☆ 4.6 Review

Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies

BIOLOGY-BASEL (2023)

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Review Biochemistry & Molecular Biology

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

Lei Zhang et al.

Summary: The concept of geroscience focuses on targeting the ageing process itself as a means to improve human health. Cellular senescence, a state of irreversible cell arrest, has emerged as a potential therapeutic target to extend healthspan. Senescent cells develop a secretory phenotype that promotes chronic inflammation and tissue dysfunction. Therapeutic drugs that induce selective cell death of senescent cells or suppress the expression of senescence markers are being developed.

FEBS JOURNAL (2023)

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Review Biochemistry & Molecular Biology

Low-Abundance Protein Enrichment for Medical Applications: The Involvement of Combinatorial Peptide Library Technique

Egisto Boschetti et al.

Summary: The discovery of low- and very low-abundance proteins is crucial in medical applications. To identify these proteins, selective enrichment procedures are necessary. This review discusses the current landscape of enrichment technologies and their applications in identifying early-stage biomarkers for well-known pathologies, as well as detecting host cell protein traces in recombinant therapeutic proteins.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Clinical Neurology

Molecules of senescent glial cells differentiate Alzheimer's disease from ageing

Linbin Dai et al.

Summary: This study identified biomarkers in cerebrospinal fluid (CSF) that can differentiate healthy ageing from neurodegenerative processes, with specific biomarkers being elevated in AD patients. These findings have implications for improving the accuracy of clinical Alzheimer's disease diagnosis and promoting healthy ageing.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2023)

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Article Medicine, General & Internal

Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability

Anoop Nambiar et al.

Summary: This study evaluated the feasibility and tolerability of intermittent administration of dasatinib and quercetin combination therapy in patients with IPF through a randomized placebo-controlled trial. The results showed that the patients completed all doses and assessments under D + Q treatment, and there were no serious adverse events related to the chronic disease or medication.

EBIOMEDICINE (2023)

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Review Medicine, Research & Experimental

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Qian Zhong et al.

Summary: Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent bonds on proteins, which expands protein diversity and contributes to organismal complexity. There are over 650 types of PTMs described to date, including phosphorylation, ubiquitination, glycosylation, methylation, SUMOylation, and various acylation modifications. PTMs can alter protein structure, localization, activity, stability, and interactions, ultimately impacting cell phenotypes and biological processes. Abnormal PTMs are closely related to various diseases. This review introduces the characteristics, regulatory mechanisms, and functions of PTMs in health and diseases, as well as the therapeutic potential in targeting PTMs and associated enzymes for disease treatment.

MEDCOMM (2023)

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Article Multidisciplinary Sciences

Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Madison L. Doolittle et al.

Summary: The article provides a detailed characterization of senescent skeletal cells in vivo, identifying a population of senescent cells associated with age and increased in late osteoblasts/osteocytes and CD24(high) osteolineage cells. The authors also establish CD24 as a marker for skeletal cells cleared by senolytics.

NATURE COMMUNICATIONS (2023)

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Article Biotechnology & Applied Microbiology

Anti-Aging Potential of Platelet Rich Plasma (PRP): Evidence from Osteoarthritis (OA) and Applications in Senescence and Inflammaging

James Vun et al.

Summary: Aging and age-related changes have negative effects on elderly individuals, including decreased movement and cognitive abilities, as well as increased vulnerability to age-related diseases. Cellular senescence, triggered by DNA damage response, is a key factor contributing to these changes. Senescent cells release harmful substances that cause inflammation and contribute to age-related diseases. Platelet-rich plasma (PRP) has shown potential in combating senescence and inflammation, as well as promoting tissue regeneration, making it a promising option for anti-aging and tissue regeneration strategies.

BIOENGINEERING-BASEL (2023)

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Article Medicine, Research & Experimental

DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice

Allison B. Herman et al.

Summary: Senescent vascular smooth muscle cells (VSMCs) secrete dipeptidyl peptidase 4 (DPP4), which increases the levels of complement and coagulation factors, promoting atherosclerotic plaque vulnerability and disease. Inhibiting DPP4 reduces these factors, increases cell death, and improves plaque stability. DPP4-regulated factors could potentially be used therapeutically to reverse senohemostasis and improve vascular disease.

JOURNAL OF CLINICAL INVESTIGATION (2023)

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Review Spectroscopy

Mass spectrometry and the cellular surfaceome

Jarne Pauwels et al.

Summary: The surfaceome, consisting of plasma membrane proteins, plays crucial roles in cell communication, transport regulation, and immune responses. However, challenges such as inefficient extraction and lower abundance compared to intracellular proteins hinder comprehensive analysis. To address these issues, innovative analytical methodologies have been developed.

MASS SPECTROMETRY REVIEWS (2022)

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Article Biochemical Research Methods

Analysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer's disease

Scott B. Laffoon et al.

Summary: This study aims to discover blood-based biomarkers for Alzheimer's disease. The concentration of proteins in plasma was analyzed, and significant changes in plasma proteins associated with AD were found. The findings demonstrate the potential of peripheral protein signatures in characterizing AD.

PROTEOME SCIENCE (2022)

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Article Multidisciplinary Sciences

The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells

Rafael D. Melani et al.

Summary: By studying the proteoforms expressed from human genes in different cell types and bodily fluids, we found that proteoforms provide a better description of protein-level biology and serve as more specific indicators of cell differentiation compared to proteins. In the context of liver transplantation, we utilized the Blood Proteoform Atlas to identify cell and proteoform signatures that distinguish normal graft function from graft dysfunction.

SCIENCE (2022)

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Article Multidisciplinary Sciences

The mTOR inhibitor Rapamycin protects from premature cellular senescence early after experimental kidney transplantation

Uwe Hoff et al.

Summary: This study found that low-dose Rapamycin can prevent premature cellular senescence in the immediate posttransplant period of kidney transplantation, without negative effects on structural and functional recovery. Reduced senescence may maintain renal regenerative capacity and provide protection against future injuries.

PLOS ONE (2022)

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Article Multidisciplinary Sciences

Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano-bio interactions

Shadi Ferdosi et al.

Summary: Exploring plasma proteins on a large scale is challenging, but a multi-nanoparticle workflow proves superior to conventional methods in terms of depth and precision. The physicochemical properties and surface functionalization of nanoparticles are found to affect their selectivity for specific proteins, presenting new possibilities for designing multi-nanoparticle panels in complex biological sample analysis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Medicine, General & Internal

Orally-active, clinically-translatable senolytics restore a-Klotho in mice and humans

Yi Zhu et al.

Summary: This study demonstrates that targeting senescent cells can increase a-Klotho levels in mice and humans, suggesting a potential therapeutic avenue for enhancing a-Klotho. Removing senescent cells can restore a-Klotho expression, offering a translational feasible strategy for developing orally-active small molecule interventions. Urinary a-Klotho may also serve as a useful biomarker for monitoring senolytic clinical trials.

EBIOMEDICINE (2022)

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Article Oncology

Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma

Yexin Tong et al.

Summary: In this study, a comprehensive proteogenomic dataset was utilized to uncover the mechanisms underlying PDAC tumorigenesis and progression, identifying molecular features and therapeutic targets associated with clinical prognosis, and proposing three distinct subtypes of PDAC.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Review Oncology

The diverse functions of FAT1 in cancer progression: good, bad, or ugly?

Zhuo Georgia Chen et al.

Summary: FAT1, one of the most frequently mutated genes in cancer, has potential as a target or prognostic biomarker in cancer treatment. Its function in cancer progression seems to be cancer-type specific and requires further clarification. This review summarizes the recent literature on the role of FAT1 in cancer, including its involvement in cell-cell contact, mitochondrial respiration, and epithelial-mesenchymal transition.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Cellular senescence and senolytics: the path to the clinic

Selim Chaib et al.

Summary: Cellular senescence has emerged as a promising therapeutic target for disorders across the lifespan; targeting persistent senescent cells causing tissue damage may delay, prevent, or alleviate multiple diseases.

NATURE MEDICINE (2022)

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Article Geriatrics & Gerontology

Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study

Roger A. Fielding et al.

Summary: Cellular senescence is associated with age-related declines in physical performance, and senescence biomarkers are significantly correlated with physical function and muscle strength in older adults.

GEROSCIENCE (2022)

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Article Pharmacology & Pharmacy

A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers

Yuqing Meng et al.

Summary: The composition of serum is highly complex, making the discovery of new pharmacodynamic biomarkers challenging. This study developed a nanoparticle-based proteomic analysis strategy to enhance the range of serum proteomic analysis. The strategy successfully identified more proteins and enriched biological processes, providing potential pharmacodynamic biomarkers for disease prediction, diagnosis, and treatment.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2022)

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Article Medicine, General & Internal

Association of Molecular Senescence Markers in Late-Life Depression With Clinical Characteristics and Treatment Outcome

Breno S. Diniz et al.

Summary: This study suggests that the senescence-associated secretory phenotype (SASP) index is associated with the likelihood of remission from a depressive episode in older adults. Combining this index with other biological, clinical, and neuroimaging markers may be useful in evaluating antidepressant treatment outcomes.

JAMA NETWORK OPEN (2022)

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Review Biochemistry & Molecular Biology

Deciphering combinatorial post-translational modifications by top-down mass spectrometry

Jennifer S. Brodbelt

Summary: Post-translational modifications (PTMs) create diversity in proteins and affect their function and regulation. Mass spectrometry analysis allows identification and analysis of PTMs, providing a comprehensive catalog of protein forms. The top-down approach enables in-depth exploration of the impact of combinatorial PTMs on proteins.

CURRENT OPINION IN CHEMICAL BIOLOGY (2022)

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Article Multidisciplinary Sciences

Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities

Ali Akbar Ashkarran et al.

Summary: The analysis of the protein corona formed around nanoparticles is crucial for various applications in nanomedicine. However, the methods used for analysis can affect the results. In this study, the authors investigate the variability of the results obtained from 17 different core facilities. They find considerable heterogeneity in the data retrieved from different facilities, suggesting that protein corona datasets cannot be easily compared across independent studies and compromising the interpretation of protein corona research, with implications in biomarker discovery as well as the safety and efficacy of nanoscale biotechnologies.

NATURE COMMUNICATIONS (2022)

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Article Cardiac & Cardiovascular Systems

Insulin-like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence

Valentina Bracun et al.

Summary: IGFBP7 serves as an independent and robust prognostic biomarker in patients with heart failure, associated with cardiac function and immune system regulation.

ESC HEART FAILURE (2022)

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Review Nutrition & Dietetics

Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging - from theory to practice

Carla Luis et al.

Summary: Aging is a natural process that poses challenges in an aging society, but can be addressed through senotherapeutics and nutritional interventions to delay aging and improve health outcomes.

FRONTIERS IN NUTRITION (2022)

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Review Medicine, Research & Experimental

Connecting aging biology and inflammation in the omics era

Keenan A. Walker et al.

Summary: Aging leads to the accumulation of damage and changes in cell structures, causing a proinflammatory state in blood and solid tissues. Inflammaging is associated with various age-related chronic diseases and loss of physical and cognitive function. Researchers have identified cellular senescence, mitochondrial dysfunction, impaired mitophagy, and DNA damage as potential factors contributing to inflammaging. Multiple omics approaches are being used to understand the complexity of inflammaging and find new therapeutic interventions. Additionally, there is emerging evidence linking inflammation to brain aging and neurodegenerative diseases.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Review Medicine, Research & Experimental

Cellular senescence: a key therapeutic target in aging and diseases

Lei Zhang et al.

Summary: Cellular senescence is a key factor in aging and age-related diseases, and targeting senescent cells has shown promise in preventing tissue damage and promoting tissue repair and regeneration.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Hematology

Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

Takashi Yahata et al.

Summary: Selective blockade of PAI-1 enhances susceptibility of CML-LSC to TKI, facilitating eradication of CML-LSC and sustained remission. Combined therapy of imatinib and PAI-1 inhibitor prevents recurrence of CML-like disease in transplanted recipients, indicating elimination of CML-LSC as a novel therapeutic tactic for CML patients.

HAEMATOLOGICA (2021)

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Review Biochemistry & Molecular Biology

The quest of cell surface markers for stem cell therapy

Anna Meyfour et al.

Summary: Stem cells and their derivatives hold promise for tissue replacement therapy, but their heterogeneous characteristics pose challenges. Targeting specific cell surface markers with antibodies has proven efficient in isolating cell populations, with proteomics playing a key role in identifying these markers. Single cell proteomics and surface markers associated with progenitor stages show potential for use in regenerative medicine.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Pharmacology & Pharmacy

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Paul D. Robbins et al.

Summary: Senescence is a signaling mechanism activated in stressed cells to prevent proliferation of damaged cells, leading to chronic sterile inflammation and age-related diseases. Senescent cells accumulate with age and in diseased anatomical sites, making them a logical therapeutic target. Senotherapeutics, a new class of drugs, selectively kill senescent cells or suppress their disease-causing phenotypes, showing promising results in preclinical studies and clinical trials.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

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Article Biochemical Research Methods

Dynamic Alteration in the Vaginal Secretory Proteome across the Early and Mid-Trimesters of Pregnancy

Bhoj Kumar et al.

Summary: During pregnancy, the proteome dynamics of vaginal fluid show gestational age-specific expression patterns that are associated with tissue remodeling, organ development, and microbial defense.

JOURNAL OF PROTEOME RESEARCH (2021)

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Article Biochemical Research Methods

Assessment of Streptavidin Bead Binding Capacity to Improve Quality of Streptavidin-based Enrichment Studies

Linda Berg Luecke et al.

Summary: The streptavidin-based enrichment of biotin-tagged molecules is commonly used in biomedical research, and there are various immobilized streptavidin formats available. However, predicting the most suitable product for a specific application can be complex due to technical considerations and lack of universal reporting standards. The criteria outlined for evaluating streptavidin beads, along with the AVIDITY assay, provide a useful tool for comparing and assessing binding capacity, benefiting users in making informed decisions for their experiments.

JOURNAL OF PROTEOME RESEARCH (2021)

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Article Biochemical Research Methods

Extending the Depth of Human Plasma Proteome Coverage Using Simple Fractionation Techniques

Gurjeet Kaur et al.

Summary: Human plasma is a commonly used tissue in clinical analysis, with plasma-based biomarkers essential for monitoring patient health status and response to treatment. Plasma proteomics faces challenges due to the complexity of the plasma proteome and the wide quantitative dynamic range. Different fractionation approaches can achieve high plasma proteome coverage, and one-dimensional gel-based prefractionation is effective for parallel sample processing and rapid analysis. Flexibility in method selection based on project-specific needs is crucial for accelerating plasma proteomics research to improve clinical diagnostics and research.

JOURNAL OF PROTEOME RESEARCH (2021)

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Article Allergy

Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammation

Edgar Delgado-Eckert et al.

Summary: The study aimed to evaluate whether subgrouping of patients based on lung function fluctuation patterns can identify specific phenotypes, revealing associations between different fluctuation clusters and clinical severity, exacerbation risk, and quality of life, as well as increased levels of biomarkers related to remodeling and cellular senescence. This fluctuation-based phenotyping provides additional information complementary to clinical diagnosis, unrelated to eosinophilic inflammation, and could help identify patients who may benefit from specific treatment strategies or closer monitoring.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Geriatrics & Gerontology

National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials

Sergei Romashkan et al.

Summary: Cell senescence is linked to various age-related conditions, and there is interest in repurposing drugs to treat these diseases. Future research should focus on finding better and more specific senolytics and senomorphics, as well as implementing standardized measures for data comparison and sharing.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Cell Biology

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

Felice D'Agnillo et al.

Summary: This study identified significant pulmonary pathological features in fatal COVID-19 cases, including progressive diffuse alveolar damage, excessive thrombosis, and delayed pulmonary tissue and vascular remodeling. Acute damage at the alveolar-capillary barrier was characterized by loss of surfactant protein expression and injury to various types of cells, such as alveolar epithelial cells and endothelial cells. These findings provide insights into potential therapeutic targets for treating SARS-CoV-2 infection-induced respiratory distress.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks

Maik Muller et al.

Summary: The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral particles as well as immunosynapse signaling events.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker

Marta Poblocka et al.

Summary: A variety of diseases are influenced by the accumulation of senescent cells, and clearing these cells may prolong lifespan. Existing senolytics lack specificity, suggesting a targeted approach. Using B2M as a target shows promise for specific elimination of senescent cells.

SCIENTIFIC REPORTS (2021)

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Review Microbiology

Post-Translational Modifications Drive Success and Failure of Fungal-Host Interactions

Charmaine Retanal et al.

Summary: This review focuses on the role of post-translational modifications (PTMs) in fungal pathogens, such as Candida spp., Aspergillus spp., and Cryptococcus spp., in adapting to host environments, manipulating host immune responses, and developing resistance to antifungal drugs. It provides a critical evaluation of current knowledge, addresses key questions in understanding the complex roles of PTMs in fungal pathogens, and presents research opportunities for uncovering new therapeutic strategies.

JOURNAL OF FUNGI (2021)

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Review Cell Biology

Proteomics in aging research: A roadmap to clinical, translational research

Ruin Moaddel et al.

Summary: The identification of blood plasma proteins that change with age and predict health deterioration apart from chronological age is a growing research area. These proteins are important for understanding the mechanisms of aging and can potentially lead to the development of new treatments for improving health expectancy.

AGING CELL (2021)

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Article Geriatrics & Gerontology

Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration

Jae-Byoung Chae et al.

Summary: Research shows that eliminating senescent cells in retinal pigment epithelium can alleviate symptoms of age-related macular degeneration, offering a new approach for treating AMD.

GEROSCIENCE (2021)

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Article Biochemical Research Methods

Novel Strategies to Address the Challenges in Top-Down Proteomics

Jake A. Melby et al.

Summary: Top-down proteomics is a powerful technology for comprehensively characterizing proteoforms and understanding protein functions, disease mechanisms, and biomarkers. However, challenges in protein solubility, data analysis, and proteome complexity remain. Recent technological developments include the development of new surfactants, nanoparticles for enriching proteoforms, and strategies for multi-dimensional chromatography separation of proteins.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

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Article Multidisciplinary Sciences

An aged immune system drives senescence and ageing of solid organs

Matthew J. Yousefzadeh et al.

Summary: Researchers found that aged immune system could lead to attrition and senescence of specific immune cell populations, driving systemic ageing.

NATURE (2021)

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Article Biochemistry & Molecular Biology

A proteogenomic portrait of lung squamous cell carcinoma

Shankha Satpathy et al.

Summary: The proteogenomic analysis of LSCC reveals a deeper understanding of its biology and potential therapeutic directions. New therapeutic targets and rationale for further exploration have been identified, along with support for complex regulation of metabolic pathways and immune-related research directions. Furthermore, insights from triangulation with other cancers highlight unique and shared vulnerabilities, guiding future research into LSCC biology and treatment.

CELL (2021)

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Article Geriatrics & Gerontology

Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era

Brandon P. Verdoorn et al.

Summary: Senescent cells (SnCs), which are metabolically active and resistant to apoptosis, increase with age and chronic diseases, making individuals more susceptible to SARS-CoV-2 complications. Senolytic agents, like Fisetin, selectively target and eliminate SnCs, showing promise in delaying or preventing multiple disorders. Clinical trials are underway to investigate the impact of senolytics on decreasing SARS-CoV-2 progression and morbidity in older adults, with logistical challenges considered for conducting trials in long-term care settings.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2021)

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Article Multidisciplinary Sciences

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

Emanuel J. Novais et al.

Summary: Intervertebral disc degeneration is a common issue in the elderly population, leading to chronic back pain and disability. The study shows that long term treatment with senolytic compounds Dasatinib and Quercetin can reduce disc senescence burden and ameliorate age-dependent degeneration in mice.

NATURE COMMUNICATIONS (2021)

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Review Cell Biology

The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets

Martina Rossi et al.

Summary: Senetherapeutics are emerging to suppress the detrimental effects of senescence by targeting either senomorphics or senolytics. The main goal is to suppress the proinflammatory senescence-associated secretory phenotype and promote immune recognition and elimination of senescent cells. One attractive approach is targeting specific molecules or proteins on the surface of senescent cells for senolysis.

CELLS (2021)

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Review Cell Biology

Post-translational Modifications of the Protein Termini

Li Chen et al.

Summary: Post-translational modifications (PTM) involve enzyme-mediated covalent addition of functional groups to proteins during or after synthesis, greatly increasing biological complexity and playing a crucial role in biological regulation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice

Masayoshi Suda et al.

Summary: The study identified GPNMB as a target for senolytic therapy, and immunization against GPNMB improved normal and pathological phenotypes associated with aging, extending the lifespan of aging mice.

NATURE AGING (2021)

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Review Cell Biology

Strategies for targeting senescent cells in human disease

Nathan S. Gasek et al.

Summary: Cellular senescence is a unique cell fate that plays a role in development and wound healing, while also limiting tumor formation. However, the pathologic accumulation of senescent cells is associated with various diseases and age-related morbidities. Research shows that treatments targeting senescent cells through apoptosis induction or inhibition of senescence-related secretory phenotype are beneficial for geriatric decline and chronic diseases.

NATURE AGING (2021)

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Article Food Science & Technology

Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells

Yue Sun et al.

Summary: Fisetin reduces the expression and secretion of inflammatory cytokines in LPS-treated cells by inhibiting the PI3K/AKT/mTOR signaling pathway, and promotes autophagosome-lysosome fusion and degradation.

FOOD & NUTRITION RESEARCH (2021)

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Review Mathematical & Computational Biology

Post-translational modifications in proteins: resources, tools and prediction methods

Shahin Ramazi et al.

Summary: Posttranslational modifications (PTMs) involve modifications to amino acid side chains in proteins after biosynthesis, affecting various aspects of protein functions. Disruptions in PTMs can lead to diseases, emphasizing the need for computational methods to predict PTMs. High-throughput experimental methods for PTM discovery are laborious, prompting the exploration of computational tools and databases to advance research in this area.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2021)

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Article Endocrinology & Metabolism

Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity

Christine Rouault et al.

Summary: The study investigated adipose tissue senescent status and its relationships with metabolic complications in human obesity. Results indicated that senescent cells in subcutaneous adipose tissue are significantly linked to altered glucose metabolism and body fat distribution, and elimination of these cells could alleviate metabolic complications in severely obese individuals.

DIABETOLOGIA (2021)

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Article Geriatrics & Gerontology

Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration

Jae-Byoung Chae et al.

Summary: Eliminating senescent cells may be a potential novel therapeutic approach for all types of AMD, as clearing senescent retinal pigment epithelium cells can ameliorate retinal degeneration, providing new insights into the treatment of AMD.

GEROSCIENCE (2021)

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An NIR-Responsive DNA-Mediated Nanotetrahedron Enhances the Clearance of Senescent Cells

Aihua Qu et al.

ADVANCED MATERIALS (2020)

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Article Cell Biology

Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

Ellen Quarles et al.

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Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy

Norihiko Sasaki et al.

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A proteomic atlas of senescence-associated secretomes for aging biomarker development

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The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications

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EXPERT REVIEW OF PROTEOMICS (2020)

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Editorial Material Biochemistry & Molecular Biology

Detecting Protein-Small Molecule Interactions Using Limited Proteolysis-Mass Spectrometry (LiP-MS)

Monika Pepelnjak et al.

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Salivary proteome signatures in the early and middle stages of human pregnancy with term birth outcome

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Article Biochemical Research Methods

CIRFESS: An Interactive Resource for Querying the Set of Theoretically Detectable Peptides for Cell Surface and Extracellular Enrichment Proteomic Studies

Matthew Waas et al.

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Review Biochemical Research Methods

Acquiring and Analyzing Data Independent Acquisition Proteomics Experiments without Spectrum Libraries

Lindsay K. Pino et al.

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PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208

Sandra Munoz-Galvan et al.

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Article Cell Biology

Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin

Arantzazu Sierra-Ramirez et al.

AGING-US (2020)

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Article Medicine, Research & Experimental

The senescence-associated secretome as an indicator of age and medical risk

Marissa J. Schafer et al.

JCI INSIGHT (2020)

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Review Medicine, General & Internal

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

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Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells

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High throughput quantitative analysis of serum proteins using glycopeptide capture and liquid chromatography mass spectrometry

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Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells

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Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappa B pathway in lipopolysaccharide-stimulated macrophage

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