☆ 4.7 Article

Behavioral Effects and Analgesic Profile of Hemoglobin-Derived Valorphin and Its Synthetic Analog in Rodents

BIOMEDICINES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Neurosciences

Key differences in regulation of opioid receptors localized to presynaptic terminals compared to somas: Relevance for novel therapeutics

Basile Coutens et al.

Summary: Opioid receptors are G protein-coupled receptors (GPCRs) that regulate pain, reward, and aversion processing in the brain. They inhibit neurotransmitter release in presynaptic terminals and hyperpolarize neurons in postsynaptic locations. Activation of opioid receptors at the plasma membrane leads to regulatory processes such as phosphorylation and internalization of the receptors. The balance of opioid signaling in circuits expressing pre-and postsynaptic opioid receptors is shifted toward inhibition of presynaptic neurotransmitter release during continuous opioid exposure.

NEUROPHARMACOLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis and Biological Studies of Novel Aminophosphonates and Their Metal Carbonyl Complexes (Fe, Ru)

Aneta Kosinska et al.

Summary: The search for new inhibitors of biologically relevant targets is an important strategy in developing new drugs for the treatment of neurodegenerative diseases. A series of compounds were designed, synthesized, and evaluated for their inhibitory potential against acetylcholinesterase and butyrylcholinesterase. One of the compounds showed the strongest inhibition activity against acetylcholinesterase and cytotoxicity studies were also conducted.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Chemistry, Medicinal

Recent Synthesis, Characterization, and Pharmacological Evaluation of Multifunctional Hemorphins Containing Non-Natural Amino Acids with Potential Biological Importance

Petar Todorov et al.

Summary: This review summarizes the current studies on short-chain synthetic hemorphin peptide derivatives containing non-natural amino acids, focusing on the analysis of structure-activity relationship, specific methods for their characterization, and the advantages of synthetic hemorphin analogs compared to endogenous peptides.

PHARMACEUTICALS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antinociceptive Effects of VV-Hemorphin-5 Peptide Analogues Containing Amino phosphonate Moiety in Mouse Formalin Model of Pain

Borislav Assenov et al.

Summary: In this study, hemorphin analogues with amino phosphonate moiety were synthesized and tested for their antinociceptive activities in mice. The results showed that pVV-H and pLV-H analogues exhibited significant antinociceptive effects in acute and inflammatory pain, while pL-H and pLVV-H analogues were less effective. This study contributes to understanding the role of Valine and the number of amino acid residues in the effectiveness of hemorphin peptide analogs in suppressing experimental pain.

PROTEIN AND PEPTIDE LETTERS (2021)

添加到收藏夹

Review Chemistry, Medicinal

Hemorphins Targeting G Protein-Coupled Receptors

Mohammed Akli Ayoub et al.

Summary: Hemorphins, short peptides derived from hemoglobin's beta subunit, have diverse physiological effects, particularly in the nervous and renin-angiotensin systems. They modulate a variety of proteins, including enzymes and receptors, and target G protein-coupled receptors (GPCRs) pharmacologically and functionally. The implication of GPCRs in hemorphins' effects aids in understanding their molecular basis and suggests the hemorphin-GPCR axis as a potential therapeutic target in various systems.

PHARMACEUTICALS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Hemorphins-From Discovery to Functions and Pharmacology

Przemyslaw Mielczarek et al.

Summary: This review summarizes the current state-of-the-art regarding hemorphins, their methodological aspects of identification, and their potential therapeutic role. It covers a wide spectrum of characteristics and applications, combining analytical and pharmacological aspects of peptides described by a team who participated in the initial research on hemorphins.

MOLECULES (2021)

添加到收藏夹

Review Chemistry, Organic

α-Iminophosphonates: Useful Intermediates for Enantioselective Synthesis of α-Aminophosphonates

Aitor Maestro et al.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Biased signaling by endogenous opioid peptides

Ivone Gomes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Neurosciences

Thienorphine induces antinociception without dependence through activation of κ- and δ-, and partial activation of μ- opioid receptor

Peilan Zhou et al.

BRAIN RESEARCH (2020)

添加到收藏夹

Article Chemistry, Medicinal

Anticonvulsant evaluation and docking analysis of VV-Hemorphin-5 analogues

Petar Todorov et al.

DRUG DEVELOPMENT RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis, characterization and anticonvulsant activity of new series of N-modified analogues of VV-hemorphin-5 with aminophosphonate moiety

Petar Todorov et al.

AMINO ACIDS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular insights into the interaction of hemorphin and its targets

Amanat Ali et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis, characterization and nociceptive screening of new VV-hemorphin-5 analogues

Petar Todorov et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting multiple opioid receptors - improved analgesics with reduced side effects?

Thomas Guenther et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

添加到收藏夹

Article Neurosciences

The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel κ agonist and μ partial agonist, in mice

Qian Wang et al.

PSYCHOPHARMACOLOGY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Novel κ-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation

Le-sha Zhang et al.

ACTA PHARMACOLOGICA SINICA (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Therapeutic Potential of Nociceptin/Orphanin FQ Receptor Agonists as Analgesics without Abuse Liability

Ann P. Lin et al.

ACS CHEMICAL NEUROSCIENCE (2013)

添加到收藏夹

Letter Clinical Neurology

Diminution of hemoglobin-derived hemorphin: An underlying risk factor for cognitive deficit in diabetes

Chang Zheng Song et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of intraerythrocytic proteasome retards the generation of hemorphins

Chang Zheng Song et al.

PEPTIDES (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

LVV-hemorphin 7 and angiotensin IV in correlation with antinociception and anti-thermal hyperalgesia in rats

Bor-Chih Cheng et al.

PEPTIDES (2012)

添加到收藏夹

Article Multidisciplinary Sciences

CRF1-R Activation of the Dynorphin/Kappa Opioid System in the Mouse Basolateral Amygdala Mediates Anxiety-Like Behavior

Michael R. Bruchas et al.

PLOS ONE (2009)

添加到收藏夹

Article Pharmacology & Pharmacy

Anxiolytic-Like effects of κ-opioid receptor antagonists in models of unlearned and learned fear in rats

Allison T. Knoll et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.