期刊
BIOMEDICINES
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines11092387
关键词
heat shock protein 47; pulmonary fibrosis; anti-fibrotic agent; collagen; chaperon; SERPINH1; fibroblast; alveolar epithelial cell
Idiopathic pulmonary fibrosis is a chronic lung disease characterized by a decline in lung function and poor prognosis. Type I collagen, a major component of the extracellular matrix, is a potential target for fibrosis treatment. HSP47, a collagen-binding protein, is increased in pulmonary fibrosis and has implications in the development of therapeutic strategies.
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by a progressive decline in lung function and poor prognosis. The deposition of the extracellular matrix (ECM) by myofibroblasts contributes to the stiffening of lung tissue and impaired oxygen exchange in IPF. Type I collagen is the major ECM component and predominant collagen protein deposited in chronic fibrosis, suggesting that type I collagen could be a target of drugs for fibrosis treatment. Heat shock protein 47 (HSP47), encoded by the serpin peptidase inhibitor clade H, member 1 gene, is a stress-inducible collagen-binding protein. It is an endoplasmic reticulum-resident molecular chaperone essential for the correct folding of procollagen. HSP47 expression is increased in cellular and animal models of pulmonary fibrosis and correlates with pathological manifestations in human interstitial lung diseases. Various factors affect HSP47 expression directly or indirectly in pulmonary fibrosis models. Overall, understanding the relationship between HSP47 expression and pulmonary fibrosis may contribute to the development of novel therapeutic strategies.
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