期刊
NATURE REVIEWS DRUG DISCOVERY
卷 15, 期 8, 页码 533-550出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd.2016.29
关键词
-
资金
- Wellcome Trust
Protein-protein interactions (PPIs) are of pivotal importance in the regulation of biological systems and are consequently implicated in the development of disease states. Recent work has begun to show that, with the right tools, certain classes of PPI can yield to the efforts of medicinal chemists to develop inhibitors, and the first PPI inhibitors have reached clinical development. In this Review, we describe the research leading to these breakthroughs and highlight the existence of groups of structurally related PPIs within the PPI target class. For each of these groups, we use examples of successful discovery efforts to illustrate the research strategies that have proved most useful.
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