d-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis

Review Biochemistry & Molecular Biology

Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal

Hironari Nishizawa et al.

Summary: Ferroptosis is a form of cell death triggered by intracellular peroxidation of cell membrane phospholipids. It is regulated by transcription factors NRF2 and BACH1, which control various pathways and processes involved in ferroptosis.

FEBS JOURNAL (2023)

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Article Biotechnology & Applied Microbiology

PDGF-BB-derived supramolecular hydrogel for promoting skin wound healing

Ke Jian et al.

Summary: Chronic wounds present a major challenge to the healthcare system. This study designed a PDGF-mimicking peptide that can promote angiogenesis and collagen deposition, showing promising therapeutic effects for wound healing.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Cell Biology

Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers

Jiawei Feng et al.

Summary: This review explores the pathological mechanisms of delayed wound healing in diabetic ulcers, revealing the potential association between ferroptosis and diabetic ulcer healing delay, and proposes new treatment strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Cell Biology

Interplay of Nrf2 and BACH1 in inducing ferroportin expression and enhancing resistance of human macrophages towards ferroptosis

Dmitry Namgaladze et al.

Summary: Compared to cancer cells, macrophages have a resistance to iron-dependent cell death known as ferroptosis. This study reveals that the induction of ferroportin, an iron transporter, is a protective mechanism in macrophages against ferroptosis, and its expression is regulated by the transcription factors Nrf2 and BACH1.

CELL DEATH DISCOVERY (2022)

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Article Cell Biology

Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing

Sebastian Willenborg et al.

Summary: The study found that changes in cellular metabolism play a critical role in regulating macrophage functions during wound healing.

CELL METABOLISM (2021)

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Article Biochemistry & Molecular Biology

Nrf2-induced miR-23a-27a-24-2 cluster modulates damage repair of intestinal mucosa by targeting the Bach1/HO-1 axis in inflammatory bowel diseases

Dun Su et al.

Summary: This study revealed that the Nrf2/miR-23a-27a-24-2/Bach1/HO-1 regulatory axis promotes the damage repair of intestinal mucosa during the development of inflammatory bowel diseases.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Ophthalmology

Haem relieves hyperoxia-mediated inhibition of HMEC-1 cell proliferation, migration and angiogenesis by inhibiting BACH1 expression

Lan Jian et al.

Summary: This study found that haem can relieve the inhibition of VEGF activity in HMEC-1 cells induced by hyperoxia by inhibiting BACH1, potentially serving as a medication for overcoming stunted retinal angiogenesis induced by relative hyperoxia during phase I ROP.

BMC OPHTHALMOLOGY (2021)

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Review Cell Biology

A Novel Therapeutic Target, BACH1, Regulates Cancer Metabolism

Joselyn Padilla et al.

Summary: BACH1 is a transcription factor highly expressed in tumors, promoting invasion and metastasis of cancer cells and presenting a poor outcome for cancer patients. Recent studies have identified novel functional roles of BACH1 in the regulation of metabolic pathways in cancer cells.

CELLS (2021)

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Article Biochemistry & Molecular Biology

Ca2+ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells

Michela Raimondi et al.

Summary: The study demonstrates that delta-tocotrienol induces paraptotic cell death in human melanoma cells, causing endoplasmic reticulum dilation and mitochondrial swelling. These alterations lead to impaired mitochondrial function, ROS production, and calcium overload.

APOPTOSIS (2021)

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Article Biochemistry & Molecular Biology

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer?s diseases

Min Woo Park et al.

Summary: The study found elevated levels of NOX4 protein in impaired astrocytes of AD patients and mouse AD models, leading to oxidative stress and ferroptosis. Overexpression of NOX4 resulted in impaired mitochondrial metabolism and oxidative stress, increasing ferroptosis in astrocytes.

REDOX BIOLOGY (2021)

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Article Endocrinology & Metabolism

Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound

Shuangwen Li et al.

Summary: Ferroptosis plays a crucial role in diabetic wound healing, with inhibition of ferroptosis reducing inflammation and promoting wound healing. Restraint of ferroptosis leads to restoration of the PI3K/AKT signal pathway in diabetic wounds, ultimately mitigating ferroptosis and enhancing wound healing.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

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Article Biotechnology & Applied Microbiology

Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways

Jie Wang et al.

Summary: Research indicates that hypoxic adipose stem cells exosomes (HypADSCs-exo) can promote diabetic wound healing by regulating miRNAs and the PI3K/AKT signaling pathway, inhibiting inflammatory response.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing

Jessica Hoff et al.

Summary: Inflammation is crucial for tissue remodeling during wound healing, and control of the inflammatory response is important for proper wound healing. Topical application of natural anti-inflammatory products can improve wound healing, especially in chronic conditions. Long-chain metabolites of vitamin E have bioactive properties that can mediate cellular effects through oxidative stress signaling and anti-inflammatory pathways, with the potential to enhance wound healing.

NANOMATERIALS (2021)

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Review Cell Biology

Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis

Guya D. Marconi et al.

Summary: The epithelial-mesenchymal transition (EMT) is a crucial event in cell development, playing key roles in wound healing and organ fibrosis. EMT is classified into three types: type-1 EMT, type-2 EMT, and type-3 EMT, each with specific functions in embryogenesis, wound healing, and cancer progression respectively.

CELLS (2021)

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Review Cell Biology

The Role of MSC in Wound Healing, Scarring and Regeneration

Raquel Guillamat-Prats

Summary: This review discusses the effects of MSCs and their derived products in each step of the wound repair process, as well as the pre-clinical and clinical use of MSCs in skin wound healing in diabetic associated wounds and in pathophysiological fibrosis.

CELLS (2021)

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Article Multidisciplinary Sciences

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Tianzhi Wu et al.

Summary: The updated version of clusterProfiler 4.0 is a powerful tool for functional enrichment analysis in a wide range of organisms, offering tidy interfaces for data operation and visualization, as well as new features like gene set enrichment analysis and comparison of results from multiple gene lists.

INNOVATION (2021)

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Article Biochemistry & Molecular Biology

δ-Tocotrienol induces apoptosis and inhibits proliferation of nasopharyngeal carcinoma cells

Junjun Shen et al.

Summary: delta-Tocotrienol demonstrates chemopreventive effects on nasopharyngeal carcinoma cells by inducing apoptosis and cell cycle arrest. Gene expression analysis reveals its impact on CNE1 cells' gene regulation.

FOOD & FUNCTION (2021)

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Article Cell & Tissue Engineering

Effect of PDGF-B Gene-Activated Acellular Matrix and Mesenchymal Stem Cell Transplantation on Full Thickness Skin Burn Wound in Rat Model

Tamilmahan Paramasivam et al.

Summary: This study demonstrated that implanting gene-activated acellular matrix encoding for PDGF-B protein and transfected stem cells can enhance healing of full thickness burn wounds in rat models by promoting angiogenesis and tissue regeneration. The results suggest that PDGF gene activation in the matrix stimulates neovascularization and wound healing through the release of growth factors, ultimately facilitating regenerative activities.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

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Article Nutrition & Dietetics