Safety and efficacy of His-Purkinje system pacing in the treatment of patients with atrial fibrillation and heart failure: a systematic review and meta-analysis

Article Cardiac & Cardiovascular Systems

Feasibility and safety of both His bundle pacing and left bundle branch area pacing in atrial fibrillation patients: intermediate term follow-up

Yang Ye et al.

Summary: This study evaluated the feasibility and safety of His bundle pacing (HBP) and left bundle branch area pacing (LBBAP) in atrial fibrillation (AF) patients and found that both methods effectively improved heart failure symptoms.

JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY (2023)

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Review Cardiac & Cardiovascular Systems

His-Purkinje conduction system pacing for pacing-induced cardiomyopathy: a systematic literature review and meta-analysis

Rujie Zheng et al.

Summary: Our meta-analysis demonstrates that upgrading to HPCSP is feasible and efficient in patients with PICM, as it significantly improves electrical synchrony and cardiac function.

JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Comparison of His-Purkinje Conduction System Pacing with Atrial-Ventricular Node Ablation and Pharmacotherapy in HFpEF Patients with Recurrent Persistent Atrial Fibrillation (HPP-AF study)

J. F. Zhang et al.

Summary: This study aims to evaluate a new treatment strategy for patients with persistent atrial fibrillation who have experienced recurrent episodes even after multiple attempts of radio-frequency catheter ablation. The proposed treatment involves atrioventricular node ablation and His-Purkinje conduction system pacing (HPCSP) to control ventricular rate and maintain regular heart rhythm.

CARDIOVASCULAR DRUGS AND THERAPY (2023)

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Article Cardiac & Cardiovascular Systems

Biventricular versus His bundle pacing after atrioventricular node ablation in heart failure patients with narrow QRS

David Zizek et al.

Summary: This study compared the short-term outcomes of HBP and BiV pacing in symptomatic atrial fibrillation patients and found that HBP was superior in post-implant QRS duration, LV volumes, and LVEF compared to BiV pacing. However, both groups showed similar improvement in NYHA class.

ACTA CARDIOLOGICA (2022)

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Article Cardiac & Cardiovascular Systems

Atrioventricular junction ablation in patients with conduction system pacing leads: A comparison of His-bundle vs left bundle branch area pacing leads

Ajay Pillai et al.

Summary: AVJA with left bundle branch area pacing (LBBAP) leads shows a higher success rate and fewer lead-related complications.

HEART RHYTHM (2022)

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Article Cardiac & Cardiovascular Systems

Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block

Margarida Pujol-Lopez et al.

Summary: This study compared the echocardiographic response and clinical improvement between His-Purkinje conduction system pacing (HPCSP) and biventricular cardiac resynchronization therapy (BiVCRT) in patients with left ventricular dysfunction. The results showed that HPCSP improved left ventricular ejection fraction (LVEF) and induced a similar response to BiVCRT in patients with LVEF ≤ 45% and atrioventricular block. Additionally, HPCSP significantly improved mitral regurgitation and NYHA functional class.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Short QRS Duration After His-Purkinje Conduction System Pacing Predicts Left Ventricular Complete Reverse Remodeling in Patients With True Left Bundle Branch Block and Heart Failure

Xu-Min Guan et al.

Summary: This study found that complete reverse remodeling of the left ventricle could be achieved in nearly half of the patients with HFrEF and true LBBB after HPCSP, and a shorter QRS duration after HPCSP was a strong predictor.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

His-bundle pacing vs biventricular pacing following atrioventricular nodal ablation in patients with atrial fibrillation and reduced ejection fraction: A multicenter, randomized, crossover study-The ALTERNATIVE-AF trial

Weijian Huang et al.

Summary: This study compared the effects of His-bundle pacing (HBP) and biventricular pacing (BVP) in patients who underwent atrioventricular nodal ablation (AVNA). The results showed that HBP led to a significant improvement in left ventricular ejection fraction (LVEF) compared to BVP. Both pacing modalities had similar effects on improving left ventricular end-diastolic diameter, functional class, and B-type natriuretic peptide level.

HEART RHYTHM (2022)

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Article Cardiac & Cardiovascular Systems

Impact of atrioventricular junction ablation and CRT-D on long-term mortality in patients with left ventricular dysfunction, permanent, refractory atrial fibrillation, and narrow QRS: Results of a propensity-matched analysis

Pietro Palmisano et al.

Summary: The long-term prognosis of patients with HFrEF, narrow QRS, and PEAF who underwent AVJA plus CRT was similar to that of a population of patients in SR with similar characteristics.

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Left Bundle Branch Pacing Postatrioventricular Junction Ablation for Atrial Fibrillation: Propensity Score Matching With His Bundle Pacing

Mengxing Cai et al.

Summary: This study found that LBBP is feasible, safe, and effective in pacemaker-dependent patients with atrial fibrillation and HF after AVJ ablation, and it has similar clinical benefits, a higher implant success rate, better pacing parameters, and fewer complications compared with HBP.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Randomized Trial of Left Bundle Branch vs Biventricular Pacing for Cardiac Resynchronization Therapy

Yao Wang et al.

Summary: Left bundle branch pacing (LBBP) shows greater improvement in left ventricular ejection fraction (LVEF) compared to biventricular pacing (BiVP) in heart failure patients with nonischemic cardiomyopathy and left bundle branch block (LBBB).

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Conduction system pacing versus conventional pacing in patients undergoing atrioventricular node ablation: Nonrandomized, on-treatment comparison

Pugazhendhi Vijayaraman et al.

Summary: This study compares the clinical outcomes of conventional pacing (CP) and conduction system pacing (CSP) in patients undergoing atrioventricular node ablation (AVNA). The results show that CSP can significantly reduce the combined endpoint of death or heart failure hospitalization.

HEART RHYTHM O2 (2022)

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Article Cardiac & Cardiovascular Systems

Biventricular versus Conduction System Pacing after Atrioventricular Node Ablation in Heart Failure Patients with Atrial Fibrillation

Maja Ivanovski et al.

Summary: Conduction system pacing (CSP) modalities, including His-bundle pacing (HBP) and left bundle branch pacing (LBBP), showed superior symptomatic and echocardiographic improvement compared to biventricular (BiV) pacing in heart failure patients.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2022)

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Article Cardiac & Cardiovascular Systems

Comparison of cardiac function between left bundle branch pacing and right ventricular outflow tract septal pacing in the short-term: A registered controlled clinical trial

Qian Liu et al.

Summary: The study demonstrates that compared to conventional RVOP, LBBP can enhance cardiac function, improve BNP levels, and show advantages in left atrial function in the short term.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Impact of QRS morphology on response to conduction system pacing after atrioventricular junction ablation

Shengjie Wu et al.

Summary: This study aimed to assess the benefit of left bundle branch block (LBBB) correction using His-Purkinje conduction system pacing (HPCSP) in atrial fibrillation patients post-AVJ ablation. Results showed that LBBB patients had greater improvement in LVEF and NYHA class function compared to those with narrow QRS duration.

ESC HEART FAILURE (2021)

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Article Cardiac & Cardiovascular Systems

His-purkinje system pacing upgrade improve the heart performances in patients suffering from pacing-induced cardiomyopathy with or without permanent atrial fibrillation

Yi-heng Yang et al.

Summary: HPSP upgrades improved heart performance and reversed left ventricular remodeling in patients with PICM, whether they have AF or not. The treatment showed promising results in improving clinical outcomes.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Effectiveness and safety of AV node ablation after His bundle pacing in patients with uncontrolled atrial arrhythmias

Pablo Morina-Vazquez et al.

Summary: In patients with uncontrolled atrial arrhythmias who underwent AV node ablation after p-HBP, NYHA class improved and LVEF increased in those with reduced baseline LVEF.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial

Michele Brignole et al.

Summary: Ablation + CRT treatment is superior in reducing all-cause mortality in severely symptomatic permanent AF patients. Furthermore, this treatment also significantly lowers the combined endpoint of all-cause mortality or HF hospitalization.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Comparison of synchronization between left bundle branch and his bundle pacing in atrial fibrillation patients: An intra-patient-controlled study

Xia Sheng et al.

Summary: This study evaluated cardiac electrical and mechanical synchrony comparing LBBP and HBP in patients with permanent AF, showing similar LV function between the two pacing modes but a modest delay in RV activation with LBBP, which requires further investigation.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Brady-arrhythmias in patients with atrial fibrillation and heart failure of reduced ejection fraction: is his-bundle pacing superior to biventricular pacing?

Pei-pei Ma et al.

Summary: His-bundle pacing (HBP) was found to be safer and more effective than traditional biventricular pacing (BVP) in improving cardiac function and remodeling in patients with bradyarrhythmias, permanent AF, and HFrEF.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

A Randomized Trial of His Pacing Versus Biventricular Pacing in Symptomatic HF Patients With Left Bundle Branch Block (His-Alternative)

Michael Vinther et al.

Summary: This study compared His-CRT and BiV-CRT in patients with symptomatic heart failure and LBBB, finding similar clinical and physical improvements in both groups at the 6-month follow-up, with His-CRT requiring higher pacing thresholds.

JACC-CLINICAL ELECTROPHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems