期刊
BIOLOGY-BASEL
卷 12, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biology12091235
关键词
Trypanosoma cruzi; chagas disease; systemic insecticide; Ross-MacDonald model
类别
Chagas disease, transmitted by triatomines, can cause severe cardiac issues and mortality in mammals. This study assessed the impact of insecticide treatment on dogs in reducing the transmission of Trypanosoma cruzi. The results show that dog treatment can significantly reduce the incidence of T. cruzi infections in humans, but it may increase infections in dogs. A holistic approach targeting different hosts is necessary for Chagas elimination.
Chagas disease, caused by Trypanosoma cruzi and transmitted by triatomines, can lead to severe cardiac issues and mortality in many mammals. Recent studies have shown that systemic insecticide treatment of dogs is highly effective in killing triatomines. Here, we assessed the impact of dog treatment on T. cruzi transmission. We developed a mathematical model of T. cruzi transmission among triatomines, dogs, humans, and rodents. We used the model to evaluate the impact of dog treatment regimens on T. cruzi transmission dynamics to determine their effectiveness in reducing T. cruzi infection among hosts. We show that a 3-month treatment regimen may reduce T. cruzi incidence among humans by 59-80% in a high transmission setting, and 26-82% in a low transmission setting. An annual treatment may reduce incidence among humans by 49-74% in a high transmission setting, and by 11-76% in a low transmission setting. However, dog treatment may substantially increase T. cruzi prevalence among dogs if dog consumption of dead triatomines increases. Our model indicates that dog treatment may reduce T. cruzi infections among humans, but it may increase infections in dogs. Therefore, a holistic approach targeting different hosts is necessary for Chagas elimination.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据