to test the efficacy of the synthesized CAP@CS/CA membrane in inhibiting tumor growth. These findings point to the synthesized CAP@CS/CA membrane as a potential new therapeutic agent for treating skin cancer and for its antibacterial properties. The capacity of the CAP@CS/CA membrane to inhibit carbohydrate digesting enzymes such aamylase with IC50 values as low as 62.5 mg/mL-1 demonstrates its antidiabetic efficacy. We conclude that the CAP@CS/CA membrane has promising potential antidiabetic potential against important diabetes enzymes and is a perfect nanomedicine for nano-biomedical applications.

Automated summary

Cancer drugs can be found in natural sources, and capsaicin incorporated chitosan nanoparticles have been shown to have anticancer properties. However, their limited water solubility and bioavailability hinder their medicinal potential. This study synthesized and characterized CAP@CS nanoparticles encapsulated in a cellulose acetate membrane for potential use in cancer therapy and diabetes treatment. The synthesized membrane demonstrated efficacy in inhibiting tumor growth and inhibiting carbohydrate digesting enzymes, showing promising potential for cancer and diabetes treatment.