4.6 Article

Towards Symmetric Thioamides: Microwave-Aided Synthesis of Terephthalic Acid Derivatives

期刊

PHARMACEUTICALS
卷 16, 期 7, 页码 -

出版社

MDPI
DOI: 10.3390/ph16070984

关键词

thioamides; terephthalic acid; thionation; microwave-accelerated synthesis; bis-terephthalthioamides

向作者/读者索取更多资源

The multistep synthesis of novel bis-terephthalthioamides based on methyl esters of amino acids was proposed using conventional heating and microwave-assisted approaches. The microwave-accelerated small-scale methodology resulted in significantly reduced reaction time, energy requirements, and slightly increased reaction yields when compared to conventional heating.
The multistep synthesis of novel bis-terephthalthioamides based on methyl esters of amino acids (AAs) was proposed using conventional heating and microwave-assisted approaches. In fact, the comparative case study on the thionation of new symmetrical diamides with Lawesson's reagent (LR) was performed. The microwave-accelerated small-scale methodology was successfully employed on the whole pathway from substrates (Gly, Ala, Val, Tyr, Ser) to products (symmetrical dithioamides of terephthalic acid), resulting in significantly reduced reaction time, energy requirements, and slightly increased reaction yields when compared to conventional heating. Moreover, the intermolecular similarity of novel terephthalic acid derivatives was estimated in the multidimensional space (mDS) of the structure/property-related in silico descriptors using principal component analysis (PCA) and hierarchical clustering analysis (HCA). The distance-oriented structure/property distribution was also correlated with the experimental lipophilic data.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据