Investigating Acute Hepatitis after SARS-CoV-2 Vaccination or Infection: A Genetic Case Series

Summary: Autoimmune manifestations have been reported in response to certain COVID-19 vaccines, but it is still unclear whether there is a causal relationship. These reports can help guide the clinical assessment and management of autoimmune manifestations after vaccination.

IMMUNOLOGY (2022)

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Letter Gastroenterology & Hepatology

A typical autoimmune hepatitis (AIH) case following Covid-19 mRNA vaccination. More than a coincidence?

Anestis Goulas et al.

LIVER INTERNATIONAL (2022)

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Article Gastroenterology & Hepatology

Clinical features of patients with new onset of autoimmune hepatitis following SARS-CoV-2 vaccination

C. Rigamonti et al.

DIGESTIVE AND LIVER DISEASE (2022)

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Letter Gastroenterology & Hepatology

New-onset autoimmune hepatitis following mRNA COVID-19 vaccination in a 36-year-old woman with primary sclerosing cholangitis - should we be more vigilant?

Taotao Zhou et al.

JOURNAL OF HEPATOLOGY (2022)

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Letter Gastroenterology & Hepatology

Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed

Gloria Shwe Zin Tun et al.

JOURNAL OF HEPATOLOGY (2022)

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Letter Gastroenterology & Hepatology

Severe de novo liver injury after Moderna vaccination - not always autoimmune hepatitis

Chan Maung Nyein et al.

JOURNAL OF HEPATOLOGY (2022)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis or drug-induced autoimmune hepatitis following Covid-19 vaccination?

Federica Fimiano et al.

LIVER INTERNATIONAL (2022)

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Article Immunology

First report of post-transplant autoimmune hepatitis recurrence following SARS-CoV-2 mRNA vaccination

Aarani Mahalingham et al.

Summary: There have been reports of mRNA vaccines triggering autoimmune hepatitis, but there have been few reports of recurrence in liver transplant patients. We describe a case of autoimmune hepatitis patient who experienced immune-mediated flare-ups after receiving the Pfizer-BioNTech mRNA vaccine, requiring steroid treatment.

TRANSPLANT IMMUNOLOGY (2022)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis developing after COVID 19 vaccine: Presumed guilty?

Domitille Erard et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2022)

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Review Gastroenterology & Hepatology

SARS-CoV-2 infection and liver involvement

Mingjia Luo et al.

Summary: The COVID-19 pandemic has significantly affected patients with underlying liver disease, causing high morbidity and mortality. The mechanisms of liver injury in SARS-CoV-2 infection are not fully understood, but elevated liver enzymes have been identified as risk factors. This review provides an overview of the impact of COVID-19 on various liver diseases, including cirrhosis, alcohol-related liver disease, autoimmune liver disease, non-alcoholic fatty liver disease, hepatitis B and C virus infection, liver-transplant recipients, and hepatocellular carcinoma. Additionally, emerging data on vaccination in liver diseases are discussed.

HEPATOLOGY INTERNATIONAL (2022)

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Editorial Material Immunology

Autoimmune hepatitis following COVID-19 vaccination

Arantzazu Izagirre et al.

JOURNAL OF AUTOIMMUNITY (2022)

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Article Immunology

Autoimmune hepatitis after SARS-CoV-2 vaccine: New-onset or flare-up?

Enver Avci et al.

Summary: Infection with SARS-CoV-2 or vaccination against it may trigger autoimmune diseases, with autoimmune hepatitis being a potential manifestation. Clinicians should exercise caution and consider autoimmune hepatitis as a possible etiology when diagnosing patients.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Immunology

Autoimmune hepatitis after COVID-19 vaccine-more than a coincidence

Isabel Garrido et al.

Summary: The case of acute severe autoimmune hepatitis following COVID-19 vaccination highlights the importance of closely monitoring adverse reactions during the vaccination process to ensure safety. Healthcare providers must remain vigilant during mass COVID-19 vaccination to detect and manage potential complications promptly.

JOURNAL OF AUTOIMMUNITY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: Causality or casualty?

Fernando Bril et al.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Recent advances in clinical practice: epidemiology of autoimmune liver diseases

Palak J. Trivedi et al.

Summary: Autoimmune liver diseases, including primary biliary cholangitis, primary sclerosing cholangitis, and autoimmune hepatitis, show meaningful changes in disease epidemiology with increasing incidence and prevalence in Europe, North America, and the Asia-Pacific region. Global variations exist in contemporary incidence rates, with age, sex, and race impacting clinical outcomes and the need for gastroenterology, hepatology, and organ transplant services.

GUT (2021)

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Letter Medicine, General & Internal

Autoimmune hepatitis triggered by COVID-19

Jessica K. Hong et al.

INTERNAL MEDICINE JOURNAL (2021)

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Article Immunology

Acute autoimmune-like hepatitis with atypical anti-mitochondrial antibody after mRNA COVID-19 vaccination: A novel clinical entity?

Michele Ghielmetti et al.

Summary: This case report describes a 63-year-old man who developed acute severe autoimmune-like hepatitis seven days after receiving the mRNA1273 SARS-CoV-2 vaccine, despite having no history of autoimmunity or natural infection with the virus. The patient displayed unique autoimmune liver serology patterns, including an atypical anti-mitochondrial antibody (AMA) and a distinct type of anti-nuclear antibody (ANA). Treatment with prednisone was effective for this emerging condition.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Immunology

Autoimmune hepatitis triggered by SARS-CoV-2 vaccination

Elise Vuille-Lessard et al.

Summary: Autoimmune diseases have been reported to develop after SARS-CoV-2 infection, as well as following vaccination against the virus. The potential mechanisms involve molecular mimicry and bystander activation. Further investigation is needed to understand the link between SARS-CoV2 vaccination and autoimmune diseases.

JOURNAL OF AUTOIMMUNITY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis developing after the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccine

Daniel Clayton-Chubb et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

Another case of autoimmune hepatitis after SARS-CoV-2 vaccination - still casualty?

Maria-Carlota Londono et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis following COVID-19 vaccination: True causality or mere association?

Chin Kimg Tan et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis following SARS-CoV-2 vaccine: May not be a casuality

Alba Rocco et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

An unusual case of acute cholestatic hepatitis after m-RNABNT162b2 (Comirnaty) SARS-CoV-2 vaccine: Coincidence, autoimmunity or drug- related liver injury

Francesca Lodato et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

The mRNA COVID-19 vaccine - A rare trigger of autoimmune hepatitis?

Cathy McShane et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis triggered by COVID-19: A report of two cases

Gokhan Kabacam et al.

LIVER INTERNATIONAL (2021)

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Review Medicine, General & Internal

Liver injury in COVID-19: Known and unknown

Feng Zhou et al.

Summary: Liver injury induced by COVID-19 has been observed, with various potential causes, but the exact relationship remains unclear. Treatment and prognosis of liver damage in patients with COVID-19 are crucial aspects to consider.

WORLD JOURNAL OF CLINICAL CASES (2021)

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Review Pathology

Pathology of autoimmune hepatitis

Claudia Covelli et al.

Summary: Autoimmune hepatitis is a relatively rare chronic liver disease that mainly affects women, characterized by hypergammaglobulinemia, circulating autoantibodies, and hepatitis in liver histology. Prompt diagnosis is crucial as untreated AIH has a high mortality rate.

PATHOLOGICA (2021)

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Article Immunology

Impact of genetic and environmental factors on autoimmune hepatitis

Kalliopi Zachou et al.

Summary: Autoimmune hepatitis is a chronic liver disease characterized by hypergammaglobulinemia, autoantibodies, and genetic predisposition, with epigenetic modifications potentially playing a crucial role in its pathogenesis.

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY (2021)

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Article Gastroenterology & Hepatology

The association between juvenile autoimmune hepatitis and HLA-DRB1 alleles: Iraqi tertiary center experience

Mohammad Fadhil Ibraheem et al.

Summary: This study aimed to investigate the impact of human leukocyte antigen (HLA) allele on susceptibility and prevention of autoimmune hepatitis (AIH) in Iraqi children. The results showed that HLA-DRB1*13, DRB1*04, and DRB1*03 are susceptibility alleles for AIH type 1, while HLA-DRB1*13, HLA-DRB4, and DRB5 are susceptibility alleles for AIH type 2 in this population. Genetic factors play a significant role in the development of autoimmune hepatitis in Iraqi children.

CLINICAL AND EXPERIMENTAL HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology