☆ 4.6 Review

Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19

BIOLOGY-BASEL (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Virology

Human Brain Microvascular Endothelial Cells Exposure to SARS-CoV-2 Leads to Inflammatory Activation through NF-κB Non-Canonical Pathway and Mitochondrial Remodeling

Carolline Soares Motta et al.

Summary: The neurological effects and neuroinvasion of SARS-CoV-2 in COVID-19 are clinically and scientifically relevant. In this study, we investigated the effects of SARS-CoV-2 exposure on human brain microvascular endothelial cells (HBMECs) to understand the mechanisms of viral transmigration across the blood-brain barrier. Although viral replication was low, SARS-CoV-2-exposed cultures exhibited increased apoptotic cell death, tight junction protein expression, and endothelial activation via the NF-κB non-canonical pathway. The secretion of angiogenic factors and mitochondrial dynamics were also altered. These findings suggest that endothelial activation and remodeling contribute to neuroinflammation and increased blood-brain barrier permeability in COVID-19.

VIRUSES-BASEL (2023)

添加到收藏夹

Review Cell Biology

Role of SARS-CoV-2 Spike-Protein-Induced Activation of Microglia and Mast Cells in the Pathogenesis of Neuro-COVID

Theoharis C. Theoharides et al.

Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, and approximately 45% of patients experience long-term fatigue and neurovascular inflammation. The spike protein of SARS-CoV-2 can disrupt the blood-brain barrier, damage neurons, and activate brain mast cells and microglia, resulting in the release of neuroinflammatory molecules. Recent evidence suggests that the flavanol eriodictyol, along with oleuropein and sulforaphane, may be effective in treating COVID-19 and its long-term consequences.

CELLS (2023)

添加到收藏夹

Article Peripheral Vascular Disease

Inflammation and vascular remodeling in COVID-19 hearts

Christopher Werlein et al.

Summary: In this multicentre study, researchers performed a comprehensive analysis of heart samples from autopsies of COVID-19 patients and discovered that cardiac involvement in COVID-19 is a macrophage-driven inflammatory process that is distinct from the typical anti-viral inflammatory responses. The study also found the presence of intussusceptive angiogenesis in the affected hearts, which is a key characteristic of vascular remodeling in COVID-19 pneumonia.

ANGIOGENESIS (2023)

添加到收藏夹

Article Medicine, General & Internal

Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19

Hidde Heesakkers et al.

Summary: The study found that physical, mental, and cognitive symptoms were frequently reported among COVID-19 patients one year after ICU treatment.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

添加到收藏夹

Article Pathology

Modeling SARS-CoV-2: Comparative Pathology in Rhesus Macaque and Golden Syrian Hamster Models

Shambhunath Choudhary et al.

Summary: This study demonstrates that rhesus macaques may be suitable for studying asymptomatic mild COVID-19 pneumonia and COVID-19-associated encephalitis, while Syrian hamsters may be more suited to studying severe COVID-19 pneumonia.

TOXICOLOGIC PATHOLOGY (2022)

添加到收藏夹

Review Microbiology

Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms

Qing Han et al.

Summary: Emerging evidence suggests that COVID-19 survivors may experience persistent symptoms for at least 12 months, including fatigue, dyspnea, arthromyalgia, depression, anxiety, memory loss, concentration difficulties, and insomnia. Female patients and those with more severe initial illness are more likely to suffer from long-term sequelae after one year.

PATHOGENS (2022)

添加到收藏夹

Review Neurosciences

Neurological Sequelae of COVID-19

Samuel J. Ahmad et al.

Summary: COVID-19 infection can lead to various neurological complications such as stroke, psychosis, and encephalopathy, possibly due to mechanisms involving endothelial cell dysfunction, coagulopathy, and inflammation. The pathophysiological mechanisms of these disorders remain unclear.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Markers of endothelial cell activation are associated with the severity of pulmonary disease in COVID-19

William O. Osburn et al.

Summary: The severity of COVID-19 lung disease is associated with elevated levels of von Willebrand Factor (VWF) and soluble P-Selectin (sP-Sel), both released by activated endothelial cells. These biomarkers are also correlated with inflammation and vascular inflammation markers.

PLOS ONE (2022)

添加到收藏夹

Review Immunology

Current Understanding of Long-Term Cognitive Impairment After Sepsis

Ying Li et al.

Summary: Sepsis is a life-threatening condition that can lead to long-term cognitive impairment after hospital discharge. Mechanisms such as blood-brain barrier disruption and neuroinflammation have been proposed for this impairment. Further studies are needed to develop preventive and treatment strategies.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Systematic Analysis of Chemokines Reveals CCL18 is a Prognostic Biomarker in Glioblastoma

Wenqing Gao et al.

Summary: This study reveals that chemokines, including CCL2, CCL8, CCL18, CCL28, CXCL1, CXCL5, and CXCL13, are highly expressed in glioblastoma and are associated with immune cell infiltration regulation and worse patient outcomes. Among them, CCL18 is identified as a critical driver of GBM malignant behaviors.

JOURNAL OF INFLAMMATION RESEARCH (2022)

添加到收藏夹

Article Immunology

SARS-CoV-2 productively infects human brain microvascular endothelial cells

Rui-Cheng Yang et al.

Summary: The study found that SARS-CoV-2 infection can cause dysfunction of the blood-brain barrier, increasing its permeability, which provides new insights into the neuropathogenesis of SARS-CoV-2.

JOURNAL OF NEUROINFLAMMATION (2022)

添加到收藏夹

Review Immunology

The Chemokines CXC, CC and C in the Pathogenesis of COVID-19 Disease and as Surrogates of Vaccine-Induced Innate and Adaptive Protective Responses

Mojgan Noroozi Karimabad et al.

Summary: COVID-19 is a progressive viral pandemic associated with immunological mechanisms. The CC and CXC chemokines play a role in COVID-19 and may reflect the development of reasonable strategies for COVID-19 management.

VACCINES (2022)

添加到收藏夹

Review Neurosciences

Cellular loci involved in the development of brain arteriovenous malformations

Zahra Shabani et al.

Summary: This paper provides an overview of the roles of different cellular loci in the pathogenesis of brain arteriovenous malformations (bAVMs). The formation of bAVMs is associated with gene mutation in endothelial cells (ECs) and angiogenic stimulation. Other than ECs, pericytes, vascular smooth muscle cells (vSMCs), and perivascular astrocytes are also involved in bAVM development. Inflammatory cells play a significant role in the progression and rupture of bAVMs.

FRONTIERS IN HUMAN NEUROSCIENCE (2022)

添加到收藏夹

Letter Cell Biology

SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy

Guanqin Ma et al.

CELL DISCOVERY (2022)

添加到收藏夹

Review Neurosciences

Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19

Daniel Adesse et al.

Summary: COVID-19, caused by SARS-CoV-2, not only affects the lungs but also invades the central nervous system (CNS). This review discusses the interaction between SARS-CoV-2 and the neurovascular units (NVU), the expression of SARS-CoV-2 receptors in CNS cell types, and the impact of aging on the neurological outcomes of COVID-19. Additionally, possible drug therapies to treat neural endothelial function and alleviate COVID-19 neurological symptoms are discussed.

FLUIDS AND BARRIERS OF THE CNS (2022)

添加到收藏夹

Article Geriatrics & Gerontology

Premorbid vulnerability and disease severity impact on Long-COVID cognitive impairment

Viviana Cristillo et al.

Summary: This study found that higher pre-hospitalization National Health System score and more severe pulmonary disease during the acute phase of COVID-19 were associated with abnormal cognitive assessments at 6 months follow-up. The research suggests that age and pre-existing factors may play a role in modulating long-term cognitive consequences in COVID-19 patients.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)

添加到收藏夹

Article Immunology

Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

Mathilde Bellon et al.

Summary: This study analyzed the cerebrospinal fluid features of 31 COVID-19 patients with neurological complications and found no SARS-CoV-2 RNA or intrathecal IgG synthesis, but observed signs of blood-brain barrier disruption. These results may help improve understanding of SARS-CoV-2 related neuropathogenesis.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Immunology

Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study

Jingqi Zhou et al.

Summary: Our study found that patients with pre-existing Alzheimer's disease and dementia are at higher risk of hospital admission due to COVID-19, emphasizing the importance of providing special protective care for these individuals during the pandemic. Additionally, evidence suggests a direct association of genetic variants with COVID-19.

BRAIN BEHAVIOR AND IMMUNITY (2021)

添加到收藏夹

Article Neurosciences

Neurological Complications Associated with the Blood-Brain Barrier Damage Induced by the Inflammatory Response During SARS-CoV-2 Infection

Ivan Alquisiras-Burgos et al.

Summary: The review discusses the potential impacts of SARS-CoV-2 infection on the central nervous system, focusing on the virus's ability to infect brain cells through hematogenous routes and trigger inflammatory responses, which could increase the risk of acquiring neurological diseases.

MOLECULAR NEUROBIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The structural basis of accelerated host cell entry by SARS-CoV-2†

Murat Seyran et al.

Summary: SARS-CoV-2 utilizes its S protein to rapidly enter cells, sliding quickly with the flat sialic acid-binding domain in the N-terminal domain interacting with the epithelial layer, and entering via the ACE-2 receptor. The binding between viral RBD and ACE-2 may be optimal, and protein enzymes can accelerate cell entry by SARS-CoV-2.

FEBS JOURNAL (2021)

添加到收藏夹

Article

Immunotherapies and COVID-19 related Neurological manifestations: A Comprehensive Review Article

Mai M. Anwar

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY (2021)

添加到收藏夹

Review Respiratory System

COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms

Joan Loo et al.

Summary: Thrombotic events in COVID-19, especially venous thromboemboli, are associated with disease severity and poor clinical outcomes. Distinctive microvascular abnormalities include endothelial inflammation, disruption of intercellular junctions, and microthrombi formation. COVID-19 can lead to immunothrombosis, and a better understanding of the pathobiological mechanisms is crucial for developing new treatments.

THORAX (2021)

添加到收藏夹

Editorial Material Psychiatry

The emergence of cognitive COVID

Karen Ritchie et al.

WORLD PSYCHIATRY (2021)

添加到收藏夹

Article Medicine, General & Internal

SARS-CoV-2 leads to a small vessel endotheliitis in the heart

Umberto Maccio et al.

Summary: In COVID-19 patients, there is a strong expression of ACE2/TMPRSS2 and lympho-monocytic inflammation in capillaries, mainly affecting small vessels rather than the main coronaries. Additionally, there is evidence of inflammatory neuropathy in the epicardial nerves, suggesting an angio- and neurotrophic affinity of SARS-COV2 in COVID-19 complications.

EBIOMEDICINE (2021)

添加到收藏夹

Article Immunology

Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: Effect of inflammatory biomarkers at three-month follow-up

Mazza Mario Gennaro et al.

Summary: The mental health implications and cognitive status of COVID-19 pneumonia survivors were prospectively evaluated one and three months after hospital discharge. 35.8% of patients still self-rated symptoms in the clinical range in at least one psychopathological dimension at three months post-discharge. Baseline systemic immune-inflammation index predicted self-rated depressive symptomatology and cognitive impairment at three-months follow-up.

BRAIN BEHAVIOR AND IMMUNITY (2021)

添加到收藏夹

Article Clinical Neurology

Cognitive decline among individuals with history of mild symptomatic SARS-CoV-2 infection: A longitudinal prospective study nested to a population cohort

Oscar H. Del Brutto et al.

Summary: This study provides evidence of cognitive decline among individuals with mild symptomatic SARS-CoV-2 infection. The pathogenesis of this complication remains unknown. Seropositive individuals were found to have a higher risk of cognitive decline compared to seronegative individuals.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Neurological outcome and quality of life 3 months after COVID-19: A prospective observational cohort study

Verena Rass et al.

Summary: Neurological symptoms were prevalent at the 3-month follow-up in COVID-19 patients, with smelling disorders being persistent in a large proportion of patients even after recovery from the acute infection.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Interactions of SARS-CoV-2 with the Blood-Brain Barrier

Michelle A. Erickson et al.

Summary: This review discusses the mechanisms by which SARS-CoV-2 interactions with the blood-brain barrier (BBB) may lead to neurological dysfunction associated with COVID-19. It considers peripheral diseases such as hypoxia and systemic inflammatory response syndrome, as well as CNS infection and viral entry into the brain. Additionally, it explores the contribution of risk factors for severe COVID-19 to BBB dysfunction.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Immunology

Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Tropism in the Lungs, Airways, and Vascular Endothelium of Patients With Fatal Coronavirus Disease 2019: An Autopsy Case Series

Julu Bhatnagar et al.

Summary: This study identified cellular targets of SARS-CoV-2 tropism and replication in various tissues, showing direct infection in the lungs and airways. The research provides important insights into COVID-19 pathogenesis and mechanisms of severe outcomes.

JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Neurosciences

Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients

Joanna Hellmuth et al.

Summary: COVID-19 can lead to persistent neurocognitive symptoms, even in patients with mild symptoms. Studies have shown that some recovering patients experience deficits in working memory and executive functioning. The prolonged cognitive issues may be related to the virus's direct effects, indirect consequences of immune activation, and immune dysregulation leading to auto-antibody production.

JOURNAL OF NEUROVIROLOGY (2021)

添加到收藏夹

Article Neurosciences

Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19

Abhishek Jaywant et al.

Summary: Most COVID-19 patients who require acute rehabilitation prior to discharge exhibit cognitive impairment, with deficits commonly seen in working memory, set-shifting, divided attention, and processing speed. Interventions targeting attention and executive dysfunctions may be beneficial for this population.

NEUROPSYCHOPHARMACOLOGY (2021)

添加到收藏夹

Article Virology

Indications of Persistent Glycocalyx Damage in Convalescent COVID-19 Patients: A Prospective Multicenter Study and Hypothesis

Richard Vollenberg et al.

Summary: This study identifies signs of endothelial damage in convalescent COVID-19 patients after mild disease progression without hospitalization, consistent with studies showing evidence of persistent endothelial damage after severe or critical disease progression. Further research should investigate endothelial damage in convalescent COVID-19 patients.

VIRUSES-BASEL (2021)

添加到收藏夹

Review Psychiatry

Impact of SARS-CoV-2 Infection on Cognitive Function: A Systematic Review

Yazen Alnefeesi et al.

Summary: The prevalence and etiology of cognitive impairment in COVID-19 patients, especially in relation to inflammation and cytokine storms, indicate a significant impact on brain health. High rates of cognitive deficits, primarily delirium, are reported, with inflammatory markers potentially playing a crucial role in mediating these impairments.

FRONTIERS IN PSYCHIATRY (2021)

添加到收藏夹

Review Clinical Neurology

Demyelination as a result of an immune response in patients with COVID-19

Zahra Shabani

Summary: COVID-19, caused by SARS-CoV-2 infection, may lead to neurological complications such as demyelination. There are few reports in the literature about demyelination in COVID-19 patients, but internal immunological dysfunction may be one of the factors contributing to demyelination.

ACTA NEUROLOGICA BELGICA (2021)

添加到收藏夹

Article Biology

Effect of SARS-CoV-2 proteins on vascular permeability

Rossana Rauti et al.

Summary: This study examined the effects of different SARS-CoV-2 proteins on endothelial cells, finding that most of them induced significant changes in endothelial permeability and dysfunction. By analyzing protein-protein interactions, the study predicted the endothelial proteins affected by viral proteins, shedding light on the vascular aspects of COVID-19. Through validation of the protein-protein interaction network model, specific SARS-CoV-2 proteins impacting endothelial function were identified.

ELIFE (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients

Simone R. Potje et al.

Summary: Plasma from COVID-19 patients promotes glycocalyx shedding and redox imbalance in endothelial cells, and heparin treatment potentially inhibits glycocalyx disruption.

LIFE SCIENCES (2021)

添加到收藏夹

Article Clinical Neurology

Long-term neurological manifestations of COVID-19: prevalence and predictive factors

Andrea Pilotto et al.

Summary: Long-term neurological manifestations have been observed in both hospitalised and non-hospitalised COVID-19 patients. Factors such as age, comorbidities, and severity of SARS-CoV-2 infection are independent predictors of long-term neurological symptoms in survivors after 6 months of hospitalisation.

NEUROLOGICAL SCIENCES (2021)

添加到收藏夹

Editorial Material Psychiatry

Psychiatric symptoms and cognitive impairment in Long COVID: the relevance of immunopsychiatry

Brenda W. J. H. Penninx

WORLD PSYCHIATRY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Endothelial glycocalyx shields the interaction of SARS-CoV-2 spike protein with ACE2 receptors

Marta Targosz-Korecka et al.

Summary: Endothelial cells play a crucial role in severe COVID-19 and multiorgan dysfunction, and the susceptibility of ECs to COVID-19 infection may depend on the condition of the glycocalyx.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients

Sofie Bliddal et al.

Summary: Among non-hospitalized PCR-confirmed COVID-19 patients, one third were asymptomatic, while one third of symptomatic participants reported persistent symptoms. Risk factors for persistent symptoms included female sex and BMI.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Endothelial Cell Activation by SARS-CoV-2 Spike S1 Protein: A Crosstalk between Endothelium and Innate Immune Cells

Bianca Maria Rotoli et al.

Summary: This study investigated the effect of the SARS-CoV-2 spike S1 protein on human lung microvascular endothelial cells (HLMVEC), revealing that activation of macrophages by the spike protein can enhance the activation of endothelial cells, potentially contributing to vascular integrity impairment and pro-coagulative endothelium development.

BIOMEDICINES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Zhongnan Qin et al.

Summary: The study found that SARS-CoV-2 infection in K18 mice results in severe COVID-19 symptoms, including body weight loss, lung inflammation, perivascular inflammation, and endothelial dysfunction. The infection also leads to immune activation and vascular abnormalities in the lungs, suggesting a possible link between endotheliitis and severe COVID-19 pathogenesis.

THERANOSTICS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death

Laszlo Szekely et al.

Summary: The main pathology of COVID-19 was found in the lung parenchyma, with a massive accumulation of CD163+ macrophages and the disappearance of other immune cells being the dominant inflammatory response. Lung consolidations were caused by regenerative response, proliferation, and neovascularization.

HELIYON (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Chemokine signaling is required for homeostatic and injury-induced neurogenesis in the olfactory epithelium

Katja Senf et al.

Summary: The olfactory epithelium possesses unique neuroregenerative capacities due to two populations of stem cells - actively dividing GBCs and quiescent HBCs. The expression of CXCR4 distinguishes between these two types of stem cells, playing a crucial role in regulating cell cycle exit and neural differentiation. The CXCR4/CXCL12 signaling pathway is identified as an essential regulator of olfactory neurogenesis, providing new insights into the dynamics of neurogenesis within the OE.

STEM CELLS (2021)

添加到收藏夹

Article Medicine, General & Internal

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

Betty Raman et al.

Summary: The study found that COVID-19 patients discharged from the hospital still experience breathlessness, fatigue, cognitive impairment, and mental health issues. MRI revealed abnormalities in multiple organs, which were linked to inflammation and severity of acute illness.

ECLINICALMEDICINE (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

The incidence of anosmia in patients with laboratory-confirmed COVID 19 infection in India: An observational study

Vinod Kumar et al.

Summary: The study revealed that approximately 30% of COVID-19 patients experience anosmia, with an average duration of about 7.8 days. Most patients recover from anosmia and other symptoms within 2 weeks. Anosmia is significantly associated with ageusia, and eosinophil count plays a role in anosmic patients.

JOURNAL OF ANAESTHESIOLOGY CLINICAL PHARMACOLOGY (2021)

添加到收藏夹

Article Oncology

CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway

Hiroaki Yasui et al.

CLINICAL & EXPERIMENTAL METASTASIS (2020)

添加到收藏夹

Editorial Material Medicine, General & Internal

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

Zunyou Wu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms

Abdul Mannan Baig et al.

ACS CHEMICAL NEUROSCIENCE (2020)

添加到收藏夹

Editorial Material Physiology

Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19

Luca Steardo et al.

ACTA PHYSIOLOGICA (2020)

添加到收藏夹

Letter Immunology

SARS-CoV2 entry and spread in the lymphatic drainage system of the brain

Mehmet Bostanciklioglu

BRAIN BEHAVIOR AND IMMUNITY (2020)

添加到收藏夹

Review Immunology

Nervous system involvement after infection with COVID-19 and other coronaviruses

Yeshun Wu et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The role of angiotensin-converting enzyme 2 in coronaviruses/influenza viruses and cardiovascular disease

Li Chen et al.

CARDIOVASCULAR RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

Qihui Wang et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Medical Laboratory Technology

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

Cynthia Magro et al.

TRANSLATIONAL RESEARCH (2020)

添加到收藏夹

Article Clinical Neurology

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

Ling Mao et al.

JAMA NEUROLOGY (2020)

添加到收藏夹

Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

添加到收藏夹

Article Clinical Neurology

The A4 study: β-amyloid and cognition in 4432 cognitively unimpaired adults

Philip S. Insel et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

Axel Montagne et al.

NATURE (2020)

添加到收藏夹

Letter Medicine, General & Internal

Neurologic Features in Severe SARS-CoV-2 Infection

Julie Helms et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

Keshav K. Singh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

添加到收藏夹

Review Cell Biology

Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality

Santosh Shenoy

INFLAMMATION RESEARCH (2020)

添加到收藏夹

Letter Medicine, General & Internal

Persistent Symptoms in Patients After Acute COVID-19

Angelo Carfi et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Effects of COVID-19 on the Nervous System

Costantino Iadecola et al.

CELL (2020)

添加到收藏夹

Letter Infectious Diseases

Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19

Eve Garrigues et al.

JOURNAL OF INFECTION (2020)

添加到收藏夹

Article Psychiatry

The landscape of cognitive function in recovered COVID-19 patients

Hetong Zhou et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2020)

添加到收藏夹

Article Psychiatry

Impact of COVID-19-Related Lockdown on Psychosocial, Cognitive, and Functional Well-Being in Adults With Down Syndrome

Emanuele Rocco Villani et al.

FRONTIERS IN PSYCHIATRY (2020)

添加到收藏夹

Article Health Care Sciences & Services

Impact of COVID-19 on Alzheimer's Disease Risk: Viewpoint for Research Action

Giulia Abate et al.

HEALTHCARE (2020)

添加到收藏夹

Article Cell & Tissue Engineering

CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement

Henning Ulrich et al.

STEM CELL REVIEWS AND REPORTS (2020)

添加到收藏夹

Article Biology

Interaction of certain monoterpenoid hydrocarbons with the receptor binding domain of 2019 novel coronavirus (2019-nCoV), transmembrane serine protease 2 (TMPRSS2), cathepsin B, and cathepsin L (CatB/L) and their pharmacokinetic properties

Erman Salih Istifli et al.

TURKISH JOURNAL OF BIOLOGY (2020)

添加到收藏夹

Article Clinical Neurology

Frequent neurocognitive deficits after recovery from mild COVID-19

Marcel S. Woo et al.

BRAIN COMMUNICATIONS (2020)

添加到收藏夹

Article Neurosciences

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models

Jean C. Cruz Hernandez et al.

NATURE NEUROSCIENCE (2019)

添加到收藏夹

Review Cell Biology

Development and Cell Biology of the Blood-Brain Barrier

Urs H. Langen et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35 (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

Michelle A. Erickson et al.

PHARMACOLOGICAL REVIEWS (2018)

添加到收藏夹

Article Geriatrics & Gerontology

Blood-Brain Barrier Disruption Induced Cognitive Impairment Is Associated With Increase of Inflammatory Cytokine

Jieli Geng et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

添加到收藏夹

Article Psychiatry

Abnormalities in chemokine levels in schizophrenia and their clinical correlates

Suzi Hong et al.

SCHIZOPHRENIA RESEARCH (2017)

添加到收藏夹

Article Behavioral Sciences

Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation

Jiawen Xu et al.

BEHAVIOURAL BRAIN RESEARCH (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Factors controlling permeability of the blood-brain barrier

Mohammed M. A. Almutairi et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

添加到收藏夹

Review Critical Care Medicine

Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers

Margaret S. Herridge et al.

INTENSIVE CARE MEDICINE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

A complement-microglial axis drives synapse loss during virus-induced memory impairment

Michael J. Vasek et al.

NATURE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism

Arti B. Patel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

添加到收藏夹

Review Medicine, Research & Experimental

Tight junction modulation of the blood brain barrier: CNS delivery of small molecules

Chris Greene et al.

TISSUE BARRIERS (2016)

添加到收藏夹

Article Neurosciences

CCL11 Enhances Excitotoxic Neuronal Death by Producing Reactive Oxygen Species in Microglia

Bijay Parajuli et al.

GLIA (2015)

添加到收藏夹

Article Virology

Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells

Christian Bleau et al.

JOURNAL OF VIROLOGY (2015)

添加到收藏夹

Article Critical Care Medicine

Infection Hospitalization Increases Risk of Dementia in the Elderly

Judith A. Tate et al.

CRITICAL CARE MEDICINE (2014)

添加到收藏夹

Article Physiology

Classical Renin-Angiotensin System in Kidney Physiology

Matthew A. Sparks et al.

COMPREHENSIVE PHYSIOLOGY (2014)

添加到收藏夹

Article Critical Care Medicine

Bidirectional Relationship between Cognitive Function and Pneumonia

Faraaz Ali Shah et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

添加到收藏夹

Article Critical Care Medicine

Cognitive Dysfunction in ICU Patients: Risk Factors, Predictors, and Rehabilitation Interventions

M. Elizabeth Wilcox et al.

CRITICAL CARE MEDICINE (2013)

添加到收藏夹

Article Clinical Neurology

Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

Alexander Semmler et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Pericytes Regulate Vascular Basement Membrane Remodeling and Govern Neutrophil Extravasation during Inflammation

Shijun Wang et al.

PLOS ONE (2012)

添加到收藏夹

Article Critical Care Medicine

Mild Stretch-Induced Injury Increases Susceptibility to Interleukin-1β-Induced Release of Matrix Metalloproteinase-9 from Astrocytes

Hantamalala Ralay Ranaivo et al.

JOURNAL OF NEUROTRAUMA (2011)

添加到收藏夹

Article Multidisciplinary Sciences

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Saul A. Villeda et al.

NATURE (2011)

添加到收藏夹

Article Clinical Neurology

Blood-Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

Yi Yang et al.

STROKE (2011)

添加到收藏夹

Article Clinical Neurology

Blood Brain Barrier Breakdown and Repair by Src after Thrombin-Induced Injury

Da-Zhi Liu et al.

ANNALS OF NEUROLOGY (2010)

添加到收藏夹

Article Medicine, General & Internal

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

Theodore J. Iwashyna et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2010)

添加到收藏夹

Review Neurosciences

The Science of Stroke: Mechanisms in Search of Treatments

Michael A. Moskowitz et al.

NEURON (2010)

添加到收藏夹

Article Neurosciences

Tonic activation of CXC chemokine receptor 4 in immature granule cells supports Neurogenesis in the adult dentate gyrus

Angela Kolodziej et al.

JOURNAL OF NEUROSCIENCE (2008)

添加到收藏夹

Article Clinical Neurology

Neurological signs in relation to type of cerebrovascular disease in vascular dementia

Salka S. Staekenborg et al.

STROKE (2008)

添加到收藏夹

Article Cell Biology

Fibrinogen induces endothelial cell permeability

Neetu Tyagi et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2008)

添加到收藏夹

Article Physiology

Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system

Marc F. Doobay et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)

添加到收藏夹

Article Critical Care Medicine

Long-term neurocognitive function after critical illness

Ramona O. Hopkins et al.

CHEST (2006)

添加到收藏夹

Article Clinical Neurology

White matter lesions in an unselected cohort of the elderly - Molecular pathology suggests origin from chronic hypoperfusion injury

Malee S. Fernando et al.

STROKE (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia

Ertugrul Kilic et al.

FASEB JOURNAL (2006)

添加到收藏夹

Article Physiology

Thrombin and histamine induce stiffening of alveolar epithelial cells

X Trepat et al.

JOURNAL OF APPLIED PHYSIOLOGY (2005)

添加到收藏夹

Article Medicine, Research & Experimental

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein

M Yepes et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

添加到收藏夹

Article Biochemistry & Molecular Biology

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

R Paul et al.

NATURE MEDICINE (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.