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Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response
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Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN-β production
T Nakamura et al.
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EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in TH1 cells
M Koyanagi et al.
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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
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Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis
S Camelo et al.
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Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs
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I Su et al.
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Trichostatin A attenuates airway inflammation in mouse asthma model
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Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
IV Gregoretti et al.
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P Reddy et al.
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M Yamashita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
A distinct region of the murine IFN-γ promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells
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Differential regulation of P-selectin ligand expression in naive versus memory CD4+ T cells:: evidence for epigenetic regulation of involved glycosyltransferase genes
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AC Bell et al.
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