期刊
NATURE PROTOCOLS
卷 11, 期 9, 页码 1573-1578出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nprot.2016.104
关键词
-
资金
- Institute for Basic Science in South Korea [IBS-R021-D1]
- Ministry of Science, ICT & Future Planning, Republic of Korea [IBS-R021-D1-2016-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Genome editing harnesses programmable nucleases to cut and paste genetic information in a targeted manner in living cells and organisms. Here, I review the development of programmable nucleases, including zinc finger nucleases (ZFNs), TAL (transcription-activator-like) effector nucleases (TALENs) and CRISPR (cluster of regularly interspaced palindromic repeats)-Cas9 (CRISPR-associated protein 9) RNA-guided endonucleases (RGENs). I specifically highlight the key advances that set the foundation for the rapid and widespread implementation of CRISPR-Cas9 genome editing approaches that has revolutionized the field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据