Inhibition of the serine/threonine kinase BUB1 reverses taxane resistance in prostate cancer

Article Oncology

Discovery of a new candidate drug to overcome cabazitaxel-resistant gene signature in castration-resistant prostate cancer by in silico screening

Hiroshi Hongo et al.

Summary: Pimozide appears to be a promising drug to overcome docetaxel-resistant castration-resistant prostate cancer (CRPC) by targeting AURKB and KIF20A.

PROSTATE CANCER AND PROSTATIC DISEASES (2023)

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Article Medicine, General & Internal

Circulating tumor cell gene expression and plasma AR gene copy number as biomarkers for castration-resistant prostate cancer patients treated with cabazitaxel

Giorgia Gurioli et al.

Summary: This study evaluated the prognostic role of CTC gene expression in cabazitaxel-treated mCRPC patients and its association with plasma AR copy number. The results showed that CTC gene expression was significantly associated with overall survival and disease progression. AR-V7 was identified as an important prognostic biomarker, and patients with AR-V7 positivity had poorer outcomes with lower dose cabazitaxel treatment.

BMC MEDICINE (2022)

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Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Article Oncology

Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism

Liang Chen et al.

Summary: Our study revealed the interaction between circ_0004087 and the mitosis error correction mechanism, showing that circ_0004087 can stimulate the expression of BUB1 through SND1 and MYB, leading to enhanced mitotic accuracy of PCa cells. Furthermore, circ_0004087 was found to confer DTX resistance in PCa cells, suggesting its potential as a prognostic biomarker and therapeutic target in DTX-resistant PCa patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Oncology

bub1 as a potential oncogene and a prognostic biomarker for neuroblastoma

Jingjing Song et al.

Summary: In this study, a potential tumor-promoting gene bub1 for neuroblastoma was identified and found to also serve as a prognostic biomarker. The bub1 gene was shown to promote cancer progression in neuroblastoma by regulating important downstream molecules related to apoptosis and epithelial-mesenchymal transition.

FRONTIERS IN ONCOLOGY (2022)

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Article Biology

Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences

Walter Rayford et al.

Summary: Racial disparities in prostate cancer were investigated in a multi-institutional retrospective analysis of African-American and European-American men who underwent radical prostatectomy. Differences were found in gene expression with African-American men showing higher expression of inflammation genes and lower expression of mismatch repair genes.

COMMUNICATIONS BIOLOGY (2021)

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Review Endocrinology & Metabolism

Hormonal Therapy for Prostate Cancer

Kunal Desai et al.

Summary: Huggins and Hodges demonstrated the therapeutic effect of gonadal testosterone deprivation in the 1940s, leading to the concept of prostate cancer being highly androgen-dependent. Since then, hormonal therapy has evolved from gonadal testosterone deprivation to inhibiting extragonadal androgens, to directly binding and inhibiting the androgen receptor. Today's standard of care for advanced prostate cancer includes gonadotropin-releasing hormone agonists and androgen receptor antagonists.

ENDOCRINE REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Androgen receptor splicing variant 7 (ARV7) inhibits docetaxel sensitivity by inactivating the spindle assembly checkpoint

Bingbing Yu et al.

Summary: The study revealed that ARV7 mediates DTX sensitivity by inactivating SAC and promoting mitotic slippage, leading to resistance. By regulating E2 enzyme UBE2C, ARV7 plays a role in promoting SAC inactivation and early degradation of cyclin B1. Combination treatment of DTX and a mitotic exit inhibitor shows a synergistic effect in high ARV7-expressing prostate cancer cells.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Oncology

BUB1 drives the occurrence and development of bladder cancer by mediating the STAT3 signaling pathway

Ning Jiang et al.

Summary: The study revealed that increased expression of BUB1 in human bladder cancer was associated with the activation of STAT3 signaling. Inhibition of BUB1 kinase activity effectively suppressed BCa cell proliferation and cancer progression both in vitro and in vivo. The BUB1/STAT3 complex played a critical role in promoting the transcription of STAT3 target genes, highlighting the potential of BUB1 as a therapeutic target for bladder cancer treatment.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Multidisciplinary Sciences

Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

Yael Cohen-Sharir et al.

Summary: The study shows that aneuploid cancer cells are more sensitive to genetic perturbation of SAC components and their long-term proliferation is jeopardized. Furthermore, aneuploid cells exhibit aberrant spindle geometry and dynamics, which result in mitotic defects and less-fit karyotypes over time.

NATURE (2021)

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Article Multidisciplinary Sciences

Whole-genome doubling confers unique genetic vulnerabilities on tumour cells

Ryan J. Quinton et al.

Summary: Whole-genome doubling (WGD) in human cancers results in genetically unstable tetraploid cells that depend on specific signaling pathways and require the KIF18A gene for viability. Targeting vulnerabilities unique to WGD(+) cells presents a potential strategy for cancer therapy.

NATURE (2021)

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Article Multidisciplinary Sciences

Topoisomerase II alpha inhibition can overcome taxane-resistant prostate cancer through DNA repair pathways

Hiroshi Hongo et al.

Summary: The study identified etoposide as a promising treatment candidate for CBZ-resistant CRPC by inhibiting TOP2A expression, which could potentially be an optimal treatment for CRPC in the post-CBZ setting.

SCIENTIFIC REPORTS (2021)

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Article Oncology

KIF4A knockdown suppresses ovarian cancer cell proliferation and induces apoptosis by downregulating BUB1 expression

Wumin Jin et al.

Summary: The study elucidated that KIF4A suppresses ovarian cancer progression by regulating BUB1, with KIF4A knockdown significantly inhibiting cell viability, colony formation, and migration, while inducing apoptosis. The results suggest the potential therapeutic value of KIF4A and BUB1 as targets for ovarian cancer treatment.

MOLECULAR MEDICINE REPORTS (2021)

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Review Pharmacology & Pharmacy

Future prospects for mitosis-targeted antitumor therapies

Alfonso Serrano-del Valle et al.

Summary: Developing new therapies targeting cell cycle regulation and mitosis has shown potential, despite many being discontinued during clinical trials. Future efforts could focus on increasing cell death signals, targeting senescent cells, and promoting antitumor immune response to enhance the efficacy of these treatments.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Cell Biology

Inhibition of BUB1 suppresses tumorigenesis of osteosarcoma via blocking of PI3K/Akt and ERK pathways

Zhen Huang et al.

Summary: BUB1 is overexpressed in osteosarcoma and closely associated with poor clinical outcomes. Inhibition of BUB1 significantly suppresses cell proliferation and tumor growth, cell migration, invasion, and induces apoptosis in osteosarcoma by blocking the PI3K/Akt and ERK signaling pathways.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Oncology

LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance

Melyssa S. Roberts et al.

CANCER RESEARCH (2020)

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Article Cell Biology

Androgen Receptor and Its Splicing Variant 7 Expression in Peripheral Blood Mononuclear Cells and in Circulating Tumor Cells in Metastatic Castration-Resistant Prostate Cancer

Mercedes Marin-Aguilera et al.

CELLS (2020)

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Article Oncology

TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling

Shyam Nyati et al.

NEOPLASIA (2020)

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Editorial Material Oncology

Prostate Cancer 2020: The Times They Are a'Changing''

Alec Paschalis et al.

CANCER CELL (2020)

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Review Oncology

Mechanisms of Taxane Resistance

Sara M. Maloney et al.

CANCERS (2020)

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Article Medicine, Research & Experimental

TGF-β causes Docetaxel resistance in Prostate Cancer via the induction of Bcl-2 by acetylated KLF5 and Protein Stabilization

Yixiang Li et al.

THERANOSTICS (2020)

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Article Multidisciplinary Sciences

Aneuploidy drives lethal progression in prostate cancer

Konrad H. Stopsack et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Multidisciplinary Sciences

Genomic correlates of clinical outcome in advanced prostate cancer

Wassim Abida et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Cell Biology

Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer

Ning Zhao et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Multidisciplinary Sciences

Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer

Antonio Giordano et al.

PLOS ONE (2019)

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Article Multidisciplinary Sciences

Taxane-based Chemotherapy Induced Androgen Receptor Splice Variant 7 in Patients with Castration-Resistant Prostate Cancer: A Tissue-based Analysis

Myungsun Shim et al.

SCIENTIFIC REPORTS (2019)

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Article Oncology

Expression of AR-V7 and ARv567es in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY

Scott T. Tagawa et al.

CLINICAL CANCER RESEARCH (2019)

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Article Oncology

Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo

Gerhard Siemeister et al.

CLINICAL CANCER RESEARCH (2019)

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Editorial Material Cell Biology

Anti-mitotic therapies in cancer

Julia Tischer et al.

JOURNAL OF CELL BIOLOGY (2019)

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Article Medicine, Research & Experimental

Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer

Adam Sharp et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Oncology

Cotargeting Plk1 and androgen receptor enhances the therapeutic sensitivity of paclitaxel-resistant prostate cancer

Sol-Bi Shin et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2019)

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Review Andrology

Role of chemotherapy in prostate cancer

Rita Nader et al.

ASIAN JOURNAL OF ANDROLOGY (2018)

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Article

Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines

Kazuaki Machioka et al.

Oncotarget (2018)

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Article Oncology

Collateral resistance to taxanes in enzalutamide-resistant prostate cancer through aberrant androgen receptor and its variants

Masaki Shiota et al.

CANCER SCIENCE (2018)

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Article Biochemistry & Molecular Biology

Identification of an oncogenic network with prognostic and therapeutic value in prostate cancer

Fiorella Magani et al.

MOLECULAR SYSTEMS BIOLOGY (2018)

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Article Urology & Nephrology

DESNT: A Poor Prognosis Category of Human Prostate Cancer

Bogdan-Alexandru Luca et al.

EUROPEAN UROLOGY FOCUS (2018)

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Article Multidisciplinary Sciences

Basis of catalytic assembly of the mitotic checkpoint complex

Alex C. Faesen et al.

NATURE (2017)

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Article Biochemistry & Molecular Biology

Phenotype transformation of immortalized NCM460 colon epithelial cell line by TGF-β1 is associated with chromosome instability

Chao Huang et al.

MOLECULAR BIOLOGY REPORTS (2016)

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Article Biochemistry & Molecular Biology

Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer

Akash Kumar et al.

NATURE MEDICINE (2016)

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Article Biology

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

Anna P. baron et al.

ELIFE (2016)

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Article Oncology

Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer

Howard I. Scher et al.

JAMA ONCOLOGY (2016)

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Editorial Material Biochemistry & Molecular Biology

The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-β signaling apparatus

Aristidis Moustakas

SCIENCE SIGNALING (2015)

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Article Biochemistry & Molecular Biology

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling

Shyam Nyati et al.

SCIENCE SIGNALING (2015)

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Article Oncology

Androgen receptor splice variants circumvent AR blockade by microtubule-targeting agents

Guanyi Zhang et al.

ONCOTARGET (2015)

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Editorial Material Biochemistry & Molecular Biology

The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-β signaling apparatus

Aristidis Moustakas

SCIENCE SIGNALING (2015)

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Article Biochemistry & Molecular Biology

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling

Shyam Nyati et al.

SCIENCE SIGNALING (2015)

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Article Medicine, General & Internal

Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study

H. Ross-Adams et al.

EBIOMEDICINE (2015)

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Article Oncology

Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer

Maria Thadani-Mulero et al.

CANCER RESEARCH (2014)

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Article Oncology

Targeting CDC25C, PLK1 and CHK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer

Nader Al Nakouzi et al.

ONCOTARGET (2014)

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Article Medicine, Research & Experimental

ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer

Changmeng Cai et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Oncology

Cabazitaxel: More Than a New Taxane for Metastatic Castrate-Resistant Prostate Cancer?

Alain C. Mita et al.

CLINICAL CANCER RESEARCH (2012)

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Article Multidisciplinary Sciences

The mutational landscape of lethal castration-resistant prostate cancer

Catherine S. Grasso et al.

NATURE (2012)

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Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

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Article Oncology

Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer

Medha S. Darshan et al.

CANCER RESEARCH (2011)

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Review Biochemistry & Molecular Biology

BUB1 and BUBR1: multifaceted kinases of the cell cycle

Victor M. Bolanos-Garcia et al.

TRENDS IN BIOCHEMICAL SCIENCES (2011)

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Article Oncology

Integrative Genomic Profiling of Human Prostate Cancer

Barry S. Taylor et al.

CANCER CELL (2010)

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Article Oncology

Transforming growth factor β1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells

Wen Deng et al.

CANCER RESEARCH (2008)

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Article Endocrinology & Metabolism

The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines

Masashi Takeda et al.

PROSTATE (2007)

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Article Cell Biology

Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms

D Cimini et al.

JOURNAL OF CELL SCIENCE (2003)

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Article Cell Biology

Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

D Cimini et al.

JOURNAL OF CELL BIOLOGY (2001)

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Inhibition of the serine/threonine kinase BUB1 reverses taxane resistance in prostate cancer

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