Piper nigrum Extract Inhibits the Growth of Human Colorectal Cancer HT-29 Cells by Inducing p53-Mediated Apoptosis

Article Chemistry, Applied

Amide alkaloids characterization and neuroprotective properties of Piper nigrum L.: A comparative study with fruits, pericarp, stalks and leaves

Lan Yu et al.

Summary: The study identified diverse amide alkaloids in different parts of Piper nigrum L., with piperine being the most abundant compound known for its neuroprotective activities.

FOOD CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Effect of Rythmol (propafenone HCl) administration during pregnancy in Wistar rats

Entsar R. Abd-Allah et al.

Summary: This study investigated the potential teratogenic and genotoxic effects of propafenone during rat development. The results showed that propafenone treatment led to adverse effects on fetal development, including decreased weight, implantations and viable fetuses, and increased placental weight. Morphological abnormalities and ossification deficiency were observed in the treatment group, and histopathological changes were found in liver, kidney, and brain tissues of the treated fetuses. Furthermore, propafenone induced DNA damage in examined samples.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022)

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Review Oncology

Natural Products/Bioactive Compounds as a Source of Anticancer Drugs

Syeda Tasmia Asma et al.

Summary: Cancer is a deadly disease that has seen a significant rise in mortality rates globally. The search for potent anticancer agents has led to a focus on natural sources for novel and effective drugs. Plants and microbial species, chosen based on their composition, ecology, phytochemical, and ethnopharmacological properties, have played a crucial role in producing effective anticancer agents. The clinical development of various plant-derived bioactive compounds against cancer, as well as the conjugation of natural compounds with anti-cancerous drugs, show promise in generating targeted treatment therapies. Awareness from pharmaceutical research studies in this field could lead to alternative drug development strategies that are economical, reliable, and safe to use.

CANCERS (2022)

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Article Biochemistry & Molecular Biology

Anti-inflammatory activity and cytotoxicity against ovarian cancer cell lines by amide alkaloids and piperic esters isolated from Piper longum fruits: In vitro assessments and molecular simulation

Nguyen Viet Phong et al.

Summary: Five new compounds were isolated from the fruits of Piper longum L., along with 41 known compounds. The anti-inflammatory and cytotoxic activities of all isolated compounds were evaluated, and several compounds showed significant activity. Molecular docking simulations revealed the interaction and binding mechanisms of these active metabolites with proteins related to inflammation and cancer.

BIOORGANIC CHEMISTRY (2022)

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Article Chemistry, Medicinal

Anticancer Drugs for Intra-Arterial Treatment of Colorectal Cancer Liver Metastases: In-Vitro Screening after Short Exposure Time

Audrey Fohlen et al.

Summary: This study investigated the response of different cell lines to 12 cytotoxic agents, finding that idarubicin was the most cytotoxic to most colorectal cancer cell lines, while gemcitabine was most effective for certain cell lines. Interestingly, commonly used cytotoxic agents in the treatment of colorectal liver metastases showed limited cytotoxicity in the tested cell lines.

PHARMACEUTICALS (2021)

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Review Biology

Beneficial Effects of Betaine: A Comprehensive Review

Madan Kumar Arumugam et al.

Summary: This review discusses the protective effects of betaine in preventing liver disease and its therapeutic mechanism in alcohol-induced and metabolic-associated liver diseases. Betaine functions by regulating methionine metabolism and maintaining cellular function, providing protection against both liver- and non-liver-related diseases.

BIOLOGY-BASEL (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Chemistry, Medicinal

MicroRNA-Based Therapeutics for Drug-Resistant Colorectal Cancer

Eunsun Jung et al.

Summary: Research suggests that microRNAs may influence drug response in CRC patients by regulating drug resistance-related target genes, making them potential therapeutic targets or biomarkers. However, challenges exist in the clinical application of miRNAs as biomarkers and treatment targets for CRC.

PHARMACEUTICALS (2021)

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Article Multidisciplinary Sciences

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

Hudie Wei et al.

Summary: The structure of p53/BCL-xL complex reveals the molecular basis of their interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.

NATURE COMMUNICATIONS (2021)

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Review Pharmacology & Pharmacy

5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

Sona Vodenkova et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Article Oncology

CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling

Gao Lixia et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Food Science & Technology

Piperine sensitizes radiation-resistant cancer cells towards radiation and promotes intrinsic pathway of apoptosis

Koniyan Shaheer et al.

JOURNAL OF FOOD SCIENCE (2020)

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Review Food Science & Technology

Overview of the Anticancer Potential of the King of Spices Piper nigrum and Its Main Constituent Piperine

Eleonora Turrini et al.

TOXINS (2020)

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Article Pharmacology & Pharmacy

Effects of Oleamide on the Vasomotor Responses in the Rat

Carlos Hernandez-Diaz et al.

CANNABIS AND CANNABINOID RESEARCH (2020)

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Article Food Science & Technology

A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications

Heerasing Takooree et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

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Article Food Science & Technology

Effects of N-trans-feruloyltyramine isolated from laba garlic on antioxidant, cytotoxic activities and H2O2-induced oxidative damage in HepG2 and L02 cells

Xudong Gao et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

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Review Medicine, General & Internal

Colorectal cancer

Evelien Dekker et al.

LANCET (2019)

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Article Chemistry, Multidisciplinary

A selective and sensitive UFLC-MS/MS method for the simultaneous determination of five alkaloids from Piper longum L. and its application in the pharmacokinetic study of 6-OHDA-induced Parkinson's disease rats

Rongrong Xu et al.

RSC ADVANCES (2019)

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Article Chemistry, Medicinal

Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells

Young Sook Yun et al.

JOURNAL OF NATURAL MEDICINES (2018)

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Article Chemistry, Medicinal

Erucamide from Radish Leaves Has an Inhibitory Effect Against Acetylcholinesterase and Prevents Memory Deficit Induced by Trimethyltin

Cho Rong Kim et al.

JOURNAL OF MEDICINAL FOOD (2018)

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Article Agriculture, Multidisciplinary

An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice

Ines Reynoso-Moreno et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

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Article Medicine, Research & Experimental

(-)-Kusunokinin and piperloguminine from Piper nigrum: An alternative option to treat breast cancer

Somchai Sriwiriyajan et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Article Oncology

Anticancer and Cancer Prevention Effects of Piperine-Free Piper nigrum Extract on N-nitrosomethylurea-Induced Mammary Tumorigenesis in Rats

Somchai Sriwiriyajan et al.

CANCER PREVENTION RESEARCH (2016)

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Article Plant Sciences

Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells

Valdelucia Maria Alves de Souza Grinevicius et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

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Article Plant Sciences

Anti-cancer effects of Piper nigrum via inducing multiple molecular signaling in vivo and in vitro

Yan Deng et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

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Article Biochemistry & Molecular Biology

Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

Chi-Ping Day et al.

CELL (2015)

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Article Cell Biology

Piperine Suppresses the Expression of CXCL8 in Lipopolysaccharide-Activated SW480 and HT-29 Cells via Downregulating the Mitogen-Activated Protein Kinase Pathways

Xiao-Feng Hou et al.

INFLAMMATION (2015)

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Article Biochemistry & Molecular Biology

Piperine, an Alkaloid From Black Pepper, Inhibits Growth of Human Colon Cancer Cells Via G1 Arrest and Apoptosis Triggered by Endoplasmic Reticulum Stress

Paul B. Yaffe et al.

MOLECULAR CARCINOGENESIS (2015)

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Article Cell Biology

Anti-septic Effects of Pellitorine in HMGB1-Induced Inflammatory Responses In Vitro and In Vivo

Sae-Kwang Ku et al.

INFLAMMATION (2014)

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Review Chemistry, Medicinal

Piper nigrum and Piperine: An Update

Murlidhar Meghwal et al.

PHYTOTHERAPY RESEARCH (2013)

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Article Chemistry, Multidisciplinary

Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug

Gayong Shim et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Review Oncology

Apoptosis in cancer: from pathogenesis to treatment

Rebecca S. Y. Wong

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2011)

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Article Biochemistry & Molecular Biology

Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum

Gwendoline Cheng Lian Ee et al.

MOLECULES (2010)

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Article Physiology

Inhibitory Effect of Piperlonguminine/Dihydropiperlonguminine on the Production of Amyloid β and APP in SK-N-SH Cells

Hong-Shun Qi et al.

CHINESE JOURNAL OF PHYSIOLOGY (2009)

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Piper nigrum Extract Inhibits the Growth of Human Colorectal Cancer HT-29 Cells by Inducing p53-Mediated Apoptosis

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