Myocardial RNA Sequencing Reveals New Potential Therapeutic Targets in Heart Failure with Preserved Ejection Fraction

Review Cardiac & Cardiovascular Systems

Biomarkers for the diagnosis and management of heart failure

Vincenzo Castiglione et al.

Summary: Heart failure is a significant global health issue, and NPs are effective biomarkers for HF, with high-sensitivity troponins and soluble suppression of tumorigenesis-2 showing promise for risk stratification.

HEART FAILURE REVIEWS (2022)

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Article Multidisciplinary Sciences

Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice

Marit Jensen et al.

Summary: The deficiency of AGAT and the supplementation of creatine and hArg are associated with cardiac miRNA expression, which may influence cardiac (dys)function and cardiovascular disease (CVD).

SCIENTIFIC REPORTS (2022)

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Article Cardiac & Cardiovascular Systems

hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration

Jisheng Sun et al.

Summary: Research has identified a subset of epicardial cells in zebrafish that play a key role in heart regeneration, marked by expression of hapln1a and hapln1b. These cells are crucial in cardiac growth and regeneration, requiring the function of the hapln1b paralog for normal cardiomyocyte proliferation and muscle regeneration.

CIRCULATION (2022)

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Article Biochemistry & Molecular Biology

Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction

Maria J. Sebastiao et al.

Summary: Heart failure with preserved ejection fraction (HFpEF) is a clinical entity that is highly prevalent but still poorly understood. This study used advanced mass spectrometry to analyze protein-expression profiles in human left ventricular myocardial samples of HFpEF patients, revealing abnormalities in proteins associated with mitochondrial dysfunction, oxidative stress, and inflammation. The study also found that HFpEF patients with diabetes may have reduced mitochondrial function.

BIOMEDICINES (2022)

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Article Cardiac & Cardiovascular Systems

Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction

Virginia S. Hahn et al.

Summary: The study revealed distinctive transcriptomic signatures and molecular subgroupings in patients with HFpEF, with specific clinical features and outcomes. Obesity was found to be a major contributor to the upregulation of genes in HFpEF, while pathways related to endoplasmic reticulum stress, autophagy, and angiogenesis were identified as downregulated genes specific to HFpEF.

CIRCULATION (2021)

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Review Cardiac & Cardiovascular Systems

Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies

Nazha Hamdani et al.

Summary: HFpEF, described as the 'single largest unmet need in cardiovascular medicine', is currently untreatable and associated with poor prognosis and unsustainable healthcare costs. Epigenetic modifications play a significant role in the pathogenesis of HFpEF, offering potential for personalized management of heart failure.

EUROPEAN HEART JOURNAL (2021)

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Review Cardiac & Cardiovascular Systems

Current gaps in HFpEF trials: Time to reconsider patients' selection and to target phenotypes

Alberto Palazzuoli et al.

Summary: HFpEF is a prevalent clinical condition associated with cardiovascular aging, with differences in diagnostic criteria and patient selection in recent trials. Lack of standardization and population heterogeneity may explain the failure to show improved outcomes with different therapeutic interventions in HFpEF patients. The characterization of patients, cardiovascular risk, associated diseases, and disease progression features could provide insights for tailored treatments and mechanistic understanding.

PROGRESS IN CARDIOVASCULAR DISEASES (2021)

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Article Cardiac & Cardiovascular Systems

Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis

Vijayakrishna Kolur et al.

Summary: This study identified key genes and pathways involved in the progression of heart failure (HF) through high throughput sequencing analysis, showing their important roles in HF development. Additionally, the research revealed the association of HF with adaptive immune system and neutrophil degranulation, providing new insights into the molecular mechanisms of HF.

BMC CARDIOVASCULAR DISORDERS (2021)

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Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Theresa A. McDonagh et al.

EUROPEAN HEART JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Subtypes identification on heart failure with preserved ejection fraction via network enhancement fusion using multi-omics data

Yongqing Wu et al.

Summary: Heart failure with preserved ejection fraction (HFpEF) is a syndrome associated with multiple etiologic and patho-physiologic factors, leading to increased cardiovascular morbidity and mortality. Therapeutic interventions for HFpEF face challenges, but identifying clinical subtypes using multi-omics data can help in efficient treatment and prognosis.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

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Review Hematology

Aortic Valve Stenosis From Basic Mechanisms to Novel Therapeutic Targets

Philip Roger Goody et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Systematic Review of the Genetics of Sudden Unexpected Death in Epilepsy: Potential Overlap With Sudden Cardiac Death and Arrhythmia-Related Genes

C. Anwar A. Chahal et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Review Cardiac & Cardiovascular Systems

Epidemiology of heart failure

Amy Groenewegen et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

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Article Cell Biology

KCNQ1OT1 Exacerbates Ischemia-Reperfusion Injury Through Targeted Inhibition of miR-140-3P

Ming Yi et al.

INFLAMMATION (2020)

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Article Medicine, Research & Experimental

Molecular Signatures and Networks of Cardiomyocyte Differentiation in Humans and Mice

Yumei Wang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Multidisciplinary Sciences

Transcriptomics of cardiac biopsies reveals differences in patients with or without diagnostic parameters for heart failure with preserved ejection fraction

Sarbashis Das et al.

SCIENTIFIC REPORTS (2019)

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Article Neurosciences

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

Fumiaki Mori et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

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Article Biotechnology & Applied Microbiology

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure

Andrea Raso et al.

MOLECULAR THERAPY (2019)

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Review Cell Biology

Heart Failure with Reduced Ejection Fraction (HFrEF) and Preserved Ejection Fraction (HFpEF): The Diagnostic Value of Circulating MicroRNAs

Yei-Tsung Chen et al.

CELLS (2019)

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Review Biochemistry & Molecular Biology

Structure and function of the Nppa-Nppb cluster locus during heart development and disease

Joyce Man et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Review Clinical Neurology

Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction

Heinz Jungbluth et al.

NATURE REVIEWS NEUROLOGY (2018)

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Article Biochemical Research Methods

Selecting between-sample RNA-Seq normalization methods from the perspective of their assumptions

Ciaran Evans et al.

BRIEFINGS IN BIOINFORMATICS (2018)

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Article Cardiac & Cardiovascular Systems

Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction 5-Year Outcomes

Kevin S. Shah et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Oncology

Circulating miRNA-21 is a promising biomarker for heart failure

Jianghua Zhang et al.

MOLECULAR MEDICINE REPORTS (2017)

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Article Cardiac & Cardiovascular Systems

Precision Medicine for Heart Failure with Preserved Ejection Fraction: An Overview

Sanjiv J. Shah

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2017)

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Article Multidisciplinary Sciences

CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts

Chun-Mei Tang et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemical Research Methods

QuickMIRSeq: a pipeline for quick and accurate quantification of both known miRNAs and isomiRs by jointly processing multiple samples from microRNA sequencing

Shanrong Zhao et al.

BMC BIOINFORMATICS (2017)

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Article Cardiac & Cardiovascular Systems

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC

Piotr Ponikowski et al.

EUROPEAN JOURNAL OF HEART FAILURE (2016)

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Article Multidisciplinary Sciences

MiRComb: An R Package to Analyse miRNA-mRNA Interactions. Examples across Five Digestive Cancers

Maria Vila-Casadesus et al.

PLOS ONE (2016)

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Editorial Material Cardiac & Cardiovascular Systems

miR-21: a star player in cardiac hypertrophy

Burcu Duygu et al.

CARDIOVASCULAR RESEARCH (2015)

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Article Cardiac & Cardiovascular Systems

Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction

Lee Lee Wong et al.

EUROPEAN JOURNAL OF HEART FAILURE (2015)

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Article Biotechnology & Applied Microbiology

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

Mihaela Pertea et al.

NATURE BIOTECHNOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

Phenomapping for Novel Classification of Heart Failure With Preserved Ejection Fraction

Sanjiv J. Shah et al.

CIRCULATION (2015)

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Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

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Article Biology

RNA-seq: impact of RNA degradation on transcript quantification

Irene Gallego Romero et al.

BMC BIOLOGY (2014)

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Article Cardiac & Cardiovascular Systems

Developing Therapies for Heart Failure With Preserved Ejection Fraction Current State and Future Directions

Javed Butler et al.

JACC-HEART FAILURE (2014)

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Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

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Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

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Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure

Eric Rullman et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2013)

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Review Cardiac & Cardiovascular Systems

The role of natriuretic peptides in cardioprotection

T Nishikimi et al.

CARDIOVASCULAR RESEARCH (2006)

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Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays

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JOURNAL OF MOLECULAR ENDOCRINOLOGY (2000)

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Myocardial RNA Sequencing Reveals New Potential Therapeutic Targets in Heart Failure with Preserved Ejection Fraction

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