4.7 Article

Guanylate-binding protein 1 modulates proteasomal machinery in ovarian cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Protein degradation: expanding the toolbox to restrain cancer drug resistance

Hui Ming et al.

Summary: Despite progress in clinical management, drug resistance remains a major obstacle. Research on protein degradation has gained attention and several therapeutic strategies have been developed. Targeting the degradation process seems to be a more rapid and direct strategy compared to transcriptional intervention.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2023)

Article Biochemistry & Molecular Biology

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

Yasset Perez-Riverol et al.

Summary: PRIDE is the largest data repository of mass spectrometry-based proteomics data in the world, with around 500 datasets submitted per month. In addition to continuous improvements in data pipelines and infrastructure, PRIDE has developed the Spectra Archive and MAGE-TAB file format to enhance sample metadata annotation and access to mass spectra.

NUCLEIC ACIDS RESEARCH (2022)

Article Biochemistry & Molecular Biology

Intracellular localization of the proteasome in response to stress conditions

Cordula Enenkel et al.

Summary: Under cellular stress conditions, the localization of the ubiquitin-proteasome system undergoes changes, with proteasomes accumulating in membraneless granules in the nucleus or cytoplasm, or forming reversible proteasome structures through liquid-liquid phase separation in the nucleus.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

Marlene F. Schmidt et al.

Summary: Neurodegenerative diseases are characterized by progressive nervous system damage, such as the selective loss of vulnerable neurons, leading to motor symptoms and cognitive decline. The primary risk factor for these diseases is aging, which results in reduced proteasomal degradation and autophagy, leading to the accumulation of neurotoxic protein aggregates. Ubiquitin plays a critical role in both degradation pathways and non-degradative signaling, implicating it as a potential target for new drugs to treat neurodegenerative diseases.

CELL DEATH AND DIFFERENTIATION (2021)

Article Biochemistry & Molecular Biology

FunRich enables enrichment analysis of OMICs datasets

Pamali Fonseka et al.

Summary: High-throughput methods for profiling various biological systems have become routine in research laboratories worldwide. The FunRich tool enables biologists to perform functional enrichment analysis on generated datasets with customizable visualizations. It allows users to update background databases from UniProt, supporting annotations from over 18 taxonomies.

JOURNAL OF MOLECULAR BIOLOGY (2021)

Article Biochemistry & Molecular Biology

CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics

Augustin Luna et al.

Summary: CellMiner Cross-Database (CellMinerCDB) allows integration and analysis of cancer cell line datasets from various sources, with the latest version 1.2 including new and updated datasets, support for pattern comparisons and multivariate analyses, improved annotations, analysis speedups, new dataset download feature, enhanced visualization, breakdown of associations by tissue type, and improved help information. This common curation and annotations across datasets increase the utility for various researcher question types, including data reproducibility, biomarker discovery, and multivariate analysis of drug activity.

NUCLEIC ACIDS RESEARCH (2021)

Article Multidisciplinary Sciences

The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag

Indrajit Sahu et al.

Summary: The study demonstrates that 20S proteasomes can degrade not only the ubiquitin tag but also the conjugated substrate, leading to the identification of ubiquitin remnants on branched peptide products. Peptidomics reveals proteasome-trapped ubiquitin-derived peptides and potential 20S substrates in different cellular conditions, indicating the potential involvement of elevated levels of 20S proteasomes in cell survival under stress.

NATURE COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Thermal proteome profiling for interrogating protein interactions

Andre Mateus et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

Article Oncology

Oncogenic Role of Guanylate Binding Protein 1 in Human Prostate Cancer

Jing Zhao et al.

FRONTIERS IN ONCOLOGY (2020)

Review Immunology

Guanylate-Binding Protein 1: An Emerging Target in Inflammation and Cancer

Alexander T. Honkala et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Oncology

GBP1 promotes erlotinib resistance via PGK1-activated EMT signaling in non-small cell lung cancer

Lifang Cheng et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis

Daniel Fisch et al.

EMBO JOURNAL (2019)

Review Biochemistry & Molecular Biology

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

Dimakatso Alice Senthebane et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Oncology

Proteasome inhibitors in cancer therapy

Elisabet E. Manasanch et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Review Biochemistry & Molecular Biology

Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease

Danielle Pilla-Moffett et al.

JOURNAL OF MOLECULAR BIOLOGY (2016)

Article Biochemical Research Methods

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

Stefka Tyanova et al.

NATURE PROTOCOLS (2016)

Article Biochemical Research Methods

General Statistical Framework for Quantitative Proteomics by Stable Isotope Labeling

Pedro Navarro et al.

JOURNAL OF PROTEOME RESEARCH (2014)

Article Multidisciplinary Sciences

Tracking cancer drugs in living cells by thermal profiling of the proteome

Mikhail M. Savitski et al.

SCIENCE (2014)

Article Cell Biology

Class III β-tubulin and the cytoskeletal gateway for drug resistance in ovarian cancer

Marta De Donato et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2012)

Review Cell Biology

Protein degradation and the stress response

Karin Flick et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)

Article Oncology

Optimal treatment for relapsing ovarian cancer

J. A. Ledermann et al.

ANNALS OF ONCOLOGY (2010)

Article Biochemistry & Molecular Biology

A ubiquitin stress response induces altered proteasome composition

John Hanna et al.

Article Oncology

GBP1 overexpression is associated with a paclitaxel resistance phenotype

ZF Duan et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)

Article Multidisciplinary Sciences

Drug resistance in cancer: Principles of emergence and prevention

NL Komarova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)