4.7 Article

The CPT1A/Snail axis promotes pancreatic adenocarcinoma progression and metastasis by activating the glycolytic pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Cell Biology

The short-chain fatty acid acetate modulates epithelial-to-mesenchymal transition

Junfang Lyu et al.

Summary: Normal tissue and organ morphogenesis require epithelial cell plasticity and conversion to a mesenchymal phenotype through a process known as epithelial-to-mesenchymal transition (EMT). This study demonstrates that EMT induced by transforming growth factor beta (TGF-beta) is accompanied by reduced fatty acid oxidation (FAO) and decreased levels of acetyl-coenzyme A (acetyl-CoA). Acetate, a short-chain fatty acid, effectively inhibits EMT and cancer cell migration by increasing acetyl-CoA levels and restoring α-tubulin acetylation. These findings suggest that acetate is a potent metabolic regulator of EMT and targeting acetate metabolism could have therapeutic potential for EMT-related pathological conditions.

MOLECULAR BIOLOGY OF THE CELL (2022)

Article Multidisciplinary Sciences

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

Jessica K. Nelson et al.

Summary: This study reveals that the deubiquitinating enzyme USP25 promotes growth and survival of pancreatic ductal adenocarcinoma (PDAC) by stabilizing and regulating the transcriptional activity of HIF-1 protein. PDAC is characterized by a severely hypoxic microenvironment, and inhibition of USP25 impairs HIF-1 activity and induces cell death in the tumor core. The USP25/HIF-1α axis may be a potential therapeutic target for PDAC.

NATURE COMMUNICATIONS (2022)

Article Oncology

Exosomal CD44 Transmits Lymph Node Metastatic Capacity Between Gastric Cancer Cells via YAP-CPT1A-Mediated FAO Reprogramming

Mei Wang et al.

Summary: Exosomal CD44 transmits lymph node metastasis (LNM) capacity between gastric cancer (GC) cells via the RhoA/YAP/Prox1/CPT1A signaling axis. Abnormal expression of CD44/YAP/CPT1A is associated with LNM status, stages, invasion, and poor survival in GC patients.

FRONTIERS IN ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis

Tian Tian et al.

Summary: In this study, researchers found that the key enzyme carnitine O-palmitoyl transferase 1 (CPT1A) is upregulated in advanced esophageal squamous cell carcinoma (ESCC) and is associated with poor survival. Overexpression of CPT1A protects ESCC cells from apoptosis by maintaining redox homeostasis through supply of GSH and NADPH. The transcription factor ETV4 and ubiquitin enzyme RNF2 play important roles in regulating the expression of CPT1A. Disrupting CPT1A prevents NADPH supply and inhibits the anchorage-independent growth of ESCC cells and their lung metastases. These findings provide insights into the metastasis of ESCC and suggest a link between anoikis resistance and fatty acid oxidation.

REDOX BIOLOGY (2022)

Article Cell Biology

Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy

Ning Jiang et al.

Summary: The study found that inhibiting Cpt1a can alleviate chondrocyte senescence and osteoarthritis, promoting mitochondrial function and providing a new therapeutic strategy.

MECHANISMS OF AGEING AND DEVELOPMENT (2022)

Article Pharmacology & Pharmacy

Glycolysis-Related LINC02432/Hsa-miR-98-5p/HK2 Axis Inhibits Ferroptosis and Predicts Immune Infiltration, Tumor Mutation Burden, and Drug Sensitivity in Pancreatic Adenocarcinoma

Peng Tan et al.

Summary: This study identified a novel glycolysis-related ceRNA signature and investigated its potential biological functions in PAAD. The findings suggest that the LINC02432/hsa-miR-98-5p/HK2 axis may play important roles in the diagnosis, prognosis, and treatment of PAAD.

FRONTIERS IN PHARMACOLOGY (2022)

Article Biotechnology & Applied Microbiology

miR-22 Suppresses EMT by Mediating Metabolic Reprogramming in Colorectal Cancer through Targeting MYC-Associated Factor X

Shusen Xia et al.

Summary: This study revealed that miR-22 is hypermethylated and downregulated, while MAX is upregulated in colorectal cancer. miR-22 participates in the progression of colorectal cancer by inhibiting migration, invasion, glycolysis, and cancer stem cell transcription factors.

DISEASE MARKERS (2022)

Article Cell Biology

FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis

Kun Cai et al.

Summary: FOXD1 overexpression in pancreatic cancer is associated with adverse prognostic index and enhances aerobic glycolysis, proliferation, invasion, and metastasis of cancer cells.

CELL DEATH & DISEASE (2022)

Article Medicine, Research & Experimental

AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy

Changqing Wu et al.

Summary: Increased lipid droplet formation has been linked to tumor metastasis, stemness, and chemoresistance in various types of cancer. The study reveals that AKR1C3-dependent lipid droplet accumulation is critical for the adaptation to sorafenib in HCC cells by regulating lipid and energy homeostasis. Targeting AKR1C3 might be a promising therapeutic strategy for HCC tumors.

THERANOSTICS (2022)

Article Oncology

LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway

Fengyu Xu et al.

Summary: The reciprocal feedback loop between HIF1A-AS1 and HIF1 alpha promotes gemcitabine resistance in pancreatic cancer, highlighting a potential therapeutic target.

CANCER RESEARCH (2021)

Article Oncology

HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer

Xin Guo et al.

Summary: Dependence on glutamine and acceleration of fatty acid oxidation are metabolic characteristics of triple-negative breast cancer. HRD1 acts as a regulatory protein for FAO, inhibiting TNBC cell proliferation under glutamine-deficient conditions. This finding provides insight into HRD1 as a regulator of lipid metabolism for potential therapeutic targeting in TNBC.

MOLECULAR ONCOLOGY (2021)

Article Oncology

PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells

Ji Hyeon You et al.

Summary: The study highlights that PGRMC1 promotes ferroptosis in paclitaxel-tolerant persister cancer cells (PCC) by affecting lipid metabolism and xCT inhibition. These findings reveal the mechanism of PGRMC1 in regulating ferroptosis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Oncology

Enhancing cancer-associated fibroblast fatty acid catabolism within a metabolically challenging tumor microenvironment drives colon cancer peritoneal metastasis

Shaoyong Peng et al.

Summary: The study revealed decreased key enzymes of fatty acid oxidation in patients with peritoneal metastatic colorectal cancer, impacting lipid metabolism. Cancer-associated fibroblasts promote the proliferation, migration, and invasion of colon cancer cells by upregulating CPT1A. Inhibition of glycolysis reduces CRC cell survival and directly blocking FAO in CAFs with etomoxir inhibits migration and invasion, suggesting a potential novel approach against CAF-induced colorectal cancer with peritoneal dissemination.

MOLECULAR ONCOLOGY (2021)

Review Gastroenterology & Hepatology

Pancreatic cancer: A review of epidemiology, trend, and risk factors

Jian-Xiong Hu et al.

Summary: Pancreatic cancer remains highly lethal with low survival rates and difficulty in early detection. The incidence and mortality of pancreatic cancer are increasing worldwide, and understanding the risk factors is crucial for prevention.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Article Cell Biology

Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer

Dongqing Huang et al.

Summary: Resistance to platinum compounds is a major factor affecting patient survival in high-grade serous ovarian cancer. By analyzing multiomic data from HGSOC cells, this study identified that increased fatty acid oxidation pathway expression and inhibition of the key enzyme CPT1A can sensitize ovarian cancer cells to platinum. The results were further validated in patient-derived xenograft models, indicating CPT1A as a potential therapeutic target to overcome platinum resistance.

CELL REPORTS MEDICINE (2021)

Article Biochemistry & Molecular Biology

Targeted Inhibition of LPL/FABP4/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer

Haoran Yang et al.

Summary: The upregulation of the LPL/FABP4/CPT1 molecular axis during NASH phase is specific and inhibiting it can delay tumor growth and significantly reduce the viability of liver cancer stem cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

CPT1A and fatty acid β-oxidation are essential for tumor cell growth and survival in hormone receptor-positive breast cancer

Nidhi Jariwala et al.

Summary: The amplification of chromosome 11q13-14 and overexpression of CPT1A are associated with aggressive luminal breast tumors, tumor proliferation, and poor prognosis. Inhibition of FAO, an essential process involving CPT1A, is effective in preventing tumor growth and promoting apoptosis in luminal breast cancer cells. These findings suggest that targeting FAO may be a potential therapeutic strategy for HR+ breast cancer treatment.

NAR CANCER (2021)

Review Endocrinology & Metabolism

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

Isabel R. Schlaepfer et al.

ENDOCRINOLOGY (2020)

Review Biochemistry & Molecular Biology

Metabolism of pancreatic cancer: paving the way to better anticancer strategies

Cheng Qin et al.

MOLECULAR CANCER (2020)

Review Oncology

Regulation of Autophagy by Glycolysis in Cancer

Ying Chu et al.

CANCER MANAGEMENT AND RESEARCH (2020)

Article Medicine, Research & Experimental

STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma

Huakan Zhao et al.

THERANOSTICS (2020)

Review Oncology

EMT and Stemness-Key Players in Pancreatic Cancer Stem Cells

Eva Rodriguez-Aznar et al.

CANCERS (2019)

Article Cell Biology

CPT1A-mediated succinylation of S100A10 increases human gastric cancer invasion

Chao Wang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Article Medicine, Research & Experimental

CPT1A regulates breast cancer-associated lymphangiogenesis via VEGF signaling

Yiquan Xiong et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Oncology

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

Thomas M. Ashton et al.

CLINICAL CANCER RESEARCH (2018)

Article Medicine, Research & Experimental

Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy

Zheqiong Tan et al.

THERANOSTICS (2018)

Article Gastroenterology & Hepatology

Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

Ziying Jian et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Cell Biology

Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells

Hengqiang Zhao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

Jae-Seok Roe et al.

Article Endocrinology & Metabolism

Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer

Dana K. Andersen et al.

DIABETES (2017)

Review Biochemistry & Molecular Biology

Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism

Paolo E. Porporato et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Biochemistry & Molecular Biology

Diabetes and pancreatic cancer

Donghui Li

MOLECULAR CARCINOGENESIS (2012)

Article Multidisciplinary Sciences

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

Sang-Min Jeon et al.

NATURE (2012)

Article Medicine, General & Internal

Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers

RZ Stolzenberg-Solomon et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)