Sex discrepancies in pathophysiology, presentation, treatment, and outcomes of severe aortic stenosis

Article Cardiac & Cardiovascular Systems

Waiting times of women vs. men undergoing transcatheter aortic valve implantation

Julia Stehli et al.

Summary: This study found that TAVI waiting times are significantly longer in women compared to men and are associated with increased 30-day mortality and heart failure hospitalizations, as well as reduced mobility.

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES (2023)

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Article Cardiac & Cardiovascular Systems

Sex Differences in Outcomes After Transcatheter Aortic Valve Replacement A POPular TAVI Subanalysis

Kees H. van Bergeijk et al.

Summary: This study compared the occurrence of bleeding and ischemic complications after TAVR between women and men under different antiplatelet and oral anticoagulant regimens. The results showed that women had a higher incidence of major or life-threatening bleeding, particularly when taking aspirin.

JACC-CARDIOVASCULAR INTERVENTIONS (2023)

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Article Cardiac & Cardiovascular Systems

Gender Differences in Age-Stratified Early Outcomes in Patients With Transcatheter Aortic Valve Implantation

Chi Zhou et al.

Summary: This study examined the gender and age differences in patients who underwent transcatheter aortic valve implantation (TAVI). The results showed that female patients had similar in-hospital death rates as male patients, and at the 30-day and 6-month follow-up visits, there was no difference in all-cause readmission and major adverse cardiovascular events (MACE) between men and women in most age groups, except for women aged 18 to 59 who were less likely to undergo pacemaker implantation and transfusion. However, women in the 70 to 79 and 80 to 90 age groups had a higher risk of all-cause readmission at the 6-month follow-up.

AMERICAN JOURNAL OF CARDIOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Outcomes of Aortic Valve Replacement for Chronic Aortic Insufficiency: Analysis of the Society of Thoracic Surgeons Database

Christopher T. Ryan et al.

Summary: This study evaluated the outcomes and risk factors for surgical aortic valve replacement (SAVR) for aortic insufficiency (AI) in a national cohort. The results showed that operative mortality and morbidity for isolated SAVR for AI is very low in a national cohort, providing a benchmark for future transcatheter approaches.

ANNALS OF THORACIC SURGERY (2022)

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Article Cardiac & Cardiovascular Systems

2021 ESC/EACTS Guidelines for the management of valvular heart disease Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)

Alec Vahanian et al.

EUROPEAN HEART JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

Sex differences in left ventricular remodelling in patients with severe aortic valve stenosis

Jurrien H. Kuneman et al.

Summary: Sex differences in left ventricular remodeling and outcome after transcatheter aortic valve implantation (TAVI) were examined in patients with severe aortic stenosis (AS). Women demonstrated better outcome after TAVI compared with men, and men were more likely to have concentric remodeling. The interaction between left ventricular remodeling patterns and sex was not associated with survival.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING (2022)

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Article Cardiac & Cardiovascular Systems

Sex Differences in the Impact of Aortic Valve Calcium Score on Mortality After Transcatheter Aortic Valve Replacement

Parth P. Patel et al.

Summary: This study evaluates the impact of sex differences in aortic valve calcium score (AVCS) on long-term mortality following transcatheter aortic valve replacement (TAVR). The results demonstrate a notable sex difference in the association between AVCS and long-term mortality, particularly among women. This study highlights the potential value of AVCS in preprocedural risk stratification, specifically among women undergoing TAVR.

CIRCULATION-CARDIOVASCULAR IMAGING (2022)

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Article Cardiac & Cardiovascular Systems

Sex differences in mortality and 90-day readmission rates after transcatheter aortic valve replacement: a nationwide analysis from the USA

Venkata S. Pajjuru et al.

Summary: The study aims to assess gender differences in in-hospital mortality and 90-day readmission rates among patients who underwent transcatheter aortic valve replacement (TAVR) in the USA. The results showed that both in-hospital mortality and 90-day readmission rates have decreased over time for both genders. However, women still have slightly higher in-hospital mortality and 90-day readmission rates compared to men.

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES (2022)

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Review Cardiac & Cardiovascular Systems

Sex Disparities in Myocardial Infarction: Biology or Bias?

Julia Stehli et al.

Summary: After myocardial infarction (MI), women tend to have worse outcomes compared to men due to various factors such as underestimation of risk in women, delays in diagnosis and treatment, and lower utilization of guideline-directed therapies. These disparities lead to higher mortality, major cardiovascular events, and bleeding in women post-MI. The question of whether these differences are due to biological factors or bias, or a combination of both, remains to be answered through a review of sex disparities in all aspects of acute MI care.

HEART LUNG AND CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

Sex Differences in Radial Access for Percutaneous Coronary Intervention in Acute Coronary Syndrome Are Independent of Body Size

Julia Stehli et al.

Summary: Radial access for PCI in ACS patients is associated with lower bleeding and mortality rates, but it is less frequently used in women. Female sex independently predicts lower radial access use and higher rates of major bleeding and mortality, highlighting disparities in access and outcomes based on gender.

HEART LUNG AND CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

Excess Mortality and Undertreatment of Women With Severe Aortic Stenosis

Christophe Tribouilloy et al.

Summary: Women with severe AS are diagnosed at later ages and have more symptoms than men. Despite prevalent symptoms, AVR is less often performed in women and 5-year excess mortality is noted in women versus men, even after age matching.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Medicine, General & Internal

Prevalence of Bicuspid Aortic Valve and Associated Aortopathy in Newborns in Copenhagen, Denmark

Anne-Sophie Sillesen et al.

Summary: The prevalence of bicuspid aortic valve among newborns in Copenhagen was 0.77%, with aortopathy present in 33% of cases. This suggests that BAV is likely a fetal malformation as indicated by the high rate of aortic disease among affected newborns.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary

Catherine M. Otto et al.

Summary: This executive summary provides updated recommendations for clinicians on diagnosing and managing valvular heart disease. It includes new options for diagnosis and treatment, focusing on diagnostic work-up, surgical and catheter interventions, and medical therapy. Readers are referred to the full guideline for detailed information and rationale behind each recommendation.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Sex disparities in patients with symptomatic severe aortic stenosis

Angela Lowenstern et al.

Summary: This study evaluated the equitable distribution of treatment and outcomes for aortic valve replacement (AVR) among symptomatic severe aortic stenosis (ssAS) patients across sexes. It found that females were less likely to undergo AVR compared to males, but were more likely to choose transcatheter (TAVR) method when treated. There were disparities in female treatment rates for ssAS patients.

AMERICAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Impact of sex on the management and outcome of aortic stenosis patients

David Bienjonetti-Boudreau et al.

Summary: This study aimed to assess the impact of sex on the management and outcome of patients with aortic stenosis (AS). Despite similar baseline hemodynamic AS severity, women were less likely to be referred for aortic valve replacement (AVR) and had higher mortality rates, especially in cases of discordant markers of AS severity.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Sex-Related Differences in the Extent of Myocardial Fibrosis in Patients With Aortic Valve Stenosis

Lionel Tastet et al.

JACC-CARDIOVASCULAR IMAGING (2020)

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Article Medicine, General & Internal

A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement

George D. Dangas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Transvalvular Flow, Sex, and Survival After Valve Replacement Surgery in Patients With Severe Aortic Stenosis

Ezequiel Guzzetti et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Impact of Gender on Transcatheter Aortic Valve Implantation Outcomes

Julia Stehli et al.

AMERICAN JOURNAL OF CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Sex-Specific Determinants of Outcomes After Transcatheter Aortic Valve Replacement

Michele Pighi et al.

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES (2019)

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Article Medicine, General & Internal

Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients

M. J. Mack et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Medicine, General & Internal

Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients

Jeffrey J. Popma et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Age- and Sex-Related Aortic Valve Dysfunction and Aortopathy Difference in Patients with Bicuspid Aortic Valve

Xinshuang Ren et al.

INTERNATIONAL HEART JOURNAL (2019)

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Article Cardiac & Cardiovascular Systems

Sex Differences Persist in Time to Presentation, Revascularization, and Mortality in Myocardial Infarction Treated With Percutaneous Coronary Intervention

Julia Stehli et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

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Letter Cardiac & Cardiovascular Systems

Prolonged Clotting Time Among Patients Undergoing Transcatheter Aortic Valve Replacement

Harold L. Dauerman et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Sex Differences in Transfemoral Transcatheter Aortic Valve Replacement

Wieneke Vlastra et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

Why and How to Measure Aortic Valve Calcification in Patients With Aortic Stenosis

Tania Pawade et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Letter Cardiac & Cardiovascular Systems

Sex-Related Differences in Low-Gradient, Low-Ejection Fraction Aortic Stenosis

Philipp Emanuel Bartko et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Editorial Material Cardiac & Cardiovascular Systems

Long-Term Outcomes With Transcatheter Aortic Valve Replacement in Women Compared With Men Evidence From a Meta-Analysis

Marwan Saad et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2018)

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Article Cardiac & Cardiovascular Systems

Sex-Specific Outcomes of Transcatheter Aortic Valve Replacement With the SAPIEN 3 Valve Insights From the PARTNER II S3 High-Risk and Intermediate-Risk Cohorts

Molly Szerlip et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2018)

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Article Cardiac & Cardiovascular Systems

Sex Dimorphism in the Myocardial Response to Aortic Stenosis

Thomas A. Treibel et al.

JACC-CARDIOVASCULAR IMAGING (2018)

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Article Medicine, General & Internal

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Spencer L. G. James et al.

LANCET (2018)

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Article Cardiac & Cardiovascular Systems

Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement

Adam Castano et al.

EUROPEAN HEART JOURNAL (2017)

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Article Cardiac & Cardiovascular Systems

Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study

Pontus Andell et al.

HEART (2017)

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Article Cardiac & Cardiovascular Systems

Sex Differences in the Utilization and Outcomes of Surgical Aortic Valve Replacement for Severe Aortic Stenosis

Zakeih Chaker et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

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Article Cardiac & Cardiovascular Systems

Quality-of-Life Outcomes After Transcatheter Aortic Valve Replacement in an Unselected Population A Report From the STS/ACC Transcatheter Valve Therapy Registry

Suzanne V. Arnold et al.

JAMA CARDIOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Sex-Based Differences in Outcomes With Transcatheter Aortic Valve Therapy TVT Registry From 2011 to 2014

Jaya Chandrasekhar et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

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Letter Cardiac & Cardiovascular Systems

Sex Differences in the Progression of Aortic Stenosis and Prognostic Implication

Virginia Nguyen et al.

JACC-CARDIOVASCULAR IMAGING (2016)

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Article Cardiac & Cardiovascular Systems

Association of Thoracic Aorta Calcium Score With Exercise Blood Pressure Response and Clinical Outcomes in Elderly Individuals: Differential Impact of Aorta Calcification Compared With Coronary Artery Calcification

In-Jeong Cho et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

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Article Cardiac & Cardiovascular Systems

Revisiting Sex Equality With Transcatheter Aortic Valve Replacement Outcomes A Collaborative, Patient-Level Meta-Analysis of 11,310 Patients

Stephen A. O'Connor et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

Impact of Aortic Valve Calcification, as Measured by MDCT, on Survival in Patients With Aortic Stenosis

Marie-Annick Clavel et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

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Letter Medicine, General & Internal

Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis

Sanjay Kaul

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Cardiac & Cardiovascular Systems

Aortic Stenosis in the Elderly Disease Prevalence and Number of Candidates for Transcatheter Aortic Valve Replacement: A Meta-Analysis and Modeling Study

Ruben L. J. Osnabrugge et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

EuroSCORE II†

Samer A. M. Nashef et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2012)

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Article Cardiac & Cardiovascular Systems

Age and Sex Differences in Duration of Prehospital Delay in Patients With Acute Myocardial Infarction A Systematic Review

Hoa L. Nguyen et al.

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES (2010)

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Article Cardiac & Cardiovascular Systems

The Society of Thoracic Surgeons 2008 Cardiac Surgery Risk Models: Part 2-Isolated Valve Surgery

Sean M. O'Brien et al.

ANNALS OF THORACIC SURGERY (2009)

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Editorial Material Medicine, General & Internal

Calcific aortic stenosis - Time to look more closely at the valve

Catherine M. Otto

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Sex discrepancies in pathophysiology, presentation, treatment, and outcomes of severe aortic stenosis

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