期刊
BIOLOGY-BASEL
卷 12, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biology12091176
关键词
a greater increase in C5aR1 level at onset; a smaller decrease in IgG level after recovery; severer COVID-19 patients; a new analysis with Ishida's t-test1 and t-test2
类别
This study aims to compare the differences in C5aR1 levels at onset and IgG levels after recovery between COVID-19 and non-COVID-19 patients. Using a novel statistical method, the study found that COVID-19 patients had a greater increase in C5aR1 levels at onset and a smaller decrease in IgG levels after recovery.
(1) Background: It is our purpose to identify the differences in the changes in Complement C5a receptor 1 (C5aR1) levels showing the degree of inflammation at onset and Immunoglobulin G (IgG) levels showing the extent of survival of the virus fragments after recovery between coronavirus disease 2019 (COVID-19) and pneumonia coronavirus disease (non-COVID-19) for saving patients' lives. (2) Methods: First, the studies showing these markers' levels in individual patients before and after the passage of time were selected from the PubMed Central (R) databases with the keywords (((COVID-19) AND individual) NOT review) AND C5a/IgG. Then, no changes in these markers' levels with conventional analyses were selected from the studies. Finally, the no changes were reexamined with our new two-tailed t-test using the values on the regression line between initial levels and changed levels instead of the mean or median of changed levels as the expected values of changed levels. (3) Results: Not conventional analyses but our new t-test suggested a greater increase in C5aR1-levels at onset and a smaller decrease in IgG-levels after recovery in COVID-19 patients than non-COVID-19 patients. (4) Conclusion: Our new t-test also should be used in clinics for COVID-19 patients.
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