Biomarkers for Hepatocellular Carcinoma: From Origin to Clinical Diagnosis

Article Oncology

Baseline Interleukin-6 and-8 predict response and survival in patients with advanced hepatocellular carcinoma treated with sorafenib monotherapy: an exploratory post hoc analysis of the SORAMIC trial

Osman Oecal et al.

Summary: Baseline IL-6 and IL-8 values were found to predict outcomes in sorafenib-treated HCC patients, suggesting potential for guiding patient selection and improving treatment outcomes.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022)

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Article Gastroenterology & Hepatology

m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma

Chengcheng Tong et al.

Summary: This study systematically investigated the modification patterns of N1-methyladenosine (m1A) in hepatocellular carcinoma (HCC) samples and evaluated their metabolic characteristics. Three distinct m1A modification patterns were identified, and a scoring system called m1Ascore was developed. The m1Ascore showed clinical value in risk stratification and drug screening. The study provides insights into m1A modification and metabolic heterogeneity in cancer, leading to improved risk stratification and individualized treatment strategies.

BMC GASTROENTEROLOGY (2022)

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Article Biochemistry & Molecular Biology

Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma

Tsuyoshi Suda et al.

Summary: This study evaluated the potential of serum DKK-1 as a diagnostic and prognostic marker for hepatocellular carcinoma (HCC). The results showed that DKK-1 levels were significantly elevated in HCC patients and high levels were associated with poor prognosis. The study also demonstrated that anti-DKK-1 antibody treatment inhibited tumor growth, while recombinant DKK-1 promoted cell proliferation, invasion, and angiogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

Osteopontin promotes hepatocellular carcinoma progression through inducing JAK2/STAT3/NOX1-mediated ROS production

Qipeng Wu et al.

Summary: This study demonstrates that osteopontin (OPN) promotes hepatocellular carcinoma (HCC) progression by increasing reactive oxygen species (ROS) production through upregulating the expression of NADPH oxidase 1 (NOX1) and activating the JAK2/STAT3 signaling pathway. Disruption of the OPN/NOX1 axis might be a promising therapeutic strategy for HCC.

CELL DEATH & DISEASE (2022)

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Review Oncology

Current Imaging Diagnosis of Hepatocellular Carcinoma

Evangelos Chartampilas et al.

Summary: The role of imaging in the management of hepatocellular carcinoma (HCC) has evolved significantly, providing earlier diagnosis, accurate characterization, and evaluation of treatment response. Various imaging modalities and techniques, including liver specific contrast agents and perfusion techniques, are incorporated into the diagnostic protocols for HCC.

CANCERS (2022)

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Review Biochemistry & Molecular Biology

N1-methyladenosine modification in cancer biology: Current status and future perspectives

Jiexin Li et al.

Summary: Post-transcriptional modifications, such as m1A modification, play a crucial role in regulating the behavior and function of RNAs. m1A modification, regulated by writers, erasers, and readers, is reversible and found in various types of RNA. It affects RNA processing, structure, and function, and has been shown to be involved in tumorigenesis.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

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Review Gastroenterology & Hepatology

Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma

Joseph C. Ahn et al.

Summary: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide, and current tests like alpha-fetoprotein have limited accuracy. Liver biopsy, while informative, is not routinely used due to invasiveness, leading to a need for new biomarkers. Liquid biopsy, specifically detection of circulating tumor cells (CTCs), offers potential for early detection and personalized treatment management in HCC patients. Quantitative analysis of CTCs can predict disease prognosis and treatment response, highlighting the importance of developing CTC detection platforms for clinical use.

HEPATOLOGY (2021)

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Article Medical Laboratory Technology

Toll-like receptor 7 mRNA is reduced in hepatitis C-based liver cirrhosis and hepatocellular carcinoma, out-performs alpha-fetoprotein levels, and with age and serum aspartate aminotransferase is a new diagnostic index

A. A. Mohamed et al.

Summary: TLR-7 mRNA levels perform better than AFP in HCC diagnosis, and the combination of age and AST can improve the performance of TLR-7, predicting early HCC. The index score derived from age, AST, and TLR-7 mRNA is superior in predicting HCC and correlated with certain liver cancer staging systems.

BRITISH JOURNAL OF BIOMEDICAL SCIENCE (2021)

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Article

Serum Golgi protein 73 as a sensitive biomarker for early detection of hepatocellular carcinoma among Egyptian patients with hepatitis C virus-related cirrhosis

Mohamed Eissa et al.

Medical Journal Armed Forces India (2021)

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Article Medical Laboratory Technology

HCC-Mark: a simple non-invasive model based on routine parameters for predicting hepatitis C virus related hepatocellular carcinoma

M. Omar et al.

Summary: The HCC-Mark model developed in this study accurately predicts hepatocellular carcinoma and its clinical features, outperforming other non-invasive models.

BRITISH JOURNAL OF BIOMEDICAL SCIENCE (2021)

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Review Biochemistry & Molecular Biology

The dark-side of the outside: how extracellular heat shock proteins promote cancer

Laura Secli et al.

Summary: Heat shock proteins play crucial roles in cellular homeostasis and stress response, with extracellular heat shock proteins potentially contributing to cancer development and metastasis by supporting cancer hallmarks and modulating the tumor microenvironment.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Oncology

The Role of Liquid Biopsy in Hepatocellular Carcinoma Prognostication

Ismail Labgaa et al.

Summary: Liquid biopsy offers a minimally invasive way to access DNA, RNA, exosomes, and cells circulating in the bloodstream, showing promising potential for improving hepatocellular carcinoma (HCC) prognostication. It may prove to be a valuable tool in refining prognostic systems for HCC by analyzing molecular readouts from solid tumors released into biological fluids.

CANCERS (2021)

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Article Oncology

α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study

Shi-Xun Lu et al.

Summary: The study demonstrates that AFP mRNA detected by RNAscope can increase the sensitivity in detecting HCC, and in combination with GPC3, can better differentiate HCC from benign/non-hepatocytic lesions.

BRITISH JOURNAL OF CANCER (2021)

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Review Oncology

Unique situation of hepatocellular carcinoma in Egypt: A review of epidemiology and control measures

Reem Ezzat et al.

Summary: Hepatocellular carcinoma is a significant public health issue in Egypt, where a mass screening program for detecting and treating HCV has led to increased detection rates. A multidisciplinary approach to HCC management is widely applied, and various treatment modalities with success rates comparable to global levels are available in Egypt. The Egyptian health authorities have prioritized the elimination of HCV, which is expected to decrease the number of HCC cases in the near future.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Review Gastroenterology & Hepatology

Hepatocellular carcinoma in viral and autoimmune liver diseases: Role of CD4+CD25+Foxp3+regulatory T cells in the immune microenvironment

Alessandro Granito et al.

Summary: Over 90% of hepatocellular carcinoma cases occur in patients with cirrhosis, with hepatitis B virus and hepatitis C virus as leading causes. Immunotherapy has revolutionized HCC treatment by targeting immune cells rather than cancer cells, particularly focusing on regulatory T cells for their role in tumor progression and response to immune checkpoint inhibitors.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Article Oncology

Expression Status and Prognostic Significance of Gamma-Glutamyl Transpeptidase Family Genes in Hepatocellular Carcinoma

Shan Tian et al.

Summary: This study found differential expression of GGT family members in primary HCC samples and normal control tissues, with GGT1, GGT5, and GGT7 being correlated with overall survival in HCC patients. GGT family genes were also associated with immune cell infiltration levels in HCC, particularly CD4+ T cells, macrophages, and dendritic cells. Additionally, high serum GGT protein expression was identified as a strong prognostic factor for unfavorable overall survival in HCC patients undergoing curative hepatectomy.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Development of a Toll-Like Receptor-Based Gene Signature That Can Predict Prognosis, Tumor Microenvironment, and Chemotherapy Response for Hepatocellular Carcinoma

Lixia Liu et al.

Summary: The study identified 60 HCC-specific TLRs and established a TLR-based gene signature for prognosis evaluation. High-risk patients had unfavorable outcomes and showed higher sensitivity to gemcitabine and cisplatin, suggesting potential personalized therapy options for HCC patients.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Medicine, General & Internal

The Applicability of ADA, AFU, and LAC in the Early Diagnosis and Disease Risk Assessment of Hepatitis B-Associated Liver Cirrhosis and Hepatocellular Carcinoma

Wei Zhang et al.

Summary: This study found that ADA, AFU, and LAC have good value in the early diagnosis of chronic hepatitis B, liver cirrhosis, and hepatocellular carcinoma, and their combined detection is more effective than single detection. These three indicators can serve as risk predictors of liver cirrhosis, while AFU and LAC can be considered early risk predictors of hepatocellular carcinoma.

FRONTIERS IN MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

A novel model based on interleukin 6 and insulin-like growth factor II for detection of hepatocellular carcinoma associated with hepatitis C virus

Mohamed M. Omran et al.

Summary: The study compared the performance of IL-6 and IGF 2 with AFP in the early detection of HCC. Results showed that IGF2 and IL6 performed better in discriminating HCC from liver cirrhosis, and a model with four markers was proposed with high discriminatory ability. For small tumors and early-stage HCC, the model showed excellent performance.

JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA-based signature for predicting prognosis of hepatocellular carcinoma

Jie Cao et al.

Summary: This study established a 19-lncRNA signature to predict the prognosis of hepatocellular carcinoma (HCC) patients. The signature, combined with clinicopathologic factors, showed high predictive performance and may play a crucial role in guiding the management of HCC.

BIOENGINEERED (2021)

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Article Gastroenterology & Hepatology

A combination of α-fetoprotein, midkine, thioredoxin and a metabolite for predicting hepatocellular carcinoma

Mohamed M. Omran et al.

ANNALS OF HEPATOLOGY (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Current role of ultrasound in the diagnosis of hepatocellular carcinoma

Hironori Tanaka

JOURNAL OF MEDICAL ULTRASONICS (2020)

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Review Cell Biology

Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases

Eline Geervliet et al.

CELLS (2020)

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Review Biochemistry & Molecular Biology

Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives

Abdullah Hoter et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Article

The diagnostic value of golgi protien-73 and DICKKOPF-1 in hepatocellular carcinoma

Wafaa Mohammed ElZefzafy et al.

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY (2020)

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Review Oncology

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

Tiziana Annese et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Medicine, Research & Experimental

Circulating tumor cells in hepatocellular carcinoma: single -cell based analysis, preclinical models, and clinical applications

Qian Zhang et al.

THERANOSTICS (2020)

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Review Biochemistry & Molecular Biology

Advances in the early diagnosis of hepatocellular carcinoma

Weiyi Wang et al.

GENES & DISEASES (2020)

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Review Oncology

Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview

Wafaa M. Rashed et al.

JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE (2020)

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Article Oncology

May Neutrophil Gelatinase-Associated Lipocalin (NGAL) Level Predict Mortality in Patients with Hepatocellular Carcinoma (HCC)?

Ramazan Dertli et al.

JOURNAL OF GASTROINTESTINAL CANCER (2020)

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Article Biochemistry & Molecular Biology

Serum MicroRNAs as Biomarkers in Hepatitis C: Preliminary Evidence of a MicroRNA Panel for the Diagnosis of Hepatocellular Carcinoma

Anna Weis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Gastroenterology & Hepatology

Identification of plasma miR-148a as a noninvasive biomarker for hepatocellular carcinoma

Juqiang Han et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2019)

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Review Biochemistry & Molecular Biology

Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA

Qianwei Ye et al.

MOLECULAR CANCER (2019)

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Review Biochemistry & Molecular Biology

Immunomodulatory TGF-β Signaling in Hepatocellular Carcinoma

Jian Chen et al.

TRENDS IN MOLECULAR MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Circulating microRNA-301 as a promising diagnostic biomarker of hepatitis C virus-related hepatocellular carcinoma

Moamena S. El-Hamouly et al.

MOLECULAR BIOLOGY REPORTS (2019)

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Review Gastroenterology & Hepatology

Role of liver biopsy in hepatocellular carcinoma

Luca Di Tommaso et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Review Oncology

The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma

Cristian Scheau et al.

ANALYTICAL CELLULAR PATHOLOGY (2019)

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Article Multidisciplinary Sciences

Evaluation of AGP Fucosylation as a Marker for Hepatocellular Carcinoma of Three Different Etiologies

Jing Liang et al.

SCIENTIFIC REPORTS (2019)

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Review Gastroenterology & Hepatology

A systematic review and meta-analysis of evaluation of serum interleukin 8 levels in hepatocellular carcinoma

Ebrahim Shakiba et al.

CLINICAL AND EXPERIMENTAL HEPATOLOGY (2019)

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Review Chemistry, Medicinal

Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment

Fubo Zhou et al.

MEDICINAL RESEARCH REVIEWS (2018)

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Article Gastroenterology & Hepatology

Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

Jorge A. Marrero et al.

HEPATOLOGY (2018)

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Review Biochemistry & Molecular Biology

Insulin-Like Growth Factor (IGF) System in Liver Diseases

Agnieszka Adamek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Gastroenterology & Hepatology

Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: a retrospective cohort study

Patricia dos Santos Marcon et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Review Oncology

Revisiting Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Cancer: Saint or Sinner?

Brigitte Bauvois et al.

CANCERS (2018)

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Article Oncology

Epidemiology of liver cancer in Nile delta over a decade: A single-center study

Sherief Abd-Elsalam et al.

SOUTH ASIAN JOURNAL OF CANCER (2018)

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Article Gastroenterology & Hepatology

Optimizing the Diagnostic Role of Alpha-Fetoprotein and Abdominal Ultrasound by Adding Overexpressed Blood mRNA Matrix Metalloproteinase-12 for Diagnosis of HCV-Related Hepatocellular Carcinoma

Esam Elshimi et al.

GASTROINTESTINAL TUMORS (2018)

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Article Oncology

Simplified HCC-ART score for highly sensitive detection of small-sized and early-stage hepatocellular carcinoma in the widely used Okuda, CLIP, and BCLC staging systems

Abdelfattah M. Attallah et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Medicine, General & Internal

Usefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma

Sang Joon Park et al.

MEDICINE (2017)

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Article Medical Laboratory Technology

The diagnosis and treatment of hepatocellular carcinoma

Justin Hartke et al.

SEMINARS IN DIAGNOSTIC PATHOLOGY (2017)

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Article Gastroenterology & Hepatology

Diagnostic accuracy of osteopontin plus alpha-fetoprotein in the hepatocellular carcinoma: A meta-analysis

Jinwan Li et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2017)

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Article Multidisciplinary Sciences

Serum fibronectin distinguishes the early stages of hepatocellular carcinoma

Hyunsoo Kim et al.

SCIENTIFIC REPORTS (2017)

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Article Biotechnology & Applied Microbiology

The Diagnostic Roles of Cytokines in Hepatobiliary cancers

Yavuz Savas Koca et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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Review Oncology

Osteopontin -- a promising biomarker for cancer therapy

Ran Wei et al.

JOURNAL OF CANCER (2017)

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Article Medical Laboratory Technology

The Value of GPC3 and GP73 in Clinical Diagnosis of Hepatocellular Carcinoma

Ji-Sheng Jing et al.

CLINICAL LABORATORY (2017)

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Article Medical Laboratory Technology

Combined use of nuclear phosphoprotein c-Myc and cellular phosphoprotein p53 for hepatocellular carcinoma detection in high-risk chronic hepatitis C patients

A. M. Attallah et al.

BRITISH JOURNAL OF BIOMEDICAL SCIENCE (2017)

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Article Gastroenterology & Hepatology

The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma

Shogo Kobayashi et al.

GASTROINTESTINAL TUMORS (2017)

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Review Medicine, General & Internal

Hepatitis C in Egypt - past, present, and future

Ahmed Elgharably et al.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2017)

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Review Biochemistry & Molecular Biology

Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy

Saverio Candido et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

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Review Gastroenterology & Hepatology

Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region

Ran Xu Zhu et al.

GUT AND LIVER (2016)

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Article Multidisciplinary Sciences

Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma

Roslyn Vongsuvanh et al.

PLOS ONE (2016)

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Article Medicine, Research & Experimental

Biomarkers: evaluation of clinical utility in surveillance and early diagnosis for hepatocellular carcinoma

Peipei Song et al.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2016)

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Article Gastroenterology & Hepatology

Clinical significance and diagnostic value of serum dickkopf-1 in patients with hepatocellular carcinoma

Yasser M. Fouad et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2016)

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Article Oncology

GPC-HCC model: a combination of glybican-3 with other routine parameters improves the diagnostic efficacy in hepatocellular carcinoma

Abdelfattah M. Attallah et al.

TUMOR BIOLOGY (2016)

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Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

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Article Multidisciplinary Sciences

Diagnostic Performance of Alpha-Fetoprotein, Protein Induced by Vitamin K Absence, Osteopontin, Dickkopf-1 and Its Combinations for Hepatocellular Carcinoma

Eun Sun Jang et al.

PLOS ONE (2016)

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Review Gastroenterology & Hepatology

Hepatocellular carcinoma: Review of disease and tumor biomarkers

Jin Un Kim et al.

WORLD JOURNAL OF HEPATOLOGY (2016)

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Review Oncology

GPC-3 in hepatocellular carcinoma: current perspectives

Yongle Wu et al.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2016)

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Article Gastroenterology & Hepatology

A simple diagnostic index comprising epithelial membrane antigen and fibronectin for hepatocellular carcinoma

Abdelfattah M. Attallah et al.

ANNALS OF HEPATOLOGY (2015)

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Article

Predictive Value of Serum Insulin-like Growth Factor-1 in Hepatocellular Carcinoma

Nehal Elmashad et al.

Asian Pacific Journal of Cancer Prevention (2015)

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Review Medical Laboratory Technology

Prognostic value of cytokeratin 19 in hepatocellular carcinoma: A meta-analysis

Da-wei Sun et al.

CLINICA CHIMICA ACTA (2015)

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Review Medical Laboratory Technology

Squamous cell carcinoma antigen in hepatocellular carcinoma: Ready for the prime time?

Martina Montagnana et al.

CLINICA CHIMICA ACTA (2015)

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Article Gastroenterology & Hepatology

Plasma Osteopontin Level in Chronic Liver Disease and Hepatocellular Carcinoma

Shawky Abdelhamid Fouad et al.

HEPATITIS MONTHLY (2015)

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Article

An Easy and Useful Noninvasive Score Based on α-1-acid Glycoprotein and C-Reactive Protein for Diagnosis of Patients with Hepatocellular Carcinoma Associated with Hepatitis C Virus Infection

Mohamed M. Omran et al.

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY (2015)

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Article Oncology

HCC-DETECT: a combination of nuclear, cytoplasmic, and oncofetal proteins as biomarkers for hepatocellular carcinoma

Abdelfattah M. Attallah et al.

TUMOR BIOLOGY (2015)

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Article Gastroenterology & Hepatology

Biomarkers for the early diagnosis of hepatocellular carcinoma

Nobuhiro Tsuchiya et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

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Article Oncology

Serum thioredoxin is a diagnostic marker for hepatocellular carcinoma

Jun Li et al.

ONCOTARGET (2015)

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Review Oncology

The macro world of microRNAs in hepatocellular carcinoma

Kaveri Sidhu et al.

FRONTIERS IN ONCOLOGY (2015)

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Review Medicine, Research & Experimental

Diagnosis Accuracy of Serum Glypican-3 in Patients with Hepatocellular Carcinoma: A Systematic Review with Meta-analysis

Xiaobo Jia et al.

ARCHIVES OF MEDICAL RESEARCH (2014)

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Review Medicine, Research & Experimental

Role of estrogen in hepatocellular carcinoma: is inflammation the key?

Liang Shi et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

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Article Gastroenterology & Hepatology

Impact of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance on the non-invasive diagnosis of small hepatocellular carcinoma: a prospective study

A. Granito et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2013)

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Article Oncology

HCC-ART score, a simple, highly sensitive and specific test for early diagnosis of hepatocellular carcinoma: a large-scale, multicentre study

A. M. Attallah et al.

BRITISH JOURNAL OF CANCER (2013)

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Article Oncology

Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma

Yulin Sun et al.

CARCINOGENESIS (2013)

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Article Gastroenterology & Hepatology

Novel des--carboxy prothrombin in serum for the diagnosis of hepatocellular carcinoma

Takahiro Tanaka et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)

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Article Gastroenterology & Hepatology

Identification of osteopontin as a novel marker for early hepatocellular carcinoma

Sufen Shang et al.

HEPATOLOGY (2012)

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Article Gastroenterology & Hepatology

Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma

Yoshito Tomimaru et al.

JOURNAL OF HEPATOLOGY (2012)

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Article Medicine, General & Internal

Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma: a retrospective cohort study

Angela M. Liu et al.

BMJ OPEN (2012)

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Review Gastroenterology & Hepatology

Biomarkers for Hepatocellular Carcinoma

Tara Behne et al.

INTERNATIONAL JOURNAL OF HEPATOLOGY (2012)

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Article Medical Laboratory Technology

Evaluation of cytokeratin-1 in the diagnosis of hepatocellular carcinoma

Abdelfattah M. Attallah et al.

CLINICA CHIMICA ACTA (2011)

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Article Gastroenterology & Hepatology

The Global Epidemiology of Hepatocellular Carcinoma: Present and Future

Katherine A. McGlynn et al.

CLINICS IN LIVER DISEASE (2011)

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Article Biology

MicroRNA functional network in pancreatic cancer: From biology to biomarkers of disease

Jin Wang et al.

JOURNAL OF BIOSCIENCES (2011)

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Article Oncology

Plasma MicroRNA Panel to Diagnose Hepatitis B Virus-Related Hepatocellular Carcinoma

Jian Zhou et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

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Article Gastroenterology & Hepatology

Des-γ-Carboxy Prothrombin and α-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma

Anna S. Lok et al.

GASTROENTEROLOGY (2010)

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Article Gastroenterology & Hepatology

Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma

Yilei Mao et al.

GUT (2010)

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Article Oncology

Serum protein biomarkers screening in HCC patients with liver cirrhosis by ICAT-LC-MS/MS

Xiaonan Kang et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)

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Article Oncology

Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis

S. J. Schoenleber et al.

BRITISH JOURNAL OF CANCER (2009)

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Review Oncology

Vascular Endothelial Growth Factor in the Management of Hepatocellular Carcinoma A Review of Literature

Ahmed O. Kaseb et al.

CANCER (2009)

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Article Medical Laboratory Technology

Combination of alpha-1-acid glycoprotein and alpha-fetoprotein as an improved diagnostic tool for hepatocellular carcinoma

Indra Bachtiar et al.

CLINICA CHIMICA ACTA (2009)

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Editorial Material Gastroenterology & Hepatology

Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer

Michael Hoepfner et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

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Article Biochemistry & Molecular Biology

Hepatocyte growth factor, transforming growth factor α, and their receptors as combined markers of prognosis in hepatocellular carcinoma

M Daveau et al.

MOLECULAR CARCINOGENESIS (2003)

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Biomarkers for Hepatocellular Carcinoma: From Origin to Clinical Diagnosis

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