4.6 Review

Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Anatomy & Morphology

Biomaterial Strategies to Bolster Neural Stem Cell-Mediated Repair of the Central Nervous System

Giancarlo Tejeda et al.

Summary: Stem cell therapies have the potential to repair and regenerate tissue in the central nervous system. However, low transplant survival remains a major obstacle. The use of biomaterials can significantly improve the survival of transplanted stem cells by providing protection and controlling the cytotoxic injury environment.

CELLS TISSUES ORGANS (2023)

Article Clinical Neurology

Cortical neuronal hyperexcitability and synaptic changes in SGCE mutation-positive myoclonus dystonia

Alessandra Sperandeo et al.

Summary: The study reveals that SGCE mutations lead to hyperexcitability in cortical stem cells, both at the network and single cell level. This is accompanied by longer and more complex neurite morphology, as well as disruption of synaptic adhesion molecules. The findings shed light on the pathogenesis of myoclonus dystonia and provide potential therapeutic targets.
Article Cell Biology

Reducing host aldose reductase activity promotes neuronal differentiation of transplanted neural stem cells at spinal cord injury sites and facilitates locomotion recovery

Kun Zhang et al.

Summary: Inhibition of host AR activity promotes the polarization of M2 macrophages and enhances the survival and neuronal differentiation of transplanted NSCs, showing potential as a treatment for spinal cord injury.

NEURAL REGENERATION RESEARCH (2022)

Article Cell & Tissue Engineering

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants

Patrick Aldrin-Kirk et al.

Summary: Transplanting hESC-derived DA neurons in Parkinson's disease using a novel virus vector to observe their projections, revealing potential integration with host circuitry based on differential afferent inputs.

STEM CELL REPORTS (2022)

Review Chemistry, Medicinal

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Qing-zhang Tuo et al.

Summary: Ischemic stroke caused by arterial occlusion is a common type of stroke that involves multiple cell death pathways such as apoptosis, necroptosis, and autophagy. Understanding these pathways may reveal new neuroprotective interventions for ischemic stroke.

MEDICINAL RESEARCH REVIEWS (2022)

Article Medicine, General & Internal

Brain Extract of Subacute Traumatic Brain Injury Promotes the Neuronal Differentiation of Human Neural Stem Cells via Autophagy

Zhenghui He et al.

Summary: This study found that around 7 days after TBI in mice, the subacute phase could encourage more neuronal differentiation after transplantation. The autophagy flux played a critical role in regulating neuronal differentiation and could be a potential target to improve the efficacy of transplantation in the early phase.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Neurosciences

Identifying the optimal developmental age of human pluripotent stem cell-derived midbrain dopaminergic progenitors for transplantation in a rodent model of Parkinson's disease

I. R. de Luzy et al.

Summary: The age of donor cells has a significant impact on the outcomes of transplantation of dopaminergic progenitor cells. Transplanting ventral midbrain progenitor cells from varying days of differentiation into a rodent PD model, it was found that younger donor cells can better restore motor deficits with higher proportions of dopaminergic neurons and better neural connectivity.

EXPERIMENTAL NEUROLOGY (2022)

Review Neurosciences

Development of myelinating glia: An overview

Carlo D. Cristob et al.

Summary: Myelin is crucial for the function of the nervous system, and it is formed by OLs in the central nervous system and SCs in the peripheral nervous system. OLs are derived from neural stem cells and follow an intrinsic developmental program, while SCs originate from the neural crest and rely more on extrinsic signals. The differentiation mechanisms of OLs and SCs are distinct due to their unique lineages and environments. Both OLs and SCs respond to neuronal activity and regulate nervous system output.
Article Cell & Tissue Engineering

Characterization of Human-Induced Neural Stem Cells and Derivatives following Transplantation into the Central Nervous System of a Nonhuman Primate and Rats

Mengjia Li et al.

Summary: The study successfully reprogrammed human peripheral blood mononuclear cells into induced neural stem cells and tracked the transplantation using GFP gene insertion. The induced neural stem cells and their derivatives survived and differentiated into mature neurons after transplantation.

STEM CELLS INTERNATIONAL (2022)

Article Multidisciplinary Sciences

Fast generation of forebrain oligodendrocyte spheroids from human embryonic stem cells by transcription factors

Ling Ma et al.

Summary: This study presents a strategy to rapidly and efficiently generate forebrain oligodendrocyte spheroids by overexpressing SOX10 and OLIG2 in human embryonic stem cells. The generated spheroids contain mature oligodendrocytes, pre-oligodendrocytes, and neurons, providing a valuable system for studying demyelinating diseases and testing therapeutic treatments. Transplantation of these spheroids into mouse brains resulted in the development of mature oligodendrocytes that myelinated axons, demonstrating the potential for this method in developing new therapeutics.

ISCIENCE (2022)

Article Medicine, Research & Experimental

Shh and Olig2 sequentially regulate oligodendrocyte differentiation from hiPSCs for the treatment of ischemic stroke

Jian Xu et al.

Summary: By using a chemically defined protocol, we were able to generate a substantial number of transplantable and functional OLs from hiPSCs, which holds promise for cell-based therapy in ischemic stroke.

THERANOSTICS (2022)

Article Biochemical Research Methods

Protocol Generation of highly pure motor neurons from human induced pluripotent stem cells

Masuma Akter et al.

Summary: This study presents a protocol for generating neural progenitor cells and functional motor neurons from human pluripotent stem cells. The optimized induction condition allows for high yield and purity, enabling the identification of dysregulated factors in diseased neurons.

STAR PROTOCOLS (2022)

Article Cell & Tissue Engineering

Tracking Neural Stem Cells in vivo: Achievements and Limitations

Chun-Ran Xue et al.

Summary: Neural stem cell (NSC) therapies are a rapidly developing treatment option for neurological diseases. The tracking and monitoring of NSCs is a crucial issue, which can be addressed through multimodal imaging and different labeling methods. However, safety concerns regarding cell viability still need to be addressed.

STEM CELL REVIEWS AND REPORTS (2022)

Review Biochemistry & Molecular Biology

Stem cell therapy for Alzheimer's disease: An overview of experimental models and reality

Chuan Qin et al.

Summary: Alzheimer's disease is a neurodegenerative disorder that can be improved by stem cell transplantation, which has the potential to ameliorate cognitive deficits. Stem cell transplantation has inherent advantages in improving cognitive impairment and memory dysfunction, but certain limitations need to be overcome.

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2022)

Article Cell Biology

Induced neural stem cells-derived spinal cord progenitor cells as stable stage for rapid and efficient generation of human oligodendrocytes and motor neurons

Xihe Tang et al.

Summary: This study successfully generated Olig2(+) spinal cord progenitor cells from human induced neural stem cells, demonstrating their ability to differentiate into oligodendrocytes and motor neurons. The results show that these Olig2(+) progenitor cells can rapidly mature into specific neuronal and glial cell types, providing a useful model for exploring the development of the spinal cord and regenerative medicine.

CONNECTIVE TISSUE RESEARCH (2021)

Article Cell & Tissue Engineering

Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function

Man Xiong et al.

Summary: The study demonstrates that human embryonic stem cell-derived neurons have the ability to repair specific circuits and restore functionality in the adult brain, leading to improvements in motor function.

CELL STEM CELL (2021)

Article Pharmacology & Pharmacy

Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases

Xinnan Li et al.

Summary: Neurodegenerative diseases are common and incurable disorders in the elderly, with impaired mitophagy playing a significant role in their progression. Therapeutic strategies targeting mitophagy show promise in recent studies.

PHARMACOLOGICAL RESEARCH (2021)

Review Biochemistry & Molecular Biology

Towards Advanced iPSC-based Drug Development for Neurodegenerative Disease

Svetlana Pasteuning-Vuhman et al.

Summary: Neurodegenerative diseases (NDDs) are a group of heterogeneous diseases characterized by the progressive loss of neurons leading to various defects. Current treatments focus on alleviating symptoms and halting disease progression, but drug development for NDDs faces challenges such as phenotypic heterogeneity and lack of robust biomarkers. Innovative approaches like induced pluripotent stem cell (iPSC) methods and brain organoids are being explored to improve drug development for NDDs.

TRENDS IN MOLECULAR MEDICINE (2021)

Review Cell Biology

The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease

Houman Kahroba et al.

Summary: Neurodegenerative diseases are characterized by the progressive loss of neurons in the nervous system, with oxidative stress, inflammation, and synaptic dysfunction being key hallmarks. Neural stem cells play a crucial role in adult neurogenesis in certain regions of the brain, and the transcription factor Nrf2 can influence NSC function and fate determination by maintaining redox homeostasis and reducing reactive oxygen species levels. Promising strategies for treating NDs include protecting neural cells from oxidative damage and supporting neurogenesis.

AGEING RESEARCH REVIEWS (2021)

Article Engineering, Biomedical

Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury

Yaming Yang et al.

Summary: The combination treatment of small molecules and collagen hydrogel can induce in situ endogenous NSCs to form neurons and restore damaged functions, providing a potential therapeutic strategy for SCI.

BIOMATERIALS (2021)

Article Multidisciplinary Sciences

Genetic dissection of the glutamatergic neuron system in cerebral cortex

Katherine S. Matho et al.

Summary: The study established genetic strategies and tools to dissect and fate-map subpopulations of pyramidal neurons based on their developmental and molecular programs. Through combinatorial strategies, subsets of pyramidal neurons defined by developmental origin, marker expression, anatomical location, and projection targets can be targeted for viral access. These strategies provide an experimental framework for understanding the hierarchical organization and developmental trajectory of subpopulations of pyramidal neurons.

NATURE (2021)

Article Immunology

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke

Ligen Shi et al.

Summary: The study found that after experimental stroke, Treg cells infiltrate the brain in mice and promote white matter repair and functional recovery. Treg cells enhance microglial reparative activity, promoting oligodendrogenesis and white matter repair. Increasing Treg cell numbers can improve white matter integrity and rescue neurological functions in the long term.

IMMUNITY (2021)

Article Cell Biology

A Step-by-Step Refined Strategy for Highly Efficient Generation of Neural Progenitors and Motor Neurons from Human Pluripotent Stem Cells

Jie Ren et al.

Summary: Efforts have been made to establish efficient methods for neural differentiation from human pluripotent stem cells, resulting in rapid generation of neural progenitor cells and motor neurons. Differentiation protocols involving retinoic acid induction and dual-SMAD pathway inhibition were compared for their effectiveness in generating specific neural subtypes.
Article Multidisciplinary Sciences

Deep learning-based predictive identification of neural stem cell differentiation

Yanjing Zhu et al.

Summary: The differentiation of neural stem cells into neurons is crucial for potential cell-based therapeutic strategies for CNS diseases. Using deep learning, researchers have developed a reliable model for predicting NSCs fate, demonstrating high precision in identifying differentiated cell types early in culture and applicability across various inducers.

NATURE COMMUNICATIONS (2021)

Review Neurosciences

Dopamine Cell Therapy: From Cell Replacement to Circuitry Repair

Anders Bjorklund et al.

Summary: Cell therapy for Parkinson's disease aims to replace degenerated midbrain dopamine neurons and restore neurotransmission, but current approaches may be limited in their effectiveness, requiring a more comprehensive strategy to improve outcomes.

JOURNAL OF PARKINSONS DISEASE (2021)

Article Materials Science, Biomaterials

Biodegradable aniline-derived electroconductive film for the regulation of neural stem cell fate

Keui-Yu Chao et al.

Summary: A bioactive conductive film composed of oxidative polymerized CCAP and ring-opening polymerized 4a-PLA with the addition of chondroitin sulfate was designed to control NSC fate and enhance neural tissue regeneration. The material showed structural integrity, cell adhesion properties, and biodegradability, making it a promising platform for neural stem cell fate determination and applications in neural regeneration and neuroprosthetics.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Review Biochemistry & Molecular Biology

Neural Stem Cell Transplantation for Neurodegenerative Diseases

Roberta De Gioia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior

Sara Palma-Tortosa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Cardiac & Cardiovascular Systems

Hyperacute Management of Ischemic Strokes

Pratit Patel et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Review Clinical Neurology

Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy

Aishika Datta et al.

TRANSLATIONAL STROKE RESEARCH (2020)

Article Medicine, General & Internal

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease

Jeffrey S. Schweitzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

Acquisition of the Midbrain Dopaminergic Neuronal Identity

Simone Mesman et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Chemistry, Multidisciplinary

Fluorescent Diagnostic Probes in Neurodegenerative Diseases

Jin Zhou et al.

ADVANCED MATERIALS (2020)

Article Biochemical Research Methods

Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells

Juan Antonio Garcia-Leon et al.

NATURE PROTOCOLS (2020)

Editorial Material Clinical Neurology

Beyond recanalization - a call for action in acute stroke

Guido Stoll et al.

NATURE REVIEWS NEUROLOGY (2020)

Review Neurosciences

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Hyuk Sung Kwon et al.

TRANSLATIONAL NEURODEGENERATION (2020)

Article Biochemical Research Methods

An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions

Carlos W. Gantner et al.

STAR PROTOCOLS (2020)

Review Neurosciences

Neural stem cell therapies and hypoxic-ischemic brain injury

Lei Huang et al.

PROGRESS IN NEUROBIOLOGY (2019)

Article Neurosciences

Engineering biomaterials to control the neural differentiation of stem cells

Joshua A. Zimmermann et al.

BRAIN RESEARCH BULLETIN (2019)

Review Clinical Neurology

Post-stroke inflammation-target or tool for therapy?

Kate Lykke Lambertsen et al.

ACTA NEUROPATHOLOGICA (2019)

Review Pharmacology & Pharmacy

Harnessing stem cells and biomaterials to promote neural repair

K. F. Bruggeman et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Cell Biology

Neural stem cell niche heterogeneity

Julia P. Andreotti et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

Review Neurosciences

The Underlying Role of Oxidative Stress in Neurodegeneration: A Mechanistic Review

Habib Yaribeygi et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2018)

Article Biochemistry & Molecular Biology

MicroRNA-29a regulates neural stem cell neuronal differentiation by targeting PTEN

Zhongju Shi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Review Neurosciences

Neural stem cell heterogeneity in the mammalian forebrain

Kelsey V. Adams et al.

PROGRESS IN NEUROBIOLOGY (2018)

Article Cell & Tissue Engineering

Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells

Aslam Abbasi Akhtar et al.

STEM CELL REPORTS (2018)

Review Biotechnology & Applied Microbiology

Neural stem cell differentiation into mature neurons: Mechanisms of regulation and biotechnological applications

Mariana S. Vieira et al.

BIOTECHNOLOGY ADVANCES (2018)

Review Multidisciplinary Sciences

New approaches for brain repair-from rescue to reprogramming

Roger A. Barkers et al.

NATURE (2018)

Article Cell & Tissue Engineering

A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs

Menghua Wu et al.

STEM CELL REPORTS (2018)

Article Cell Biology

Melatonin Increases Oligodendrocyte Differentiation in Cultured Neural Stem Cells

Majid Ghareghani et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2017)

Article Multidisciplinary Sciences

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model

Tetsuhiro Kikuchi et al.

NATURE (2017)

Article Multidisciplinary Sciences

Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors

Marc Ehrlich et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Cell & Tissue Engineering

Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives

Go Itakura et al.

STEM CELL REPORTS (2017)

Article Cell Biology

Oligodendrocyte Development and Plasticity

Dwight E. Bergles et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Review Cell & Tissue Engineering

Neural Subtype Specification from Human Pluripotent Stem Cells

Yunlong Tao et al.

CELL STEM CELL (2016)

Article Cell & Tissue Engineering

Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease

Yuejun Chen et al.

CELL STEM CELL (2016)

Review Neurosciences

Modeling ALS with motor neurons derived from human induced pluripotent stem cells

Samuel Sances et al.

NATURE NEUROSCIENCE (2016)

Article Neurosciences

White matter injury in ischemic stroke

Yuan Wang et al.

PROGRESS IN NEUROBIOLOGY (2016)

Article Multidisciplinary Sciences

Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1

Bumpei Samata et al.

NATURE COMMUNICATIONS (2016)

Review Cell & Tissue Engineering

Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells

Rickie Patani

STEM CELLS INTERNATIONAL (2016)

Article Medicine, Research & Experimental

Elimination of proliferating cells from CNS grafts using a Ki67 promoter-driven thymidine kinase

Vannary Tieng et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2016)

Review Neurosciences

Classic and novel stem cell niches in brain homeostasis and repair

Ruihe Lin et al.

BRAIN RESEARCH (2015)

Article Developmental Biology

How to make an oligodendrocyte

Steven A. Goldman et al.

DEVELOPMENT (2015)

Article Biochemical Research Methods

High purity of human oligodendrocyte progenitor cells obtained from neural stem cells: Suitable for clinical application

Caiying Wang et al.

JOURNAL OF NEUROSCIENCE METHODS (2015)

Article Biotechnology & Applied Microbiology

Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson's disease model

Julius A. Steinbeck et al.

NATURE BIOTECHNOLOGY (2015)

Article Biochemical Research Methods

Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells

Panagiotis Douvaras et al.

NATURE PROTOCOLS (2015)

Article Cell Biology

Neurogenesis in the Adult Hippocampus

Gerd Kempermann et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Multidisciplinary Sciences

Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells

Zhong-Wei Du et al.

NATURE COMMUNICATIONS (2015)

Article Cell & Tissue Engineering

Characterisation of neurons derived from a cortical human neural stem cell line CTX0E16

Greg W. Anderson et al.

STEM CELL RESEARCH & THERAPY (2015)

Article Cell & Tissue Engineering

In Vitro Differentiation of Human Neural Progenitor Cells Into Striatal GABAergic Neurons

Lin Lin et al.

STEM CELLS TRANSLATIONAL MEDICINE (2015)

Review Geriatrics & Gerontology

Cell Therapy for Parkinson's Disease: New Hope from Reprogramming Technologies

Zhiguo Chen

AGING AND DISEASE (2015)

Article Cell & Tissue Engineering

Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1

Evangelos Kiskinis et al.

CELL STEM CELL (2014)

Article Developmental Biology

How to make spinal motor neurons

Brandi N. Davis-Dusenbery et al.

DEVELOPMENT (2014)

Article Multidisciplinary Sciences

STAT3 Modulation to Enhance Motor Neuron Differentiation in Human Neural Stem Cells

Rajalaxmi Natarajan et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Comparison and Optimization of hiPSC Forebrain Cortical Differentiation Protocols

Christina R. Muratore et al.

PLOS ONE (2014)

Review Neurosciences

Motor neurons and the generation of spinal motor neuron diversity

Nicolas Stifani

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Medicine, Research & Experimental

Pluripotent Stem Cell-Derived Somatic Stem Cells as Tool to Study the Role of MicroRNAs in Early Human Neural Development

B. Roese- Koerner et al.

CURRENT MOLECULAR MEDICINE (2013)

Article Developmental Biology

Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of Parkinsonian rats

Xuefeng Tan et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2013)

Article Developmental Biology

Epigenetic regulation of neural stem cell fate during corticogenesis

Chai MuhChyi et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2013)

Review Biochemistry & Molecular Biology

Adult neural stem cells: and endogenous tool to repair brain injury?

Gian Carlo Bellenchi et al.

JOURNAL OF NEUROCHEMISTRY (2013)

Article Neurosciences

Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells

Mackenzie W. Amoroso et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

MicroRNA-Based Promotion of Human Neuronal Differentiation and Subtype Specification

Laura Stappert et al.

PLOS ONE (2013)

Review Neurosciences

The Role of Organizers in Patterning the Nervous System

Clemens Kiecker et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 35 (2012)

Article Cell & Tissue Engineering

Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

Marc Thier et al.

CELL STEM CELL (2012)

Review Biochemistry & Molecular Biology

Transcriptional control of glutamatergic differentiation during adult neurogenesis

Rebecca D. Hodge et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Biochemistry & Molecular Biology

Directing Neuronal Differentiation of Primary Neural Progenitor Cells by Gene Knockdown Approach

Wei Ching Low et al.

DNA AND CELL BIOLOGY (2012)

Article Cell & Tissue Engineering

Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells

Jiajie Xi et al.

STEM CELLS (2012)

Article Multidisciplinary Sciences

Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain

Maria Chiara G. Monaco et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2012)

Article Multidisciplinary Sciences

Investigating synapse formation and function using human pluripotent stem cell-derived neurons

Ji-Eun Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell & Tissue Engineering

Induced Differentiation of Neural Stem Cells of Astrocytic Origin to Motor Neurons in the Rat

Zhicheng Shao et al.

STEM CELLS AND DEVELOPMENT (2011)

Article Cell & Tissue Engineering

Purmorphamine Increases DARPP-32 Differentiation in Human Striatal Neural Stem Cells Through the Hedgehog Pathway

Gehan El-Akabawy et al.

STEM CELLS AND DEVELOPMENT (2011)

Article Clinical Neurology

Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development

Mario Maira et al.

JOURNAL OF NEURODEVELOPMENTAL DISORDERS (2010)

Article Neurosciences

Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain

Lachlan H. Thompson et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2009)

Article Biotechnology & Applied Microbiology

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Stuart M. Chambers et al.

NATURE BIOTECHNOLOGY (2009)

Article Biochemical Research Methods

Differentiation of human oligodendrocytes from pluripotent stem cells

Bao-Yang Hu et al.

NATURE PROTOCOLS (2009)

Article Neurosciences

Anatomical and functional reconstruction of the nigrostriatal pathway by intranigral transplants

Afsaneh Gaillard et al.

NEUROBIOLOGY OF DISEASE (2009)

Article Multidisciplinary Sciences

Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools

Milan Joksimovic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Cell & Tissue Engineering

Directed Differentiation of Human-Induced Pluripotent Stem Cells Generates Active Motor Neurons

Saravanan Karumbayaram et al.

STEM CELLS (2009)

Article Medicine, Research & Experimental

Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice

Clare L. Parish et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Multidisciplinary Sciences

An intrinsic mechanism of corticogenesis from embryonic stem cells

Nicolas Gaspard et al.

NATURE (2008)

Article Neurosciences

Re-examining the ontogeny of substantia nigra dopamine neurons

MA Gates et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2006)

Review Neurosciences

The floor plate: Multiple cells, multiple signals

M Placzek et al.

NATURE REVIEWS NEUROSCIENCE (2005)

Article Biotechnology & Applied Microbiology

Specification of motoneurons from human embryonic stem cells

XJ Li et al.

NATURE BIOTECHNOLOGY (2005)

Article Clinical Neurology

Isolation and transplantation of dopaminergic neurons and neural stem cells

H Okano et al.

PARKINSONISM & RELATED DISORDERS (2002)

Review Neurosciences

Opinion - Neural stem cell therapy for neurological diseases: dreams and reality

F Rossi et al.

NATURE REVIEWS NEUROSCIENCE (2002)

Article Developmental Biology

Regional specification of rodent and human neurospheres

T Ostenfeld et al.

DEVELOPMENTAL BRAIN RESEARCH (2002)

Article Multidisciplinary Sciences

Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity

H Kawasaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biotechnology & Applied Microbiology

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

SC Zhang et al.

NATURE BIOTECHNOLOGY (2001)

Review Multidisciplinary Sciences

The development of neural stem cells

S Temple

NATURE (2001)

Article Neurosciences

In vitro generation and transplantation of precursor-derived human dopamine neurons

R Sánchez-Pernaute et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2001)