Interaction Between Blood Vasculatures and Lymphatic Vasculatures During Inflammation

Physiological activity cannot be regulated without the blood and lymphatic vasculatures, which play complementary roles in maintaining the body's homeostasis and immune responses. Inflammation is the body's initial response to pathological injury and is responsible for protecting the body, removing damaged tissues, and restoring and maintaining homeostasis in the body. A growing number of researches have shown that blood and lymphatic vessels play an essential role in a variety of inflammatory diseases. In the inflammatory state, the permeability of blood vessels and lymphatic vessels is altered, and angiogenesis and lymphangiogenesis subsequently occur. The blood vascular and lymphatic vascular systems interact to determine the development or resolution of inflammation. In this review, we discuss the changes that occur in the blood vascular and lymphatic vascular systems of several organs during inflammation, describe the different scenarios of angiogenesis and lymphangiogenesis at different sites of inflammation, and demonstrate the prospect of targeting the blood vasculature and lymphatic vasculature systems to limit the development of inflammation and promote the resolution of inflammation in inflammatory diseases.

Automated summary

Physiological activity depends on the blood and lymphatic vasculatures, which have complementary roles in maintaining homeostasis and immune responses. Inflammation is the initial response to injury and has important functions in protecting and restoring the body. Research has shown that blood and lymphatic vessels are crucial in various inflammatory diseases. Changes in the permeability of these vessels lead to angiogenesis and lymphangiogenesis during inflammation. The interaction between blood and lymphatic vessels determines the progression or resolution of inflammation. This review discusses the changes in these vascular systems during inflammation, the different scenarios of angiogenesis and lymphangiogenesis at different sites, and the potential of targeting these systems for inflammation therapy.