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Microbiome Alterations and Alzheimer's Disease: Modeling Strategies with Transgenic Mice

BIOMEDICINES (2023)

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Article Multidisciplinary Sciences

ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

Dong-oh Seo et al.

SCIENCE (2023)

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Article Nutrition & Dietetics

Gamma-Aminobutyric Acid Promotes Beige Adipocyte Reconstruction by Modulating the Gut Microbiota in Obese Mice

Xiaoyi Ma et al.

Summary: This study found that gamma-aminobutyric acid (GABA) promotes the beiging process of inguinal white adipose tissue (iWAT) by improving the gut microbiota composition, thereby reducing obesity. Specifically, GABA reduced body weight and adipose inflammation and promoted the expression of thermogenic genes in the iWAT. Moreover, GABA altered the gut microbiota composition and metabolite levels in obese mice. The findings suggest that GABA may promote iWAT beiging through the gut microbiota, protecting obese individuals against metabolic abnormalities caused by obesity and gut dysbiosis.

NUTRIENTS (2023)

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Review Microbiology

Butyrate producers, The Sentinel of Gut: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

Vineet Singh et al.

Summary: Gut-microbial butyrate, a short-chain fatty acid, has significant physiological importance. Butyrate producers, belonging to the Clostridium cluster, metabolize carbohydrates to produce butyrate. They play a vital role in various gut-associated metabolisms.

FRONTIERS IN MICROBIOLOGY (2023)

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Review Cell Biology

Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Chiara Mazziotta et al.

Summary: Immune cells and commensal microbes in the human intestine communicate and react with each other to maintain healthy immune activities. Probiotic bacteria can stimulate immune cells and microflora to modulate immune functions and homeostasis. The use of probiotics has potential for improving immune system activities.

CELLS (2023)

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Review Biochemistry & Molecular Biology

Influence of the Mediterranean Diet on Healthy Aging

Maria Carmen Andreo-Lopez et al.

Summary: The global population's life expectancy has increased, leading to challenges in an aging population. Aging is influenced by molecular mechanisms and the gut microbiota, which is affected by factors such as diet. The Mediterranean diet and its components provide evidence of its impact on healthy aging. This review analyzes the influence of the Mediterranean diet on molecular pathways and the microbiota associated with favorable aging patterns, as well as its potential as an anti-aging treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Immunology

IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer's disease

Rachel Pei-Hsuan Wang et al.

Summary: This study demonstrates that systemic inflammation caused by periodontitis contributes to the development of Alzheimer's disease and leads to cognitive decline.

JOURNAL OF NEUROINFLAMMATION (2023)

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Review Neurosciences

Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy

Naruhiko Sahara et al.

Summary: Neurofibrillary tangles composed of hyperphosphorylated tau protein are key features of tauopathy. However, there is a limited number of animal models that display intracellular tau pathology. Recent studies have shown that transgenic mice expressing mutant tau successfully develop neurofibrillary pathology, but there are limitations and pitfalls to be addressed.

FRONTIERS IN NEUROSCIENCE (2023)

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Review Cell Biology

Mechanisms of Blood-Brain Barrier Protection by Microbiota-Derived Short-Chain Fatty Acids

Ekaterina Fock et al.

Summary: Short-chain fatty acids (SCFAs), such as acetate, butyrate and propionate, decrease the paracellular permeability and improve the compromised blood-brain barrier (BBB) by influencing the transcription, cellular localization and proteolytic degradation of junctional complex proteins. The mainstream mechanisms of SCFAs' effect on the preservation of BBB integrity involve G-protein-coupled receptor-mediated effects, SCFAs-stimulated acetylation of histone and non-histone proteins via inhibition of histone deacetylases, and crosstalk with transcriptional factors NF-kappa B and Nrf2.

CELLS (2023)

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Review Cell Biology

Towards early detection of neurodegenerative diseases: A gut feeling

Stephanie Makdissi et al.

Summary: The gut-brain axis facilitates communication between the gastrointestinal tract and the nervous system through various connections. Alterations in this axis are becoming recognized as a contributing factor to neuroinflammation, which is involved in the development of neurodegenerative diseases. Changes in diet, the microbiota, and intestinal epithelial functions have been found to influence the inflammatory state of neurons and contribute to the onset and progression of these diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)

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Article Cell Biology

Gut microbiota in patients with Alzheimer’s disease spectrum: a systematic review and meta-analysis

Chun-Che Hung et al.

Aging-US (2022)

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Review Medicine, Research & Experimental

The Gut-Brain Axis

Emeran A. Mayer et al.

Summary: Preclinical evidence has shown bidirectional interactions among the brain, gut, and gut microbiome, with candidate signaling molecules and three communication channels. Alterations in gut-brain-microbiome interactions have been found in various disorders, but the causative role of the microbiome in irritable bowel syndrome is still unclear. Current therapies are limited to dietary interventions and targeted pharmacological and behavioral approaches. Further research and randomized controlled trials are needed for effective therapies.

ANNUAL REVIEW OF MEDICINE (2022)

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Review Cell Biology

Dysbiosis and Alzheimer's Disease: Cause or Treatment Opportunity?

Manuel H. Janeiro et al.

Summary: Recent studies have shown increased interest in the relationship between gut microbiota and human health, with dysbiosis potentially leading to diseases such as obesity, diabetes, and neurological disorders like Alzheimer's disease. The gut-brain axis involves communication pathways between the brain and gut, including the autonomic, neuroendocrine, and immune systems, as well as bacterial metabolites and neuromodulatory molecules. This pathway allows microbiota to influence the onset and progression of neuropathologies like AD through effects on neuroinflammation, cerebrovascular degeneration, and Aβ clearance.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals' Health and Disease

Piotr Konopelski et al.

Summary: This review investigates the biological actions of indole-3-propionic acid (IPA), a gut microbiota-derived metabolite of tryptophan. IPA exhibits similar effects as its precursor, tryptophan, on energetic balance and the cardiovascular system. It also has positive impacts on a cellular level by preventing oxidative stress and inflammation. Factors such as risk factors of atherosclerosis decrease IPA synthesis, while protective factors like the Mediterranean diet tend to increase its concentration. IPA shows promise as a new target linking gut health with the cardiovascular system.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cell Biology

The role of trimethylamine-N-Oxide in the development of Alzheimer's disease

Nida Buawangpong et al.

Summary: TMAO, a gut microbiota metabolite derived from dietary choline and carnitine, has been identified as a potential risk factor of Alzheimer's disease. Through various pathophysiological pathways, TMAO is associated with Alzheimer's disease by causing protein aggregation and activating astrocytes.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Editorial Material Microbiology

Science depends on nomenclature, but nomenclature is not science

Karen G. Lloyd et al.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Nutrition & Dietetics

The Potential Role of Gut Microbiota in Alzheimer's Disease: From Diagnosis to Treatment

Angelica Varesi et al.

Summary: The dysregulation of gut microbiota is implicated in various diseases, including Alzheimer's Disease (AD). This article reviews the role of gut microbiota in brain health and disease and presents evidence for its dysregulation in AD patients. It discusses the potential of using dysbiosis as a diagnostic tool and explores the therapeutic interventions using prebiotics, probiotics, fecal microbiota transplantation, and diets in AD.

NUTRIENTS (2022)

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Review Clinical Neurology

Animal and Cellular Models of Alzheimer's Disease: Progress, Promise, and Future Approaches

Laura Trujillo-Estrada et al.

Summary: Alzheimer's disease is an incurable neurodegenerative disease affecting over 45 million people worldwide, with transgenic mouse models playing a significant role in elucidating its pathogenic mechanisms. However, limitations of current animal models highlight the need for more reliable models and human cellular models to improve the success rate of translating preclinical therapies into human treatments.

NEUROSCIENTIST (2022)

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Review Nutrition & Dietetics

Alzheimer's disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role?

Pablo Arrona Cardoza et al.

Summary: Alzheimer's disease is a neurodegenerative disease that affects memory and cognitive function. Gut microbiota and dietary factors may play a role in its development. Consumption of a Western-type diet may increase the risk of AD through microbiota-produced TMAO.

NUTRITION REVIEWS (2022)

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Article Clinical Neurology

Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial

Siobhan Hoscheidt et al.

Summary: The study revealed that dietary patterns in mid-life are associated with Alzheimer's disease risk, and individuals with different cognitive statuses respond differently to different diets.

ALZHEIMERS & DEMENTIA (2022)

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Review Cell Biology

The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer's disease: A narrative review

Emma Aaldijk et al.

Summary: This review summarizes the available evidence concerning the orchestrating role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer's disease (AD), and highlights general considerations for future studies.

AGEING RESEARCH REVIEWS (2022)

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Review Biochemistry & Molecular Biology

Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis

Raquel Sanchez-Varo et al.

Summary: This review provides an overview of the major pathological elements of Alzheimer's disease and discusses the insights provided by mouse models in understanding the underlying mechanisms. It highlights the pros and cons of current models and explores the potential benefits of combining transgenic mice with omics technologies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Nutrition & Dietetics

Multiple roles of short-chain fatty acids in Alzheimer disease

Hui Chen et al.

Summary: The study highlights the significant roles of short-chain fatty acids (SCFAs) in the pathogenesis of Alzheimer's disease (AD) through epigenetic regulation, modulation of neuroinflammation, maintenance of the blood-brain barrier (BBB), regulation of brain metabolism, and interference in amyloid protein formation. Specifically, butyrate plays a key role in interfering with the development of AD, while the effects of other SCFAs like propionate may vary in different pathways, indicating the complexity of their role in AD pathogenesis.

NUTRITION (2022)

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Review Clinical Neurology

Mediterranean diet adherence, gut microbiota, and Alzheimer's or Parkinson's disease risk: A systematic review

Rebecca J. Solch et al.

Summary: The Mediterranean diet may reduce the risk of Alzheimer's disease and Parkinson's disease by modulating the gut microbiota. Existing studies have shown an association between adherence to the Mediterranean diet and a lower risk of developing these neurodegenerative diseases, but more research is needed to establish a causal relationship.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2022)

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Review Microbiology

Polymicrobial Interactions of Oral Microbiota: a Historical Review and Current Perspective

Mengshi Zhang et al.

Summary: The diversity and importance of the oral microbiome play a vital role in oral and overall health, and studying oral diseases can provide insights into the complexity and dynamics of polymicrobial interactions.

MBIO (2022)

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Article Nutrition & Dietetics

Intestinal Dysbiosis in Patients with Histamine Intolerance

Sonia Sanchez-Perez et al.

Summary: Diamine oxidase (DAO) deficiency is an underlying cause of histamine intolerance. It can originate from genetic, pharmacological, or pathological factors, and may also be linked to alterations in the gut microbiota. A study found dysbiosis of the gut microbiota in patients with histamine intolerance, with lower levels of certain bacteria related to gut health and higher levels of histamine-secreting bacteria. This imbalance could lead to the accumulation of histamine in the gut and subsequent adverse effects.

NUTRIENTS (2022)

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Review Neurosciences

Recent Advances in the Modeling of Alzheimer's Disease

Hiroki Sasaguri et al.

Summary: This article introduces transgenic mouse models of Alzheimer's disease (AD) and discusses their limitations and applications. The first generation models have artificial phenotypes, while the second generation models have specific strengths and weaknesses. The third generation models exhibit more pathology and are suitable for preclinical studies. The article also provides a technical guide for using App knock-in mice in AD research and discusses the latest advances in using human tau knock-in mice and non-human primate models of AD.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Neurosciences

The Impact of Probiotic Supplementation on Cognitive, Pathological and Metabolic Markers in a Transgenic Mouse Model of Alzheimer's Disease

Thomas S. Webberley et al.

Summary: Supplementation with Lab4b probiotic consortium may have positive effects on the cognitive and pathological progression of Alzheimer's disease, as well as improving metabolic status.

FRONTIERS IN NEUROSCIENCE (2022)

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Review Dentistry, Oral Surgery & Medicine

Association of periodontitis and oral microbiomes with Alzheimer's disease: A narrative systematic review

Samantha Mao et al.

Summary: This review explores the relationship between the oral microbiome and the development of Alzheimer's disease (AD). Previous studies have provided insufficient evidence for the association between periodontal disease and AD. However, epidemiological and post-mortem studies suggest that periodontitis may be associated with cognitive decline. The results of microbiome studies are inconsistent, but Gram-negative species may be potential pathogens. Additional large-scale studies are needed to clarify the relationship between periodontal disease and AD.

JOURNAL OF DENTAL SCIENCES (2022)

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Article Multidisciplinary Sciences

Akkermansia muciniphila phospholipid induces homeostatic immune responses

Munhyung Bae et al.

Summary: This study identifies a lipid molecule from Akkermansia muciniphila's cell membrane that exhibits immunomodulatory activity through the Toll-like receptor TLR2-TLR1 pathway. The findings provide molecular insights into the role of Akkermansia muciniphila in regulating immune balance and its impact on health and disease.

NATURE (2022)

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Review Nutrition & Dietetics

Overlapping Mechanisms of Action of Brain-Active Bacteria and Bacterial Metabolites in the Pathogenesis of Common Brain Diseases

Tanja Patricia Eicher et al.

Summary: This article discusses the impact of the microbiota-gut-brain axis on the pathophysiology of seven brain-related diseases, highlighting changes in bacterial abundance and the metabolic implications, and indicating that all seven diseases are associated with a leaky gut, neuroinflammation, and over-activated microglial cells.

NUTRIENTS (2022)

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Review Immunology

Akkermansia muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease, Obesity, and Diabetes

Vanessa Fernandes Rodrigues et al.

Summary: A. muciniphila is a beneficial bacterium that colonizes the intestinal mucosa and shows potential as an immunomodulatory probiotic for autoimmune and chronic inflammatory diseases. It has been found to slow down the development and progression of diseases such as diabetes, obesity, and IBD in mice.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases

Knut Hestad et al.

Summary: This article reviews the relationship between tryptophan metabolism, neuroinflammation, depression, and neurodegeneration, highlighting the potential role of the kynurenine pathway in the pathogenesis of neurological disorders. Increased levels of quinolinic acid, an N-methyl-D-aspartate receptor agonist, are associated with elevated inflammatory cytokines and have been observed in mood disorders and various neurodegenerative diseases.

BIOMOLECULES (2022)

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Review Geriatrics & Gerontology

Interaction between autophagy and the NLRP3 inflammasome in Alzheimer's and Parkinson's disease

Ranran Lu et al.

Summary: Autophagy is crucial for maintaining cellular homeostasis by degrading damaged organelles, misfolded proteins, and pathogens. Autophagy has a complex interaction with neuroinflammation. Strengthening autophagy can reduce neuroinflammation and protect neurons. Clearance of protein aggregates through autophagy activation can delay the progression of neurodegenerative diseases.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Genetics & Heredity

Gut Microbiome and Mycobiome Alterations in an In Vivo Model of Alzheimer's Disease

Valeria D'Argenio et al.

Summary: The gut microbiota plays a crucial role in the development and progression of Alzheimer's disease (AD), and understanding the underlying mechanisms can help develop targeted therapies and diagnostic biomarkers. In this study, the gut microbiome and mycobiome of AD mice were characterized to identify specific microbial alterations. The results showed a pro-inflammatory status and AD-related pathogenetic features, suggesting a close connection between bacterial dysbiosis and AD. Further metagenomic studies are needed to explore the mechanisms in detail.

GENES (2022)

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Article Nutrition & Dietetics

The dietary treatment of histamine intolerance reduces the abundance of some histamine-secreting bacteria of the gut microbiota in histamine intolerant women. A pilot study

Sonia Sanchez-Perez et al.

Summary: Restrictive diets can change the composition of intestinal microbiota and have an impact on the treatment of histamine intolerance. This preliminary study found that a dietary treatment for histamine intolerance led to a reduction in histamine-secreting bacteria and an increase in a bacterial group associated with gut health.

FRONTIERS IN NUTRITION (2022)

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Article Biochemistry & Molecular Biology

Development of Neuroprotective Agents for the Treatment of Alzheimer's Disease Using Conjugates of Serotonin with Sesquiterpene Lactones.

Olga Sukocheva et al.

CURRENT MEDICINAL CHEMISTRY (2022)

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Article Cell Biology

Intermittent fasting protects against Alzheimer's disease in mice by altering metabolism through remodeling of the gut microbiota

Rui-Yuan Pan et al.

Summary: Intermittent fasting (IF) improves cognitive functions and ameliorates Alzheimer's disease pathology in a transgenic mouse model. The beneficial effects of IF are mediated by altered gut microbiota composition and metabolic activities.

NATURE AGING (2022)

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Article Clinical Neurology

Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites

Felix S. Meier-Stephenson et al.

Summary: Alzheimer's disease involves neurotoxic inflammation and amyloid beta oligomerization, and we conducted studies to understand the molecular mechanisms of cytokine-mediated and A beta-mediated neurotoxicities. Based on these findings, we designed potential small-molecule therapeutics for AD.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2022)

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Review Geriatrics & Gerontology

Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease

Xiao-hang Qian et al.

Summary: Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. They play a role in various physiological and pathological processes in the human body, including potential roles and mechanisms in neurodegenerative diseases such as Alzheimer's disease.

AGING AND DISEASE (2022)

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Review Biochemistry & Molecular Biology

Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders

Thomas Prevot et al.

Summary: Cognitive dysfunctions are a common occurrence in depression, other psychiatric disorders, and aging, potentially linked to altered GABA activity, specifically involving a decrease in the function of SST+ GABA neurons, leading to cognitive impairments.

MOLECULAR PSYCHIATRY (2021)

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Review Medicine, Research & Experimental

Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease

Periyanaina Kesika et al.

Summary: Gut microbiota plays a crucial role in the development of Alzheimer's disease (AD) through dysbiosis, leading to inflammatory signaling pathway disturbances that promote neuroinflammation and neuronal death. Understanding the relationship between gut microbiota and CNS can help identify probiotic-based supplementation as a potential therapeutic option for AD.

LIFE SCIENCES (2021)

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Article Immunology

Transplantation of gut microbiota derived from Alzheimer's disease mouse model impairs memory function and neurogenesis in C57BL/6 mice

Namkwon Kim et al.

Summary: Alzheimer's disease is a neurodegenerative disease that causes memory and cognitive decline. Recent studies suggest that gut microbiota may play a role in the disease. In this study, fecal microbiota transplantation from 5xFAD mice into normal mice resulted in decreased neurogenesis and memory impairment.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Neurosciences

Gut Microbiota Alterations and Cognitive Impairment Are Sexually Dissociated in a Transgenic Mice Model of Alzheimer's Disease

Daniel Cuervo-Zanatta et al.

Summary: This study reveals a sex-dependent association between gut microbiota alterations and cognitive impairment in a mouse model of Alzheimer's disease. Sex differences were observed in cognitive skills in wildtype mice, favoring females, but this advantage was lost in transgenic mice. Transgenic male mice exhibited more severe dysbiosis compared to transgenic females.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Review Clinical Neurology

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Fangda Leng et al.

Summary: Microglial activation and neuroinflammation play important roles in Alzheimer's disease, affecting disease progression and pathologies. Current research focuses on the interplay between neuroinflammation and amyloid and tau pathologies, with a specific interest in modulating microglia as a therapeutic strategy for AD.

NATURE REVIEWS NEUROLOGY (2021)

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Review Immunology

Microglia: Immune and non-immune functions

Katharina Borst et al.

Summary: Microglia, as resident macrophages of the CNS, play crucial roles in maintaining brain homeostasis and responding to disease, through intricate bidirectional communication with other brain cells and infiltrating peripheral immune cells. This harmonious cell-cell communication is essential for maintaining tissue health and overcoming pathology such as neuroinflammation.

IMMUNITY (2021)

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Article Neurosciences

High-fat diet alters stress behavior, inflammatory parameters and gut microbiota in Tg APP mice in a sex-specific manner

Natalia Yanguas-Casas et al.

Summary: Long-term high-fat diet can lead to obesity and inflammation, affecting gut microbiota. The effects of diet vary between sexes and genotypes of mice, with female TgAPP mice showing some resistance to diet-induced effects.

NEUROBIOLOGY OF DISEASE (2021)

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Article Allergy

Gut microbiota development during infancy: Impact of introducing allergenic foods

Tom Marrs et al.

Summary: The study found that characteristics of the infant gut microbiota at 3 months were related to cesarean birth, with a higher abundance of Clostridium sensu stricto at 3 months being positively correlated with atopic dermatitis. Transition to Bacteroides-rich communities and influx of adult-specific microbes were observed during the first year of life in selected cases and controls with longitudinal samples. The introduction of allergenic solids from 3 months alongside breast-feeding led to a significant increase in Shannon diversity and specific microbial representation, such as genera belonging to Prevotellaceae and Proteobacteria (e.g. Escherichia/Shigella).

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

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Review Neurosciences

Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin et al.

Summary: The article highlights the challenges and uncertainties surrounding reactive astrocytes, advocating for comprehensive research that includes assessment of multiple molecular and functional parameters, preferably in vivo, along with multivariate statistics and determination of impact on pathological hallmarks in relevant models.

NATURE NEUROSCIENCE (2021)

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Review Nutrition & Dietetics

Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health

Jasmine F. Millman et al.

Summary: Extra-virgin olive oil is rich in beneficial components that have positive effects on cardiovascular metabolic health and neuroprotection. Recent data suggest that its benefits may also extend to gut microbiota, improving outcomes in cardiovascular, metabolic, and cognitive health through modulation of microbial composition, production of microbial products, and activity of the mucosal immune system.

NUTRITION REVIEWS (2021)

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Review Cell Biology

GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease

Joan Jimenez et al.

Summary: This review focuses on the potential role of the GABAergic system in age-related episodic memory impairments, particularly in Alzheimer's disease. Research suggests that GABA plays a central role in regulating neuronal signaling in the hippocampus, which undergoes significant changes in AD, highlighting GABA as a key factor in the development of AD-related episodic memory decline.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

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Review Nutrition & Dietetics

Crosstalk between Gut and Brain in Alzheimer's Disease: The Role of Gut Microbiota Modulation Strategies

Umair Shabbir et al.

Summary: The gut microbiota can influence brain immune homeostasis through the microbiota-gut-brain axis and play a key role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Modulating GM through diet, probiotics, or fecal microbiota transplantation may represent potential therapeutic strategies in treating AD.

NUTRIENTS (2021)

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Review Biochemistry & Molecular Biology

Alzheimer's Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models

Maria Jose Carranza-Naval et al.

Summary: Alzheimer's disease (AD) and type 2 diabetes (T2DM) are associated with gut microbiota composition, inflammation, and microglia, with potential implications for disease development and progression. Further research is needed to fully understand the impact of diet, microbiome, and inflammation on AD and T2DM.

BIOMOLECULES (2021)

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Review Immunology

The Role of the Microbiota in Graves' Disease and Graves' Orbitopathy

Jueyu Hou et al.

Summary: Graves' disease is a common autoimmune disorder affecting the thyroid, heart, and other systems, with a significant negative impact on quality of life. Research suggests that gut microbiota may play a key role in the pathogenesis of GD/GO.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Tryptophan Metabolism and Gut-Brain Homeostasis

William Roth et al.

Summary: Tryptophan is crucial for protein synthesis and neurotransmitter production, impacting emotional regulation and nervous system development. Dysregulation of tryptophan metabolism contributes to various neurological and psychiatric disorders. The influence of gut microbes on tryptophan metabolism is being explored as a potential therapeutic target for these conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Psychology, Developmental

Depicting the composition of gut microbiota in children with tic disorders: an exploratory study

Wenjie Xi et al.

Summary: The study found differences in the gut microbiota profile of children with tic disorder compared to healthy controls, potentially related to distinct bacterial species and metabolic functions. The use of a random forest model accurately distinguished tic disorder from healthy controls, with significant correlations observed between tic symptom severity and specific bacterial species and gut microbiota metabolic functions. Additionally, DRA drug treatment in tic disorder children led to changes in the gut microbiota composition and metabolism, including an increase in potential enteric pathogens and alterations in various metabolic functions.

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2021)

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Article Immunology

A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease

Shuxuan Huang et al.

Summary: The study indicated that NLRP3, not NLRP1, NLRP2, NLRC4, and AIM2, may be the key inflammasome in promoting MPTP-induced Parkinson's disease pathogenesis. The NLRP3 inhibitor MCC950 showed neuroprotective effects in the MPTP-induced mouse model, suggesting its potential as a novel therapeutic approach for PD.

JOURNAL OF NEUROIMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

Roles of Sex Hormones and Gender in the Gut Microbiota

Kichul Yoon et al.

Summary: The distribution of gut microbiota varies by age and sex, impacting gastrointestinal diseases and being linked to sex hormone metabolism. The concept of "microgenderome" has been proposed, indicating the role of sex hormones on gut microbiota. Further research is needed to universally accept this concept.

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2021)

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Review Cell Biology

Potential roles of gut microbiota and microbial metabolites in Parkinson's disease

Shen-Yuan Zheng et al.

Summary: This review discusses the relationship between gut microbiota and PD, as well as their potential mechanisms, and explores the controversial roles of microbial metabolites in PD. It also evaluates the current treatments for PD and those targeting microbiota.

AGEING RESEARCH REVIEWS (2021)

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Article Medicine, General & Internal

Cognitive function improvement after fecal microbiota transplantation in Alzheimer's dementia patient: a case report

Soo-Hyun Park et al.

Summary: After fecal microbiota transplantation (FMT) for Clostridioides difficile infection (CDI), cognitive improvement was observed, indicating a significant association between gut microbiome and neural function. Changes in microbiota composition were found in recipient feces after FMT, with genera associated with cognitive function being reported. This suggests a connection between gut microbiome and cognitive function, emphasizing the potential of FMT as a therapy for dementia patients.

CURRENT MEDICAL RESEARCH AND OPINION (2021)

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Review Biochemistry & Molecular Biology

Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function

Elizabeth C. Rose et al.

Summary: This review summarizes the effects of probiotics and prebiotics on the intestinal epithelial barrier and non-epithelial barrier constituents, such as the enteric glial cell network, and investigates their potential therapeutic benefits in preventing and treating gastrointestinal diseases associated with impaired intestinal barrier function and dysbiosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Amyloid-β Pathway in Alzheimer's Disease

Harald Hampel et al.

Summary: Breakthroughs in molecular medicine have highlighted the significance of the amyloid-beta pathway in the pathophysiology of Alzheimer's disease. Established biochemical alterations of the A beta cycle serve as promising targets for the development of disease-modifying therapies. Research indicates a crucial role of A beta pathway dyshomeostasis in the dynamics of AD pathophysiology, supporting the development of A beta-targeting therapeutic strategies for early treatment of AD.

MOLECULAR PSYCHIATRY (2021)

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Review Clinical Neurology

Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus

Brianne M. Bettcher et al.

Summary: The dysregulation of central and peripheral immune responses in Alzheimer's disease has raised questions about the communication between these systems and its potential as a therapeutic target. While evidence suggests the importance of peripheral-central immune crosstalk in AD, further research is needed to understand the mechanisms and implications for therapeutic interventions. This roadmap provides a comprehensive overview of the current status of research in this area and outlines a research prospectus for future interdisciplinary studies.

NATURE REVIEWS NEUROLOGY (2021)

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Review Nutrition & Dietetics

Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

Yijing Chen et al.

Summary: Emerging evidence suggests that gut microbiota plays a crucial role in regulating brain activity and cognitive functions through the microbiota-gut-brain axis. The mechanisms by which gut microbiota regulate neurotransmitter production, transportation, and functioning are not well understood, nor are the effects of these interactions on normal brain functions and cognition. Dysbiosis of the microbiome can adversely affect cognitive function, particularly in neurodegenerative diseases like Alzheimer's and Parkinson's.

NUTRIENTS (2021)

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Review Geriatrics & Gerontology

Can Control Infections Slow Down the Progression of Alzheimer's Disease? Talking About the Role of Infections in Alzheimer's Disease

Mingchao Shi et al.

Summary: Alzheimer's disease is a global public health priority affecting over 40 million people worldwide. The role of infections in the pathogenesis of Alzheimer's disease is still unclear, but recent studies suggest that infection and chronic inflammation may be crucial risk factors. While the causal relationship between infection and Alzheimer's disease is difficult to determine, infections may act as accelerators in the progression of the disease. Conducting longitudinal studies and randomized controlled trials in humans to explore the links between infection and Alzheimer's disease could lead to more promising clinical therapeutic strategies.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Review Food Science & Technology

Probiotics for Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis

Guangsu Zhu et al.

Summary: Analysis of randomized controlled trials suggests that dietary supplementation with probiotics may improve cognitive function, particularly in individuals with mild cognitive impairment.

FOODS (2021)

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Review Medicine, General & Internal

Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases

Charlotte Thomas et al.

Summary: The oral cavity harbors a diverse microbiota community that impacts both oral and systemic health. Dysbiosis in the oral microbiota can lead to major infections and chronic systemic diseases, making it a novel target for diagnosis and treatment. Collaboration between oral specialists and general health specialists is crucial in improving overall patient wellbeing.

DIAGNOSTICS (2021)

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Article Neurosciences

Can Porphyromonas gingivalis Contribute to Alzheimer's Disease Already at the Stage of Gingivitis?

Ingar Olsen

Summary: Alzheimer's disease has been linked to periodontitis, with bacteria and inflammatory mediators from gingivitis possibly promoting brain inflammation. Research suggests that periodontal pathogens could drive brain resident macrophage cells into a pro-inflammatory state, contributing to Alzheimer's disease.

JOURNAL OF ALZHEIMERS DISEASE REPORTS (2021)

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Review Gastroenterology & Hepatology

Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease

Magdalena K. Stoeva et al.

Summary: Clostridium butyricum has been investigated as a probiotic for various human diseases with well-established safety. Its health benefits are mediated through molecular and immune signals that affect multiple organ systems.

GUT MICROBES (2021)

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Article Pharmacology & Pharmacy

Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

Xueqin Yang et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Clinical Neurology

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients

Elisabeth Sanchez-Mejias et al.

BRAIN PATHOLOGY (2020)

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Article Gastroenterology & Hepatology

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model

Min-Soo Kim et al.

GUT (2020)

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Review Cell Biology

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

Alessandra Webers et al.

IMMUNOLOGY AND CELL BIOLOGY (2020)

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Review Clinical Neurology

The gut microbiome in neurological disorders

John F. Cryan et al.

LANCET NEUROLOGY (2020)

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Article Gastroenterology & Hepatology

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

Tarini Shankar Ghosh et al.

GUT (2020)

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Article Immunology

Amyloid beta and diabetic pathology cooperatively stimulate cytokine expression in an Alzheimer's mouse model

Sitara B. Sankar et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Review Neurosciences

The multiplex model of the genetics of Alzheimer's disease

Rebecca Sims et al.

NATURE NEUROSCIENCE (2020)

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Review Neurosciences

The microbiota-immune axis as a central mediator of gut-brain communication

Thomas C. Fung

NEUROBIOLOGY OF DISEASE (2020)

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Review Nutrition & Dietetics

Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases

Edwin E. Martinez Leo et al.

NUTRITION (2020)

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Review Pharmacology & Pharmacy

Oral microbiota and Alzheimer's disease: Do all roads lead to Rome?

Antoni Sureda et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Food Science & Technology

Polyphenol supplementation benefits human health via gut microbiota: A systematic review via meta-analysis

Guiling Ma et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Review Medicine, General & Internal

The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer's Disease: A Systematic Review

Mario Dioguardi et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Nutrition & Dietetics

Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain

Kan Gao et al.

ADVANCES IN NUTRITION (2020)

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Article Immunology

Gastrointestinal (GI) Tract Microbiome-Derived Neurotoxins-Potent Neuro-Inflammatory Signals From the GI Tract via the Systemic Circulation Into the Brain

Walter J. Lukiw

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Microbiology

Potential TMA-Producing Bacteria Are Ubiquitously Found in Mammalia

Silke Rath et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Neurosciences

Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains

Ursula Haditsch et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Review Neurosciences

Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?

Carolina Pellegrini et al.

PROGRESS IN NEUROBIOLOGY (2020)

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Article Food Science & Technology

Differential effects of inulin or its fermentation metabolites on gut barrier and immune function of porcine intestinal epithelial cells

Julie Uerlings et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Review Nutrition & Dietetics

Dietary Approaches to Stop Hypertension (DASH) Diet and Blood Pressure Reduction in Adults with and without Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Christina D. Filippou et al.

ADVANCES IN NUTRITION (2020)

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Review Immunology

Fecal Microbiota Transplantation in Neurological Disorders

Karuna E. W. Vendrik et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Neurosciences

Disease-associated astrocytes in Alzheimer's disease and aging

Naomi Habib et al.

NATURE NEUROSCIENCE (2020)

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Editorial Material Clinical Neurology

Do infections have a role in the pathogenesis of Alzheimer disease?

Ruth F. Itzhaki et al.

NATURE REVIEWS NEUROLOGY (2020)

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Review Dentistry, Oral Surgery & Medicine

Periodontal disease as a possible cause for Alzheimer's disease

Angela R. Kamer et al.

PERIODONTOLOGY 2000 (2020)

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Article Pharmacology & Pharmacy

The gut microbiota confers protection in the CNS against neurodegeneration induced by manganism

Hui Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Microbiology

The Microbiome as a Modifier of Neurodegenerative Disease Risk

P. Fang et al.

CELL HOST & MICROBE (2020)

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Review Cell Biology

The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation

Chiara Amoroso et al.

CELLS (2020)

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Review Immunology

Periodontal Disease and Periodontal Disease-Related Bacteria Involved in the Pathogenesis of Alzheimer's Disease

Kenji Matsushita et al.

JOURNAL OF INFLAMMATION RESEARCH (2020)

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Article Medicine, Research & Experimental

Rapid improvement in Alzheimer's disease symptoms following fecal microbiota transplantation: a case report

Sabine Hazan

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

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Article Clinical Neurology

New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota

Heping Shen et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2020)

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Article Multidisciplinary Sciences

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

Lukas F. Mager et al.

SCIENCE (2020)

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Article Neurosciences

Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer's Disease

Moira Marizzoni et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Article Neurosciences

Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment

Shan Liu et al.

MOLECULAR NEUROBIOLOGY (2020)

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Review Immunology

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

Michael V. Sofroniew

TRENDS IN IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Bacterial Metabolites of Human Gut Microbiota Correlating with Depression

Olga Averina et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Immunology

The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology

Andrina Rutsch et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Neurosciences

Porphyromonas gingivalis is a Strong Risk Factor for Alzheimer's Disease

Shalini Kanagasingam et al.

JOURNAL OF ALZHEIMERS DISEASE REPORTS (2020)

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Article Biochemistry & Molecular Biology

Commensal Microbiota Modulation of Natural Resistance to Virus Infection

Kailyn L. Stefan et al.

CELL (2020)

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Review Integrative & Complementary Medicine

Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics

Christine Tara Peterson

JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE (2020)

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Review Neurosciences

Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease

Eleonora Ambrad Giovannetti et al.

BRAIN RESEARCH (2019)

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Review Neurosciences

Is Alzheimer's Disease Risk Modifiable?

Alberto Serrano-Pozo et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Article Multidisciplinary Sciences

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Stephen S. Dominy et al.

SCIENCE ADVANCES (2019)

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Article Cell Biology

Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice

Fan Yu et al.

AGING-US (2019)

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Article Immunology

Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort

Ping Liu et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

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Article Immunology

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

Hemraj B. Dodiya et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Review Immunology

Antibiotics, gut microbiota, and Alzheimer's disease

Francesco Angelucci et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Biochemistry & Molecular Biology

The pros, cons, and many unknowns of probiotics

Jotham Suez et al.

NATURE MEDICINE (2019)

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Article Microbiology

Effects of Bifidobacterium breve A1 on the cognitive function of older adults with memory complaints: a randomised, double-blind, placebo-controlled trial

Y. Kobayashi et al.

BENEFICIAL MICROBES (2019)

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Article Neurosciences

Gut Microbiota Alteration and Its Time Course in a Tauopathy Mouse Model

Bin-Lu Sun et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Article Nutrition & Dietetics

Fecal Microbial Diversity and Structure Are Associated with Diet Quality in the Multiethnic Cohort Adiposity Phenotype Study

Gertraud Maskarinec et al.

JOURNAL OF NUTRITION (2019)

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Review Behavioral Sciences

Diet and Alzheimer's dementia - Nutritional approach to modulate inflammation

Katarzyna Szczechowiak et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2019)

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Article Multidisciplinary Sciences

A novel synbiotic delays Alzheimer's disease onset via combinatorial gut-brain-axis signaling in Drosophila melanogaster

Susan Westfall et al.

PLOS ONE (2019)

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Review Neurosciences

Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer's Disease and Multiple Sclerosis

Adham Fani Maleki et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Review Geriatrics & Gerontology

Modifiable Risk Factors for Alzheimer's Disease

George A. Edwards et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

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Article Clinical Neurology

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota

Binyin Li et al.

ALZHEIMERS & DEMENTIA (2019)

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Article Cell Biology

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression

Xinyi Wang et al.

CELL RESEARCH (2019)

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Review Clinical Neurology

Astrocytes: From the Physiology to the Disease

Laura Trujillo-Estrada et al.

CURRENT ALZHEIMER RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Justin M. Long et al.

CELL (2019)

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Article Neurosciences

Porphyromonas gingivalis Infection Induces Amyloid-beta Accumulation in Monocytes/Macrophages

Ran Nie et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Article Neurosciences

Discovery of Gut Bacteria Specific to Alzheimer's Associated Diseases is a Clue to Understanding Disease Etiology: Meta-Analysis of Population-Based Data on Human Gut Metagenomics and Metabolomics

Elena L. Paley

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Article Nutrition & Dietetics

Immunomodulatory Effect of Gut Microbiota-Derived Bioactive Peptides on Human Immune System from Healthy Controls and Patients with Inflammatory Bowel Disease

Samuel Fernandez-Tome et al.

NUTRIENTS (2019)

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Article Geriatrics & Gerontology

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Dora Abraham et al.

EXPERIMENTAL GERONTOLOGY (2019)

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Article Nutrition & Dietetics

Effects of prebiotics on immunologic indicators and intestinal microbiota structure in perioperative colorectal cancer patients

Xiaoliang Xie et al.

NUTRITION (2019)

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Review Gastroenterology & Hepatology

Brain-Gut-Microbiota Axis in Alzheimer's Disease

Karol Kowalski et al.

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2019)

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Article Microbiology

GABA-modulating bacteria of the human gut microbiota

Philip Strandwitz et al.

NATURE MICROBIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Characterization of inflammation and insulin resistance in high-fat diet-induced male C57BL/6J mouse model of obesity

Dimiter Avtanski et al.

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2019)

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Review Clinical Neurology

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms

Lap Ho et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2018)

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Review Clinical Neurology

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms

Lap Ho et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2018)

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Review Clinical Neurology

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

Carolina Pellegrini et al.

ACTA NEUROPATHOLOGICA (2018)

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Article Cell Biology

Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice

Gaofeng Zhan et al.

AGING-US (2018)

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Article Clinical Neurology

Understanding the impact of sex and gender in Alzheimer's disease: A call to action

Rebecca A. Nebel et al.

ALZHEIMERS & DEMENTIA (2018)

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Article Neurosciences

Neurotransmitter modulation by the gut microbiota

Philip Strandwitz

BRAIN RESEARCH (2018)

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Review Microbiology

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Allison Agus et al.

CELL HOST & MICROBE (2018)

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Review Clinical Neurology

Evaluation of Metabolic and Synaptic Dysfunction Hypotheses of Alzheimer's Disease (AD): A Meta-Analysis of CSF Markers

Roni Manyevitch et al.

CURRENT ALZHEIMER RESEARCH (2018)

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Article Geriatrics & Gerontology

Oral function as an indexing parameter for mild cognitive impairment in older adults

Yutaka Watanabe et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2018)

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Article Gastroenterology & Hepatology

Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis

M. Anthony Sofia et al.

INFLAMMATORY BOWEL DISEASES (2018)

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Review Neurosciences

Past to Future: What Animal Models Have Taught Us About Alzheimer's Disease

Alessandra C. Martini et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Neurosciences

Gut Microbiota is Altered in Patients with Alzheimer's Disease

Zhen-Qian Zhuang et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Review Neurosciences

Association between Alzheimer's Disease and Oral and Gut Microbiota: Are Pore Forming Proteins the Missing Link?

Sebastian Aguayo et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Biochemical Research Methods

Widely targeted metabolomics of Alzheimer's disease postmortem cerebrospinal fluid based on 9-fluorenylmethyl chloroformate derivatized ultra-high performance liquid chromatography tandem mass spectrometry

Yoshio Muguruma et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2018)

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Article Immunology

Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice

Jing Zhang et al.

JOURNAL OF NEUROINFLAMMATION (2018)

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Article Biotechnology & Applied Microbiology

Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan

C. Baeuerl et al.

LETTERS IN APPLIED MICROBIOLOGY (2018)

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Article Biochemical Research Methods

Methodological considerations for the identification of choline and carnitine-degrading bacteria in the gut

Eleanor Jameson et al.

METHODS (2018)

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Article Neurosciences

SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model

Laura Bonfili et al.

MOLECULAR NEUROBIOLOGY (2018)

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Review Clinical Neurology

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Steven E. Arnold et al.

NATURE REVIEWS NEUROLOGY (2018)

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Review Geriatrics & Gerontology

Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative

Victoria Navarro et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

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Article Multidisciplinary Sciences

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

Vladimir Ilievski et al.

PLOS ONE (2018)

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Review Multidisciplinary Sciences

Microbial tryptophan catabolites in health and disease

Henrik M. Roager et al.

NATURE COMMUNICATIONS (2018)

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Article Clinical Neurology

The antimicrobial protection hypothesis of Alzheimer's disease

Robert D. Moir et al.

ALZHEIMERS & DEMENTIA (2018)

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Review Neurosciences

Peripheral immune system in aging and Alzheimer's disease

Wei Cao et al.

MOLECULAR NEURODEGENERATION (2018)

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Review Nutrition & Dietetics

Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer's Disease

Vo Van Giau et al.

NUTRIENTS (2018)

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Review Multidisciplinary Sciences

Recent developments in understanding the role of the gut microbiota in brain health and disease

Eoin Sherwin et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Aurelia Santoro et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Article Neurosciences

Altered Gut Microbiota in a Mouse Model of Alzheimer's Disease

Ling Zhang et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Review Neurosciences

The Gut Microbiota and Alzheimer's Disease

Chunmei Jiang et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Article Neurosciences

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model

Carolin Brandscheid et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Article Neurosciences

Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer's Disease?

Alice Harding et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Review Clinical Neurology

Peripheral inflammatory markers in Alzheimer's disease: a systematic review and meta-analysis of 175 studies

Ka Sing P. Lai et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)

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Review Neurosciences

Interactions between the microbiota, immune and nervous systems in health and disease

Thomas C. Fung et al.

NATURE NEUROSCIENCE (2017)

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Editorial Material Gastroenterology & Hepatology

Brain-gut-microbiota axis-mood, metabolism and behaviour

Timothy G. Dinan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Glenn R. Gibson et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Geriatrics & Gerontology

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Annamaria Cattaneo et al.

NEUROBIOLOGY OF AGING (2017)

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Article Immunology

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

Yuhai Zhao et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

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Article Microbiology

In Silico Screening of the Human Gut Metaproteome Identifies Th17-Promoting Peptides Encrypted in Proteins of Commensal Bacteria

Claudio Hidalgo-Cantabrana et al.

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Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease

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Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice

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Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress

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Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer's disease

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Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression

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Current Understanding of Dysbiosis in Disease in Human and Animal Models

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Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-β1-42-induced rat model of Alzheimer's disease

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Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

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Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate

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Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

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Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

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Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease

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MIND diet associated with reduced incidence of Alzheimer's disease

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Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

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Diet Dominates Host Genotype in Shaping the Murine Gut Microbiota

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Influence of high-fat diet on gut microbiota: a driving force for chronic disease risk

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Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

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Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

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Host microbiota constantly control maturation and function of microglia in the CNS

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Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated

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High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism

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Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms

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Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro

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Association of Mediterranean Diet with Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis

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The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

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GAD65, GAD67, and GABAT Immunostaining in Human Brain and Apparent GAD65 Loss in Alzheimer's Disease

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Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

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Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial

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Age-Associated Remodeling of the Intestinal Epithelial Barrier

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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

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GALACTOOLIGOSACCHARIDE IMPROVES THE ANIMAL SURVIVAL AND ALLEVIATES MOTOR NEURON DEATH IN SOD1G93A MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

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Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain

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The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against A beta Plaque Pathology

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Role of the gut microbiota in immunity and inflammatory disease

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Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine

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γ-Aminobutyric acid production by culturable bacteria from the human intestine

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Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells

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Resistant Starch from High-Amylose Maize Increases Insulin Sensitivity in Overweight and Obese Men

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The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept)

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Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

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Selective C-Rel Activation via Malt1 Controls Anti-Fungal T-H-17 Immunity by Dectin-1 and Dectin-2

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A Meta-Analysis of Cytokines in Alzheimer's Disease

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Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

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The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

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Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

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Indole as an intercellular signal in microbial communities

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Immune adaptations that maintain homeostasis with the intestinal microbiota

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Defining the healthy core microbiome of oral microbial communities

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Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine

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The NIH Human Microbiome Project

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The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

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Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)

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16S rRNA gene sequence-based analysis of clostridia related to conversion of germfree mice to the normal state

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Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

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Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

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Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

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NEUROPSYCHOPHARMACOLOGY (2009)

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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

William R. Wikoff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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The gut microbiota shapes intestinal immune responses during health and disease

June L. Round et al.

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Animal models of Alzheimer's disease and frontotemporal dementia

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Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1 x APP transgenic model of Alzheimer's disease

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Interleukin-18 and transforming growth factor-beta 1 plasma levels in Alzheimer's disease and vascular dementia

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Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome

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GASTROENTEROLOGY (2004)

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Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

K Suzuki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

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The impact of systemic infection on the progression of neurodegenerative disease

VH Perry et al.

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Probiotics as a help in children suffering from malnutrition and diarrhoea

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GAT2/BGT-1 as a system responsible for the transport of γ-aminobutyric acid at the mouse blood-brain barrier

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