4.6 Article

Association between Combination Antiretroviral Therapy and Telomere Length in People Living with Human Immunodeficiency Virus

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Telomere Shortening in Three Diabetes Mellitus Types in a Mexican Sample

Pavel Cuevas Diaz et al.

Summary: This study aimed to investigate the role of telomere length in three different types of diabetes: latent autoimmune diabetes of adulthood (LADA), latent autoimmune diabetes in the young (LADY), and type 2 diabetes mellitus (T2DM). A total of 115 patients were included, and their telomere length was measured using real-time Polymerase Chain Reaction. The results showed that T2DM patients had higher BMI compared to LADA and LADY groups, while LADA patients had shorter telomeres compared to T2DM patients but not LADY patients. Furthermore, T2DM may have longer telomeres thanks to the protective effects of both metformin and insulin, despite the higher BMI in this group.

BIOMEDICINES (2023)

Article Biochemistry & Molecular Biology

HIV-Tat Exacerbates the Actions of Atazanavir, Efavirenz, and Ritonavir on Cardiac Ryanodine Receptor (RyR2)

Fadhel A. Alomar et al.

Summary: The HIV protein Tat and the antiretroviral drugs atazanavir, efavirenz, and ritonavir can bind to and modulate the activity of RyR2, while other drugs do not have an effect. Low levels of HIV-Tat can enhance the actions of atazanavir and ritonavir, as well as enhance the closing action of efavirenz. Further research is needed to determine if the modulation of RyR2 increases the risk of arrhythmias and sudden cardiac death.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Infectious Diseases

Effects of tenofovir on telomeres, telomerase and T cell maturational subset distribution in long-term aviraemic HIV-infected adults

Javier Rodriguez-Centeno et al.

Summary: This study found that in long-term aviraemic HIV adults, tenofovir can cause telomere shortening in CD8+ T cells by inhibiting telomerase activity, but does not cause telomere shortening in CD4+ T cells. Tenofovir treatment may also lead to a decrease in the proportion of RTE CD4+ cells and a decrease in PD1 marker expression.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

Article Immunology

Telomere Length Declines in Persons With Human Immunodeficiency Virus Before Antiretroviral Therapy Start but Not After Viral Suppression: A Longitudinal Study Over >17 Years

Isabella C. Schoepf et al.

Summary: The study found that there was a significant decline in telomere length during untreated chronic HIV infection, but no significant change during suppressive antiretroviral therapy.

JOURNAL OF INFECTIOUS DISEASES (2022)

Article Biology

Genetic, parental and lifestyle factors influence telomere length

Sergio Andreu-Sanchez et al.

Summary: This study reveals the cell-type-specific differences in telomere biology in humans and its relationship with gene expression, epigenetic signals mediated by parental phenotypes, and expression changes at the single cell level. It confirms the role of perinatal factors in determining telomere lengths, and highlights the influence of genetics, lifestyle, and other factors on this variation.

COMMUNICATIONS BIOLOGY (2022)

Article Pharmacology & Pharmacy

Efavirenz, atazanavir, and ritonavir disrupt sarcoplasmic reticulum Ca2+ homeostasis in skeletal muscles

Fadhel A. Alomar et al.

Summary: The study evaluated the potential impact of antiretroviral drugs on muscle fatigue, pain and weakness in HIV-1 infected individuals by disrupting sarcoplasmic reticulum Ca2+ cycling, suggesting that these drugs may contribute to these co-morbidities through modulation of SR Ca2+ homeostasis.

ANTIVIRAL RESEARCH (2021)

Article Medicine, General & Internal

Serum anti-inflammatory and inflammatory markers have no causal impact on telomere length: a Mendelian randomization study

Mohsen Mazidi et al.

Summary: This study investigated the causal associations between inflammatory markers and telomere length using Mendelian randomization. The results suggest that both anti-inflammatory and pro-inflammatory markers tested did not have any significant causal effect on telomere length. The causal role of bilirubin on telomere length still requires further investigation.

ARCHIVES OF MEDICAL SCIENCE (2021)

Article Geriatrics & Gerontology

Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy

Gordana Dragovic et al.

Summary: This study demonstrated an association between RTL shortening and metabolic syndrome in HIV-infected men, as well as a strong correlation between an increase in metabolic syndrome components and shorter telomere length.

EXPERIMENTAL GERONTOLOGY (2021)

Article Chemistry, Multidisciplinary

Brain-Accumulating Nanoparticles for Assisting Astrocytes to Reduce Human Immunodeficiency Virus and Drug Abuse-Induced Neuroinflammation and Oxidative Stress

Bapurao Surnar et al.

Summary: HIV infection in the brain leads to viral reservoir formation and affects neural protection. Neuroinflammation caused by drug abuse can exacerbate the infection. Current therapies are unable to cross the blood-brain barrier, limiting their effectiveness in treating neural infection.

ACS NANO (2021)

Review Cell Biology

NNRTI and Liver Damage: Evidence of Their Association and the Mechanisms Involved

Ana M. Benedicto et al.

Summary: Improvements in combined antiretroviral therapy have transformed HIV infection into a manageable, chronic condition, but increased risk of non-AIDS-related illnesses, particularly liver-related injury, remains a significant concern for HIV patients. NNRTIs are vital components of anti-HIV treatment, with second-generation NNRTIs generally considered safe for the liver, showing potential hepatoprotective effects.
Article Immunology

Telomere Length Shortening in Microglia: Implication for Accelerated Senescence and Neurocognitive Deficits in HIV

Chiu-Bin Hsiao et al.

Summary: The widespread use of combination antiretroviral therapy (cART) has led to accelerated aging of the HIV-infected population, causing oxidative stress and mitochondrial dysfunction in microglial cells, which may partially explain the occurrence of HIV-associated neurocognitive disorders (HAND).

VACCINES (2021)

Article Endocrinology & Metabolism

Insulin treatment affects leukocyte telomere length in patients with type 2 diabetes: 6-year longitudinal study

Jing-bo Zeng et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2019)

Review Cell Biology

Telomere Biology and Human Phenotype

Kara J. Turner et al.

Article Immunology

Impact of Antiretroviral Treatment Containing Tenofovir Difumarate on the Telomere Length of Aviremic HIV-Infected Patients

Rocio Montejano et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2017)

Article Immunology

Narrowing the Gap in Life Expectancy Between HIV-Infected and HIV-Uninfected Individuals With Access to Care

Julia L. Marcus et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2016)

Article Medicine, Research & Experimental

Association between telomere length and diabetes mellitus: A meta-analysis

Jianfei Wang et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2016)

Article Multidisciplinary Sciences

Persistent HIV-1 replication maintains the tissue reservoir during therapy

Ramon Lorenzo-Redondo et al.

NATURE (2016)

Article Multidisciplinary Sciences

Acceleration of Age-Associated Methylation Patterns in HIV-1-Infected Adults

Tammy M. Rickabaugh et al.

PLOS ONE (2015)

Article Biochemistry & Molecular Biology

The association between statins and telomere shortening

Virginia Boccardi et al.

CLINICAL LIPIDOLOGY (2014)

Review Geriatrics & Gerontology

Gender and telomere length: Systematic review and meta-analysis

Michael Gardner et al.

EXPERIMENTAL GERONTOLOGY (2014)

Article Geriatrics & Gerontology

ELEVATED PLASMA MAGNESIUM AND CALCIUM MAY BE ASSOCIATED WITH SHORTER TELOMERES IN OLDER SOUTH AUSTRALIAN WOMEN

N. J. O'Callaghan et al.

JOURNAL OF NUTRITION HEALTH & AGING (2014)

Article Medicine, Research & Experimental

Efavirenz induces autophagy and aberrant differentiation in normal human keratinocytes

Qinghua Dong et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

Review Medicine, General & Internal

The end of AIDS: HIV infection as a chronic disease

Steven G. Deeks et al.

LANCET (2013)

Review Medicine, Research & Experimental

HIV Infection, Inflammation, Immunosenescence, and Aging

Steven G. Deeks

ANNUAL REVIEW OF MEDICINE, VOL 62, 2011 (2011)

Article Computer Science, Interdisciplinary Applications

Feature Selection with the Boruta Package

Miron B. Kursa et al.

JOURNAL OF STATISTICAL SOFTWARE (2010)

Review Cell Biology

Telomere and adaptive immunity

Nan-ping Weng

MECHANISMS OF AGEING AND DEVELOPMENT (2008)

Article Medical Laboratory Technology

The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool

CC Liew et al.

JOURNAL OF LABORATORY AND CLINICAL MEDICINE (2006)

Article Cardiac & Cardiovascular Systems

C-reactive protein increases oxygen radical generation by neutrophils

K Prasad

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2004)

Article Biochemistry & Molecular Biology

Telomere measurement by quantitative PCR

RM Cawthon

NUCLEIC ACIDS RESEARCH (2002)

Article Medicine, General & Internal

ABC of AIDS - Antiretroviral drugs

IVD Weller et al.

BRITISH MEDICAL JOURNAL (2001)