4.6 Article

A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?

Iason Psilopatis et al.

Summary: Lung cancer is the leading cause of cancer death in the United States. Erythropoietin-producing hepatocellular receptors (EPHs) and their ligands ephrins play a defining role in the development and progression of lung cancer. Targeting EPHs/ephrins may provide effective treatment options for precision cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Review Biochemistry & Molecular Biology

Eph Receptors in Cancer

Sakshi Arora et al.

Summary: Eph receptor tyrosine kinases play critical roles in development and tissue formation, and are regulated by membrane-bound ligands ephrins. They have low expression in adults, but are often overexpressed in cancers, where they are associated with tumour development, vasculature, and invasion. Understanding the opposing roles of Ephs in different cancers is crucial for developing targeted therapies.

BIOMEDICINES (2023)

Article Pharmacology & Pharmacy

Pharmacological characterization of second generation FXR agonists as effective EphA2 antagonists: A successful application of target hopping approach

Francesca Romana Ferrari et al.

Summary: It has been demonstrated that the Eph-ephrin system, particularly the EphA2 receptor, plays a key role in supporting tumor growth, invasion, metastasis, and neovascularization. In this study, new commercially available FXR agonists, including Cilofexor, Nidufexor, Tropifexor, Turofexorate isopropyl, and Vonafexor, were characterized as potential Eph ligands. Molecular modeling investigations and binding assays showed that Cilofexor specifically and reversibly binds to the EphA2 receptor with a ki value in the low micromolar range.

BIOCHEMICAL PHARMACOLOGY (2023)

Article Chemistry, Medicinal

Targeting EPHA2 with Kinase Inhibitors in Colorectal Cancer

Alix Troster et al.

Summary: This concept paper describes the general strategies for EPHA2 inhibition with small molecules and summarizes the potential of targeting EPHA2 in CRC. EPHA2 plays a crucial role in the development and resistance mechanisms of CRC.

CHEMMEDCHEM (2023)

Article Oncology

Pretreatment of prostate cancer cells with salinomycin and Wnt inhibitor increases the efficacy of cabazitaxel by inducing apoptosis and decreasing cancer stem cells

Riza Serttas et al.

Summary: This study aimed to enhance the sensitivity of cabazitaxel in prostate cancer cell therapy by targeting cancer stem cells (CSCs) with a Wnt inhibitor and salinomycin pretreatment. The pretreatment effectively inhibited cell proliferation and migration, and eliminated CSCs, thereby increasing the efficacy of cabazitaxel therapy.

MEDICAL ONCOLOGY (2023)

Review Urology & Nephrology

Animal models of bone metastatic prostate cancer

Jong Hyun Tae et al.

Summary: The development of novel treatment agents for bone metastatic prostate cancer relies on understanding the underlying mechanisms of metastasis and treatment resistance. Animal models have played a vital role in cancer research, but current models only partially reproduce the process of bone metastasis. Therefore, knowledge of available models and their limitations is crucial for achieving research objectives.

INVESTIGATIVE AND CLINICAL UROLOGY (2023)

Article Oncology

Silencing Akt1 enhances the resistance of prostate cancer cells to starvation and inhibits starvation-induced lung metastasis through epithelial-mesenchymal transition in prostate cancer

Mei Yang et al.

Summary: This study investigates the effects of Akt1 and nutritional starvation (NST) on prostate cancer cells. The results show that silencing Akt1 enhances the resistance of cells to NST and maintains the mesenchymal state of cells through changes in epithelial-mesenchymal transition markers. Additionally, in vivo experiments demonstrate that silencing Akt1 inhibits lung metastasis formation.

MEDICAL ONCOLOGY (2022)

Article Oncology

Bone Targeting Agents in Patients with Prostate Cancer: General Toxicities and Osteonecrosis of the Jaw

Veronica Mollica et al.

Summary: Bone metastases are common in advanced prostate cancer cases and require close monitoring and prompt treatment. Bone targeting agents have shown benefits in reducing skeletal-related events and improving overall survival in castration-resistant prostate cancer, but they also carry important adverse events, including osteonecrosis of the jaw.

CURRENT ONCOLOGY (2022)

Review Oncology

The Role of the Eph Receptor Family in Tumorigenesis

Meg Anderton et al.

Summary: The Eph receptor family plays a dual role in tumorigenesis, acting as both promoters and suppressors depending on the context. EphA2 is particularly associated with Kaposi's sarcoma (KS) development and plays a significant role in this cancer type. Further research is needed to establish the links between EphA2 signaling and KS oncogenesis.

CANCERS (2021)

Review Biochemistry & Molecular Biology

The Clinical Impact of the EPH/Ephrin System in Cancer: Unwinding the Thread

Alexandros Pergaris et al.

Summary: The EPH/ephrin system plays a crucial role in the pathogenesis of diseases, including cancer, and is associated with clinical characteristics of malignant tumors, potentially serving as novel therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Pharmacology & Pharmacy

The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment

Oscar J. Buckens et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2020)

Article Pharmacology & Pharmacy

Ephrin or not? Six tough questions on Eph targeting

Carmine Giorgio et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2020)

Article Multidisciplinary Sciences

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

Giorgia Zadra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Pharmacology & Pharmacy

Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction

Carmine Giorgio et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

TGFβ-induced epithelial-to-mesenchymal transition in prostate cancer cells is mediated via TRPM7 expression

Yuyang Sun et al.

MOLECULAR CARCINOGENESIS (2018)

Review Chemistry, Medicinal

Targeting Eph/ephrin system in cancer therapy

Alessio Lodola et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Pharmacology & Pharmacy

Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation

Jose Alexandre Ferreira et al.

DRUG RESISTANCE UPDATES (2016)

Review Cell Biology

Mechanisms of ephrin-Eph signalling in development, physiology and disease

Artur Kania et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells

Sang-Hun Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Chemistry, Medicinal

Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system

Riccardo Castelli et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein-Protein Antagonists

Massimiliano Tognolini et al.

CHEMMEDCHEM (2014)

Article Multidisciplinary Sciences

Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation

Carmine Giorgio et al.

PLOS ONE (2011)

Article Endocrinology & Metabolism

PC3 Is a Cell Line Characteristic of Prostatic Small Cell Carcinoma

Sheng Tai et al.

PROSTATE (2011)

Article Cell & Tissue Engineering

EphB Signaling Controls Lineage Plasticity of Adult Neural Stem Cell Niche Cells

Tadashi Nomura et al.

CELL STEM CELL (2010)

Article Cell & Tissue Engineering

Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle

Maria Genander et al.

STEM CELLS (2010)

Article Multidisciplinary Sciences

Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors

Cynthia Kosinski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

EphA-ephrin-A-mediated β cell communication regulates insulin secretion from pancreatic islets

Irena Konstantinova et al.

Article Biochemistry & Molecular Biology

Potential clinical relevance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines

BP Fox et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Multidisciplinary Sciences

Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred

N Prevost et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)