期刊
NATURE REVIEWS CLINICAL ONCOLOGY
卷 14, 期 4, 页码 247-258出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrclinonc.2016.183
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资金
- ANR
- Canceropole Ile-de-France
- European Commission (ArtForce)
- European Research Council (ERC)
- Fondation Bettencourt Schueller
- Fondation de France
- French Agence National de la Recherche (ANR) - Projets Blancs
- French Association pour la recherche sur le cancer (ARC)
- French Fondation pour la Recherche Medicale (FRM)
- French Institut National du Cancer (INCa)
- French Ligue contre le Cancer (equipe labellisee)
- LabEx Immuno-Oncology
- Paris Alliance of Cancer Research Institutes (PACRI)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- SIRIC (Sites de Recherche Integree sur le Cancer) Stratified Oncology Cell DNA Repair and Tumour Immune Elimination (SOCRATE)
- Swiss Bridge Foundation
- Swiss Institute for Experimental Cancer Research (ISREC)
- Breast Cancer Research Foundation
- Chemotherapy Foundation
- US National Institutes of Health [R01 CA201246, R01 CA198533]
- US Department of Defence Breast Cancer Research Program [W81XWH-11-1-0530]
Autophagy is fundamental to the maintenance of intracellular homeostasis in virtually all human cells. Accordingly, defective autophagy predisposes healthy cells to undergoing malignant transformation. By contrast, malignant cells are able to harness autophagy to thrive, despite adverse microenvironmental conditions, and to resist therapeutic challenges. Thus, inhibition of autophagy has been proposed as a strategy to kill cancer cells or sensitize them to therapy; however, autophagy is also critical for optimal immune function, and mediates cell-extrinsic homeostatic effects owing to its central role in danger signalling by neoplastic cells responding to immunogenic chemotherapy and/or radiation therapy. In this Perspective, we discuss accumulating preclinical and clinical evidence in support of the all-too-often dismissed possibility that activating autophagy might be a relevant clinical objective that enables an increase in the effectiveness of immunogenic chemotherapy and/or radiation therapy.
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