4.7 Article

Ghrelin Amplifies the Nicotine-Induced Release of Dopamine in the Bed Nucleus of Stria Terminalis (BNST)

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Ghrelin activates the mesolimbic dopamine system via nitric oxide associated mechanisms in the ventral tegmental area

Jorgen A. Engel et al.

Summary: In addition to promoting feeding, the peptide ghrelin also activates the mesolimbic dopamine system and causes reward-related behaviors. This study found that the gaseous neurotransmitter nitric oxide (NO) is involved in the activation of the dopamine system by ghrelin. Inhibition of NO synthesis and downstream signaling prevented ghrelin's effects on reward-related behaviors. These findings suggest that ghrelin increases NO levels in the ventral tegmental area (VTA) and stimulates reward-related behaviors through NO signaling.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2023)

Article Neurosciences

Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice

Rani S. Richardson et al.

Summary: This study found that GHSR antagonists reduced alcohol intake in male and female mice, indicating the important role of central GHSR in mediating binge-like drinking behavior.

NEUROPHARMACOLOGY (2023)

Article Biochemistry & Molecular Biology

A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data

Sara L. Deschaine et al.

Summary: Alcohol decreases ghrelin levels in both rats and humans, but this decrease is not in proportion to alcohol's caloric value or through direct interaction with the ghrelin system.

ADDICTION BIOLOGY (2022)

Article Behavioral Sciences

Circulating ghrelin changes as a biomarker of the stress response and craving in abstinent smokers

Sheena Potretzke et al.

Summary: The study found that ghrelin is sensitive to acute stress and may serve as a marker for stress, craving, and smoking relapse.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2022)

Review Substance Abuse

Role of the ghrelin system in alcohol use disorder and alcohol-associated liver disease: A narrative review

Kusum K. Kharbanda et al.

Summary: Unhealthy alcohol consumption is a global health issue that has adverse consequences on individuals, public health, and society. Alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) are the most common pathologies among alcohol-related diseases. The liver is particularly vulnerable to alcohol-induced damage due to its role in alcohol metabolism. Currently, the only effective approaches to treating ALD are alcohol abstinence or liver transplantation. Ghrelin, a hormone primarily produced by the stomach, has dual effects on addictive behaviors and metabolic pathways, making it a potential therapeutic target for AUD and ALD. This review discusses recent advancements in understanding the peripheral and central functions of the ghrelin system and its involvement in AUD and ALD pathogenesis. The correlation between blood ghrelin levels and alcohol use or abstinence is examined, as well as the role of ghrelin in alcohol-seeking behaviors and the development of fatty liver. A better understanding of the ghrelin system could lead to improved treatments for AUD and its medical consequences, including ALD.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2022)

Article Neurosciences

Changes in plasma ghrelin levels following surgical and non-surgical weight-loss in female rats predict alcohol use

Elise Orellana et al.

Summary: Accumulating clinical evidence suggests that patients receiving Roux-en Y gastric bypass (RYGB) surgery may be at increased risk of developing alcohol use disorder. Sleeve gastrectomy (SG) surgery, on the other hand, has been shown to decrease alcohol consumption. The differential alcohol outcomes after RYGB versus SG may be related to the gut hormone ghrelin.

BRAIN RESEARCH BULLETIN (2022)

Article Neurosciences

Role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis in nicotine withdrawal-induced aversive behavior

Saya Arakaki et al.

Summary: The results demonstrate that enhanced noradrenergic transmission via beta-adrenoceptors in the ventral bed nucleus of the stria terminalis (vBNST) plays a crucial role in nicotine withdrawal-induced aversive behavior.

NEUROPSYCHOPHARMACOLOGY REPORTS (2022)

Article Biochemistry & Molecular Biology

Nicotine, cocaine, amphetamine, morphine, and ethanol increase norepinephrine output in the bed nucleus of stria terminalis of freely moving rats

Dragana Jadzic et al.

Summary: The bed nucleus of stria terminalis (BNST), an important limbic area, is involved in neuroendocrine, behavioral responses, and stress regulation. Drugs of abuse increase norepinephrine transmission in the BNST, contributing to the development of stress-induced drug seeking behavior.

ADDICTION BIOLOGY (2021)

Article Psychology, Clinical

Early life adversity and appetite hormones: The effects of smoking status, nicotine withdrawal, and relapse on ghrelin and peptide YY during smoking cessation

Mustafa Al'Absi et al.

Summary: Evidence suggests that ghrelin and PYY may modulate stress responses and drug rewarding effects, with early life stress possibly impacting these hormones in smokers and during smoking cessation. The study found a positive association between early life adversity and elevated ghrelin in nonsmokers, while successful quitters had higher ghrelin levels during ad libitum smoking compared to nonsmokers. This research highlights the importance of considering changes in appetite-related hormones in individuals dependent on tobacco.

ADDICTIVE BEHAVIORS (2021)

Article Behavioral Sciences

Cell-type diversity in the bed nucleus of the stria terminalis to regulate motivated behaviors

Maria M. Ortiz-Juza et al.

Summary: The bed nucleus of the stria terminalis (BNST) has gained popularity in recent decades as a unique brain region involved in regulating motivated behaviors related to neuropsychiatric disorders. However, the precise mechanisms by which BNST regulates distinct motivational states remain largely unclear due to high molecular heterogeneity found within BNST neurons. Single-cell RNA sequencing data reveal multiple genetically identifiable cell-type clusters in BNST, which can be targeted and studied with contemporary tools to elucidate their precise functional role in regulating motivated behaviors.

BEHAVIOURAL BRAIN RESEARCH (2021)

Article Psychiatry

Higher fasting ghrelin serum levels in active smokers than in former and never-smokers

Dirk Alexander Wittekind et al.

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2020)

Article Neurosciences

Dopamine Release Dynamics in the Tuberoinfundibular Dopamine System

Stefanos Stagkourakis et al.

JOURNAL OF NEUROSCIENCE (2019)

Review Psychology, Biological

Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder

Mehdi Farokhnia et al.

PHYSIOLOGY & BEHAVIOR (2019)

Review Substance Abuse

Stress, Motivation, and the Gut-Brain Axis: A Focus on the Ghrelin System and Alcohol Use Disorder

Laurel S. Morris et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2018)

Article Psychology, Biological

Changes in circulating peptide YY and ghrelin are associated with early smoking relapse

Andrine M. Lemieux et al.

BIOLOGICAL PSYCHOLOGY (2018)

Article Clinical Neurology

Desacylghrelin but not acylghrelin is reduced during smoking cessation

Mahsa Ardeshiripur et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

Review Biochemistry & Molecular Biology

Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

M. A. Lebow et al.

MOLECULAR PSYCHIATRY (2016)

Article Endocrinology & Metabolism

Effects of Cigarette Smoking on Plasma Concentration of the Appetite-Regulating Peptide Ghrelin

Anne Koopmann et al.

ANNALS OF NUTRITION AND METABOLISM (2015)

Article Endocrinology & Metabolism

Peptide YY and ghrelin predict craving and risk for relapse in abstinent smokers

Mustafa al'Absi et al.

PSYCHONEUROENDOCRINOLOGY (2014)

Review Neurosciences

The role of ghrelin in addiction: a review

Vassilis N. Panagopoulos et al.

PSYCHOPHARMACOLOGY (2014)

Article Endocrinology & Metabolism

Acute One-Cigarette Smoking Decreases Ghrelin Hormone in Saliva: A Pilot Study

Yahia A. Kaabi et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2014)

Article Biochemistry & Molecular Biology

Ghrelin and Nicotine Stimulate Equally the Dopamine Release in the Rat Amygdala

Miklos Palotai et al.

NEUROCHEMICAL RESEARCH (2013)

Article Biochemistry & Molecular Biology

Ghrelin amplifies the nicotine-induced dopamine release in the rat striatum

Miklos Palotai et al.

NEUROCHEMISTRY INTERNATIONAL (2013)

Article Biochemistry & Molecular Biology

Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving

Lorenzo Leggio et al.

ADDICTION BIOLOGY (2012)

Article Behavioral Sciences

Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol preference

Sara Landgren et al.

BEHAVIOURAL BRAIN RESEARCH (2011)

Article Psychology, Biological

Systemic ghrelin and reward: Effect of cholinergic blockade

E. Disse et al.

PHYSIOLOGY & BEHAVIOR (2011)

Review Endocrinology & Metabolism

Metabolic hormones, dopamine circuits, and feeding

Nandakumar S. Narayanan et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2010)

Review Neurosciences

Ghrelin in Central Neurons

F. Ferrini et al.

CURRENT NEUROPHARMACOLOGY (2009)

Article Multidisciplinary Sciences

Requirement of central ghrelin signaling for alcohol reward

Elisabet Jerlhag et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Neurosciences

The role of the dorsal striatum in reward and decision-making

Bernard W. Balleine et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Neurosciences

Increased leptin and decreased ghrelin level after smoking cessation

Heejin Lee et al.

NEUROSCIENCE LETTERS (2006)

Article Behavioral Sciences

Mediation of the behavioral, endocrine and thermoregulatory actions of ghrelin

M. Jaszberenyi et al.

HORMONES AND BEHAVIOR (2006)

Article Biochemistry & Molecular Biology

Locally administered low nicotine-induced neurotransmitter changes in areas of cognitive function

E Shearman et al.

NEUROCHEMICAL RESEARCH (2005)

Review Pharmacology & Pharmacy

Nicotine: from molecular mechanisms to behaviour

S Wonnacott et al.

CURRENT OPINION IN PHARMACOLOGY (2005)

Article Behavioral Sciences

Neurochemical and behavioral studies on ethanol and nicotine interactions

A Larsson et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2004)

Article Gastroenterology & Hepatology

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

A Asakawa et al.

GASTROENTEROLOGY (2001)