☆ 4.7 Article

Cryo EM structures map a post vaccination polyclonal antibody response to canine parvovirus

COMMUNICATIONS BIOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Medicine, General & Internal

Trephine Minimally Invasive Procedure for Pilonidal Sinus

Itay Zoarets et al.

Summary: This study assessed the short- and long-term outcomes of the trephine procedure for pilonidal sinus. Short-term advantages include low morbidity and minimal impact on quality of life. However, the procedure has a significant long-term recurrence rate, indicating a need for further research.

ISRAEL MEDICAL ASSOCIATION JOURNAL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses

Jacob C. Milligan et al.

Summary: Researchers have discovered two antibodies that can neutralize and protect against Ebola virus and Sudan virus, providing potential clinical value in treating Ebola virus infections. These antibodies were found to recognize specific regions on the viral surface, offering a new approach for developing treatments against ebolaviruses.

CELL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

High-resolution structural analysis of enterovirus-reactive polyclonal antibodies in complex with whole virions

Aleksandar Antanasijevic et al.

Summary: This study introduces a cryo-electron microscopy-based method for structural analysis of virus- or vaccine-elicited polyclonal antibodies (pAbs) in complex with whole NPEV virions. The results demonstrate the feasibility of the method and identify potentially cross-reactive epitopes.

PNAS NEXUS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

From structure to sequence: Antibody discovery using cryoEM

Aleksandar Antanasijevic et al.

Summary: A hybrid approach combining structural and bioinformatic methods is presented for the identification and synthesis of monoclonal antibodies from serum-derived polyclonal antibodies, allowing for analysis of immune responses and iterative vaccine design.

SCIENCE ADVANCES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Localized reconstruction in Scipion expedites the analysis of symmetry mismatches in cryo-EM data

Vahid Abrishami et al.

Summary: Technological advances in transmission electron microscopes and detectors have made cryogenic electron microscopy an essential tool for structural biology. A method called single particle analysis is commonly used to determine the density map of macromolecular complexes, but dealing with symmetry mismatches in structures can be a challenge. Scipion, a cryo-EM image processing framework, has introduced a plugin called LocalRec to handle localized reconstruction for resolving asymmetric features.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2021)

添加到收藏夹

Article Biology

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

Ruben Sanchez-Garcia et al.

Summary: Sanchez-Garcia et al. introduce DeepEMhancer, a deep learning-based method for automatic post-processing of raw cryo-electron microscopy density maps. It globally improves local quality of density maps and shows potential as a useful tool for structures without readily available PDB models.

COMMUNICATIONS BIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

Eric F. Pettersen et al.

Summary: UCSF ChimeraX is a powerful visualization program with enhanced performance and graphics, offering new tools and analysis features, support for various areas like virtual reality, and improved ease of use, along with an app store for researchers to contribute new tools.

PROTEIN SCIENCE (2021)

添加到收藏夹

Article Cell Biology

Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination

Julianna Han et al.

Summary: This study extensively characterized the pAb response to HA after H5N1 immunization in humans using EM polyclonal epitope mapping (EMPEM). It found that cross-reactive pAbs originating from memory B cells persisted for over a year, while de novo pAb responses to multiple sites on the head of HA expanded after the second immunization but waned quickly.

CELL REPORTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility

Daniel J. Goetschius et al.

Summary: This study successfully achieved high resolution structure determination of HPV16 using a quasivirus approach, revealing dynamic structure and spatial movement characteristics of HPV, providing a framework for further biochemical and genetic research. The findings also offer insight into the resolution barrier in papillomavirus structural studies that had previously been a limitation.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

High-resolution asymmetric structure of a Fab-virus complex reveals overlap with the receptor binding site

Daniel J. Goetschius et al.

Summary: The study identified a significant overlap between the antigenic epitope and the receptor binding site of canine parvovirus, showing that specific antibody binding induces conformational changes to the virus. The findings highlight the potential of using cryo-EM to investigate complementarity of antibody binding.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Aleksandar Antanasijevic et al.

Summary: The authors proposed a method called cryoEMPEM for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. By applying this method in rhesus macaques, they were able to determine different polyclonal antibody structures and reveal new epitopes in the immune response.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Virology

Limited Intrahost Diversity and Background Evolution Accompany 40 Years of Canine Parvovirus Host Adaptation and Spread

Ian E. H. Voorhees et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Capsid-specific removal of circulating antibodies to adeno-associated virus vectors

Berangere Bertin et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Cell Biology

Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines

Bartek Nogal et al.

CELL REPORTS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

Christopher O. Barnes et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Transferrin receptor binds virus capsid with dynamic motion

Hyunwook Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Comparative immune responses of pups following modified live virus vaccinations against canine parvovirus

Jayalakshmi Vasu et al.

VETERINARY WORLD (2019)

添加到收藏夹

Article Virology

Complex and Dynamic Interactions between Parvovirus Capsids, Transferrin Receptors, and Antibodies Control Cell Infection and Host Range

Heather M. Callaway et al.

JOURNAL OF VIROLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Pushing the resolution limit by correcting the Ewald sphere effect in single-particle Cryo-EM reconstructions

Dongjie Zhu et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Biochemical Research Methods

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

Tristan Ian Croll

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2018)

添加到收藏夹

Article Immunology

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

Matteo Bianchi et al.

IMMUNITY (2018)

添加到收藏夹

Article Biochemical Research Methods

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani et al.

NATURE METHODS (2017)

添加到收藏夹

Article Virology

Single Mutations in the VP2 300 Loop Region of the Three-Fold Spike of the Carnivore Parvovirus Capsid Can Determine Host Range

Andrew B. Allison et al.

JOURNAL OF VIROLOGY (2016)

添加到收藏夹

Article Virology

Near-Atomic Resolution Structure of a Highly Neutralizing Fab Bound to Canine Parvovirus

Lindsey J. Organtini et al.

JOURNAL OF VIROLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

Serban L. Ilca et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cryo-EM study of Hepatitis B virus core antigen capsids decorated with antibodies from a human patient

Eaazhisai Kandiah et al.

JOURNAL OF STRUCTURAL BIOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

Sjors H. W. Scheres

JOURNAL OF STRUCTURAL BIOLOGY (2012)

添加到收藏夹

Article Virology

The Role of Evolutionary Intermediates in the Host Adaptation of Canine Parvovirus

Karla M. Stucker et al.

JOURNAL OF VIROLOGY (2012)

添加到收藏夹

Article Microbiology

Evolutionary Reconstructions of the Transferrin Receptor of Caniforms Supports Canine Parvovirus Being a Re-emerged and Not a Novel Pathogen in Dogs

Jason T. Kaelber et al.

PLOS PATHOGENS (2012)

添加到收藏夹

Article Biochemical Research Methods

MolProbity: all-atom structure validation for macromolecular crystallography

Vincent B. Chen et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

添加到收藏夹

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

添加到收藏夹

Article Biochemical Research Methods

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

添加到收藏夹

Article Virology

Structural Comparison of Different Antibodies Interacting with Parvovirus Capsids

Susan Hafenstein et al.

JOURNAL OF VIROLOGY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Interpretation of electron density with stereographic roadmap projections

Chuan Xiao et al.

JOURNAL OF STRUCTURAL BIOLOGY (2007)

添加到收藏夹

Article Multidisciplinary Sciences

Asymmetric binding of transferrin receptor to parvovirus capsids

Susan Hafenstein et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

添加到收藏夹

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.