☆ 4.8 Review

Haematopoietic cell-derived exosomes in cancer development and therapeutics: From basic science to clinical practice

CLINICAL AND TRANSLATIONAL MEDICINE (2023)

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Review Medicine, Research & Experimental

Engineered biomembrane-derived nanoparticles for nanoscale theranostics

Ziqing Wu et al.

Summary: Biological membrane engineering methods can enhance the functionality of biomembrane-derived nanoparticles for improved drug delivery and treatment. These methods can be applied to various biomembranes and are expected to play a significant role in the treatment and diagnosis of cancer, inflammation, immunological diseases, bone diseases, and Alzheimer's disease.

THERANOSTICS (2023)

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Article Cardiac & Cardiovascular Systems

Mechanism of Tumor-Platelet Communications in Cancer

Tejasvi Dudiki et al.

Summary: Thrombosis is a common complication in cancer patients and platelet hyperactivation plays a critical role. This study found that small extracellular vesicles (sEVs) released by cancer cells are efficiently taken up by platelets, leading to platelet activation and thrombosis. The discovery highlights the diagnostic and prognostic value of platelet-associated cancer markers and identifies new pathways for intervention.

CIRCULATION RESEARCH (2023)

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Article Medicine, Research & Experimental

M1 polarization enhances the antitumor activity of chimeric antigen receptor macrophages in solid tumors

Yi Huo et al.

Summary: This study developed a novel HER2-targeting CAR-M and demonstrated that M1 polarization enhanced the immune activity of CAR-M, resulting in effective elimination of HER2-positive tumor cells both in vitro and in vivo. This finding suggests that M1-polarized CAR-M has the potential to become a stronger therapeutic approach in solid cancer immunotherapy.

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

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Article Oncology

M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance

Naisheng Zheng et al.

Summary: M2-like tumor-associated macrophages undermine immune checkpoint blockade therapy by secreting exosomes that decrease tumor immunogenicity through downregulating MHC-I expression. Sensitizing therapy efficacy can be achieved by enhancing ATPase activity of BiP using ApoE ligand EZ-482 to boost tumor immunogenicity. Therefore, ApoE may serve as a predictive factor and potential therapeutic target for ICB resistance in M2-enriched cancer patients.

ONCOIMMUNOLOGY (2023)

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Article Oncology

Macrophage-inherited exosome excise tumor immunosuppression to expedite immune-activated ferroptosis

Duo Wang et al.

Summary: In this study, exosomes derived from M1 macrophages were engineered to deliver RSL3 and induce ferroptosis in tumor cells, activating immune responses and mitigating the immunosuppressive tumor microenvironment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2023)

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Article Engineering, Biomedical

M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator

Yili Wang et al.

Summary: Diabetes mellitus predisposes to delayed fracture healing due to chronic inflammation. Macrophages polarization into M1 or M2 subtypes plays a crucial role in fracture healing with pro- or anti-inflammatory functions. M2-exosomes, with low immunogenicity and high bioactivity, were extracted in this study and used to intervene diabetic fracture healing. The results showed that M2-exosomes modulate the osteoimmune microenvironment by reducing M1 macrophages proportion, thus accelerating diabetic fracture healing. It was further confirmed that M2-exosomes induce M1 to M2 macrophage conversion through the PI3K/AKT pathway. This study provides a fresh perspective and potential therapeutic approach for M2-exosomes in improving diabetic fracture healing.

BIOACTIVE MATERIALS (2023)

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Review Oncology

Therapeutic targeting of tumour myeloid cells

Simon T. Barry et al.

Summary: Myeloid cells in the tumour microenvironment have a significant impact on tumour progression, making them a key target for clinical therapies. However, large-scale clinical trials targeting these cells have had limited success. Understanding the specific functions and roles of different myeloid cell subpopulations within the tumour microenvironment could improve the design of successful clinical trials for myeloid-targeting therapies.

NATURE REVIEWS CANCER (2023)

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Article Oncology

Exosomes from M1-polarized macrophages promote apoptosis in lung adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis

Xuan Wang et al.

Summary: This study demonstrates that high expression of STK16 is associated with poor prognosis in lung adenocarcinoma (LUAD). Exosomes derived from M1 macrophages inhibit cell proliferation and promote apoptosis in LUAD cells by targeting STK16. The miR-181a-5p/ETS1/STK16 axis is identified as the underlying mechanism.

CANCER SCIENCE (2022)

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Article Immunology

alpha-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease

Zongran Liu et al.

Summary: This study found that alpha-synuclein derived from red blood cells mediates the sensitization of peripheral monocytes in patients with Parkinson's disease. This process leads to increased inflammatory activity in monocytes.

JOURNAL OF NEUROINFLAMMATION (2022)

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Article Medicine, Research & Experimental

microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82

Li Song et al.

Summary: This study reveals that miR-155-3p-enriched exosomes derived from M2 macrophages enhance the growth of medulloblastoma cells by down-regulating WDR82.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Article Multidisciplinary Sciences

Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy

Jiahui Zhang et al.

Summary: In this study, it was found that neutrophil-derived exosomes (N-Ex) can induce tumor cell apoptosis by delivering cytotoxic proteins and activating caspase signaling pathway. By decorating N-Ex with superparamagnetic iron oxide nanoparticles (SPIONs), a higher tumor-targeting therapeutic effect can be achieved. Moreover, exosome-like nanovesicles (NNVs) were fabricated with high yield. Compared to liposome-loaded doxorubicin (DOX) and natural NNVs, DOX-loaded NNVs showed improved inhibition of tumor cell proliferation. Additionally, DOX-loaded, SPION-decorated NNVs selectively accumulated at tumor sites under an external magnetic field, effectively restraining tumor growth and significantly prolonging survival rate in mice.

SCIENCE ADVANCES (2022)

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Article Biotechnology & Applied Microbiology

Cytokine-enhanced cytolytic activity of exosomes from NK Cells

Yutaka Enomoto et al.

Summary: NK-EVs derived from IL-15 + IL-21 stimulated NK-92 cells show enhanced cytotoxic capacity against tumor cells, with CD226 playing a key role. However, enrichment of cytolytic granules granzyme B and granzyme H is not the key factor contributing to the enhanced cytotoxic activity.

CANCER GENE THERAPY (2022)

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Review Oncology

CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy

Kevin Pan et al.

Summary: CAR immunotherapy has achieved significant progress in hematological malignancies, but faces challenges in solid tumors. CAR NK cells and CAR macrophages have advantages and limitations. Developing CAR macrophages could be a strategy to overcome hurdles associated with CAR therapy in solid tumors.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Biotechnology & Applied Microbiology

Therapeutically harnessing extracellular vesicles

Lesley Cheng et al.

Summary: The field of extracellular vesicle (EV) research has rapidly developed and is now recognized for its potential in the treatment and diagnosis of diseases. This article provides an overview of the characteristics and physiological functions of EVs, their association with diseases, and the strategies for their therapeutic exploitation.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Biochemistry & Molecular Biology

Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness and metabolism in lung cancer metastasis

Abhishek Tyagi et al.

Summary: Smoking is associated with increased risk of lung cancer brain metastasis. Chronic nicotine exposure recruits specific cells, secretes specific genes, and enhances the metastatic capacity of tumor cells in the brain.

ONCOGENE (2022)

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Article Cell Biology

M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway

Huaili Jiang et al.

Summary: This study revealed that M1-derived exosomes containing HOTTIP activate the TLR5/NF-kappa B signaling pathway by competitively sponging miR-19a-3p and miR-19b-3p, thereby suppressing the progression of head and neck squamous cell carcinoma (HNSCC). Additionally, M1-derived exosomes and HOTTIP induce the polarization of circulating monocytes towards an M1 phenotype, providing new insights into HNSCC immunotherapy.

CELL DEATH & DISEASE (2022)

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Article Biochemistry & Molecular Biology

Effect of platelet exosomes loaded with doxorubicin as a targeted therapy on triple-negative breast cancer cells

Dilara Uslu et al.

Summary: Exosomes loaded with doxorubicin isolated from human platelets were found to have a high encapsulation efficiency and suppressed the proliferation of breast cancer cells.

MOLECULAR DIVERSITY (2022)

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Article Cell Biology

Human platelet lysate-derived extracellular vesicles enhance angiogenesis through miR-126

Antonella Bordin et al.

Summary: Platelet lysate (PL) contains a subset of small vesicles with angiogenic effects, enriched with miR-126. These extracellular vesicles (EVs) play a key role in promoting angiogenic tubular structures in endothelial cells, representing a potential target for developing a product solely made of EVs for biological manipulation.

CELL PROLIFERATION (2022)

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Review Oncology

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Mahshid Deldar Abad Paskeh et al.

Summary: This review discusses the role of exosomes in cancer progression, therapy, and regulation of the tumor microenvironment. The study found that exosomes can influence cancer cell proliferation and migration rates by modulating components of the tumor microenvironment. Depending on their cargo, exosomes can promote or suppress tumor cell progression and enhance or reduce the response to radiotherapy and chemotherapy. Additionally, exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by transferring RNA and modulating molecular signaling pathways. Moreover, exosomes can serve as carriers of anti-tumor agents and genetic tools to control cancer progression. Finally, exosomes are valuable diagnostic and prognostic tools in the treatment of cancer patients.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Cell Biology

Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions

Mauro Vismara et al.

Summary: During hemostasis, thrombosis, and inflammation, activated blood platelets release extracellular vesicles (PEVs) that represent biological mediators of physiological and pathological processes. We have recently demonstrated that the activation of platelets by breast cancer cells is accompanied by a massive release of PEVs, evidence that matches with the observation that breast cancer patients display increased levels of circulating PEVs. Our study compared the PEVs released by platelets upon activation with thrombin and exposure to breast cancer cells, and found that the two populations of PEVs have different protein compositions and elicit different biological responses in target cells.

CELL DEATH DISCOVERY (2022)

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Article Biotechnology & Applied Microbiology

Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer

Yongmei Zhao et al.

Summary: Loading DTX into M1 macrophage-derived exosomes can achieve long-term activation of M1 macrophages in the immunosuppressive tumor microenvironment, leading to improved anti-tumor therapeutic efficacy.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Cell Biology

Activated Platelets and Platelet-Derived Extracellular Vesicles Mediate COVID-19-Associated Immunothrombosis

Marie Ebeyer-Masotta et al.

Summary: Activated platelets and platelet-derived extracellular vesicles play central roles in thromboembolic complications associated with severe COVID-19, but dysregulated platelet activation can lead to immunothrombosis. Activated platelets stimulate neutrophil activation through the release of mediators, resulting in abnormal activation of inflammation and coagulation processes.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions

Alaa Alnefaie et al.

Summary: Adaptive immunity plays a crucial role in protecting the body and can be enhanced to fight against cancer. CAR T-cell therapy, a pioneering technology in cancer treatment, has shown promising results in clinical trials. However, there are obstacles that limit its use as the first line of defense against cancer. Innovative CAR-T cell designs and proposed solutions have demonstrated significant potential for development.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Immunology

Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells

Tarun Tyagi et al.

Summary: This study reveals the immunosuppressive role of platelets in tumor growth and identifies the platelet protein TLT-1 as a key player in suppressing CD8 T cells. Anti-TLT-1 antibody shows potential as a therapeutic option to rescue T cell function and reduce tumor size. Clinically, higher TLT-1 levels are associated with reduced survival in non-small cell lung cancer patients.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

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Article Multidisciplinary Sciences

Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases

Tao Wan et al.

Summary: CRISPR-Cas9 gene editing is a powerful therapeutic technology, but the lack of safe and efficient in vivo delivery systems limits its clinical applications. Researchers have developed a novel gene editing delivery system, called exosomeRNP, which loads Cas9 RNPs into purified exosomes derived from hepatic stellate cells. exosomeRNP enables effective cytosolic delivery of RNPs in vitro and specifically accumulates in liver tissue in vivo. By targeting different genes, exosomeRNP demonstrates considerable therapeutic potential in acute liver injury, chronic liver fibrosis, and hepatocellular carcinoma mouse models. This study provides a feasible platform for precise and tissue-specific gene therapies for liver diseases.

SCIENCE ADVANCES (2022)

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Review Medicine, General & Internal

Pathophysiology of Coagulation and Emerging Roles for Extracellular Vesicles in Coagulation Cascades and Disorders

Houssam Al-Koussa et al.

Summary: Blood coagulation is a complex physiological process involving the activation of coagulation factors and intercellular communication. Imbalance in coagulation can lead to bleeding or thrombosis, and extracellular vesicles (EVs) may represent valuable approaches for the treatment and diagnosis of thrombotic diseases.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer

Jong Hyun Kim et al.

Summary: Intensive research in cancer biology has revealed unique methods of communication between cells using extracellular vesicles called exosomes. Blocking the release of exosomes may slow down cancer progression. Efforts are being made to develop exosome inhibitors for research and clinical trials.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

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Review Oncology

Translational advances in pancreatic ductal adenocarcinoma therapy

Abdel Nasser Hosein et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that is often diagnosed at advanced stages, leading to limited treatment options. Recent advancements in targeted therapy and immunotherapy for different subtypes of PDAC are reviewed in this article, with a focus on the current preclinical and clinical evidence supporting these approaches and the potential of combination treatments.

NATURE CANCER (2022)

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Review Oncology

Side-effect management of chimeric antigen receptor (CAR) T-cell therapy

M-L Schubert et al.

Summary: CAR T-cell therapy targeting CD19-expressing B cells has shown promising results in treating refractory and/or relapsed B-cell malignancies, but also presents challenges such as cytokine release syndrome and neurotoxicity syndrome. Optimal management strategies for the side-effects associated with CAR T-cell therapy are crucial as it expands into other diseases in hematology and oncology.

ANNALS OF ONCOLOGY (2021)

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Editorial Material Cell Biology

M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway

Jian Pu et al.

Summary: This study revealed that M2 macrophage-derived extracellular vesicles facilitated CD8(+) T cell exhaustion in HCC patients through the miR-21-5p/YOD1/YAP/beta-catenin axis. Inhibition of miR-21-5p or overexpression of YOD1 could annul the promoting effect of EVs on CD8(+) T cell exhaustion.

CELL DEATH DISCOVERY (2021)

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Article Oncology

Liquid biopsy enters the clinic - implementation issues and future challenges

Michail Ignatiadis et al.

Summary: The approval of liquid biopsy assays for detecting genetic alterations in plasma cell-free DNA has marked a tipping point for the clinical use of this technology, especially in patients with advanced-stage cancer. The next frontier is likely to be the systemic treatment of patients with 'ctDNA relapse' and other potential future applications include cancer screening and diagnosis.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Oncology

Critical immunosuppressive effect of MDSC-derived exosomes in the tumor microenvironment

Mohammad H. Rashid et al.

Summary: MDSC-derived exosomes carry proteins that play a crucial role in tumor growth, invasion, angiogenesis, and immunomodulation. They are capable of hyper-activating or exhausting CD8 T-cells and inducing activation-induced cell death. In vivo experiments showed a depletion of CD8 T-cells and a reduction in pro-inflammatory M1-macrophages in the spleen after treatment with MDSC exosomes.

ONCOLOGY REPORTS (2021)

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Article Cell Biology

The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth

Pengxiang Yang et al.

Summary: Exosomes derived from CAR-T cells targeting MSLN showed potential in inhibiting the growth of MSLN-positive triple-negative breast cancer cells, with characteristics similar to parental T cells. The expression of effector molecules may contribute to tumor killing, and in vivo studies demonstrated a highly effective tumor inhibition rate with no obvious side effects. The use of CAR-T cell exosomes has promising therapeutic potential against MSLN-expressing TNBC.

CELLULAR IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Immunotherapy Strategy Targeting Programmed Cell Death Ligand 1 and CD73 with Macrophage-Derived Mimetic Nanovesicles to Treat Bladder Cancer

Qidong Zhou et al.

Summary: The use of EMVs as a nanoplatform for delivering a combination of CD73 inhibitor and aPDL1 monoclonal antibody showed promising results in improving therapeutic effects for bladder cancer.

MOLECULAR PHARMACEUTICS (2021)

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Article Biotechnology & Applied Microbiology

M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2

Yuhan Yang et al.

Summary: The study revealed that exosomes derived from M2 macrophages can promote angiogenesis in PDAC, leading to accelerated tumor growth. By transferring miR-155-5p and miR-221-5p to endothelial cells, the interaction between TAMs and angiogenesis in PDAC was further confirmed. Targeting exosomal miRNAs from TAMs may provide diagnostic and therapeutic strategies for PDAC.

MOLECULAR THERAPY (2021)

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Article Cell Biology

Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment

Shuang Wang et al.

Summary: A novel approach using macrophage-tumor hybrid cells to produce chimeric exosomes that can accumulate in lymph nodes and various tumors, demonstrating effectiveness in inducing tumor regression and improving survival in mouse models. Combination with anti-programmed death 1 (a-PD1) treatment further extends survival in metastatic and postsurgical tumor recurrence models, highlighting potential for personalized immunotherapy.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Review Cell Biology

Extracellular vesicles and immunogenic stress in cancer

Qi Wu et al.

Summary: Tumor progression relies on bidirectional cell-to-cell communication within a complex tumor microenvironment, with extracellular vesicles playing a crucial role as carriers. The concept of immunogenic stress suggests that cancer cells can release EVs containing specific immunoregulatory mediators in stressed microenvironments, leading to changes in immune status in the TME.

CELL DEATH & DISEASE (2021)

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Article Chemistry, Multidisciplinary

On-Chip Biogenesis of Circulating NK Cell-Derived Exosomes in Non-Small Cell Lung Cancer Exhibits Antitumoral Activity

Yoon-Tae Kang et al.

Summary: NK cells and their derived exosomes play a crucial role in cancer immunotherapy, as they exhibit high stability and lower immunogenicity, providing possibilities for personalized treatments. A novel microfluidic system for collecting patient-specific NK cells and NK-exosomes on chips offers potential applications in cancer therapies.

ADVANCED SCIENCE (2021)

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Article Oncology

M2 macrophage-derived exosomal microRNA-155-5p promotes the immune escape of colon cancer by downregulating ZC3H12B

Yu-Shui Ma et al.

Summary: The study investigates the role of M2 macrophage-derived exosomal miR-155-5p in immune escape of colon cancer cells. They found that miR-155-5p could be transferred to cancer cells, targeting ZC3H12B and promoting proliferation and antiapoptosis abilities. Additionally, the miRNA reduced ZC3H12B-mediated IL-6 stability, leading to immune escape and tumor formation.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Oncology

Exosomal HMGB1 Promoted Cancer Malignancy

Jiaan-Der Wang et al.

Summary: The interaction between platelets and cancer cells suggest that antiplatelet drugs may play a role in inhibiting cancer cell growth and malignancy.

CANCERS (2021)

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Article Cell Biology

Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery

Tin Chanh Pham et al.

Summary: The study presents a novel method for covalently conjugating EVs with targeting moieties using protein ligases, enabling specific delivery of therapeutic payloads to target cells without the need for genetic and chemical modifications. This approach shows promise for enhancing drug efficacy in cancer therapy by targeting specific receptors on cancer cells.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Nanoscience & Nanotechnology

Engineering Exosomes Endowed with Targeted Delivery of Triptolide for Malignant Melanoma Therapy

Liangdi Jiang et al.

Summary: The study proposes a delivery system based on TRAIL-engineered exosomes (TRAIL-Exo) for loading TPL for targeted therapy against malignant melanoma, which improves tumor targetability, enhances cellular uptake, inhibits proliferation, invasion, and migration, and induces apoptosis of A375 cells through activating the extrinsic TRAIL pathway and the intrinsic mitochondrial pathway in vitro. Intravenous injection of TRAIL-Exo/TPL significantly suppresses tumor progression and reduces the toxicity of TPL in the melanoma nude mouse model, presenting a novel strategy for high-efficiency exosome-based drug-delivery nanocarriers with synergistic therapeutic efficacy and targeting capacity for melanoma treatment.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Nanocomplex-Mediated In Vivo Programming to Chimeric Antigen Receptor-M1 Macrophages for Cancer Therapy

Mikyung Kang et al.

Summary: The study proposes a simple method to transform macrophages that can naturally infiltrate solid tumors into CAR-M1 macrophages with enhanced cancer-directed phagocytosis and anti-tumor activity. Injected nanocomplexes of macrophage-targeting nanocarriers and CAR-interferon-gamma-encoding plasmid DNA induce CAR-M1 macrophages capable of CAR-mediated cancer phagocytosis, tumor immunomodulation, and inhibiting solid tumor growth, providing an effective off-the-shelf CAR-macrophage therapy for solid tumors without the need for complex and costly ex vivo CAR-cell manufacturing processes.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

Jun Wang et al.

Summary: NEs-Exos system exhibits neutrophil-like chemotactic function and BBB penetration capability, efficiently suppressing tumor growth and prolonging survival time in a glioma mouse model.

BIOMATERIALS (2021)

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Review Immunology

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Filippo Veglia et al.

Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

CD45RO(-)CD8(+) T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ER beta/miR-765/PLP2/Notch axis

Wen-Jie Zhou et al.

Summary: The study investigated the molecular mechanisms underlying the interaction between estrogen signaling and CD8(+) T cells, and identified the regulatory value of the ER beta/miR-765/PLP2/Notch signaling axis in uterine corpus endometrial cancer.

THERANOSTICS (2021)

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Article Immunology

An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes in vitro

Mareike Ohms et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Human chimeric antigen receptor macrophages for cancer immunotherapy

Michael Klichinsky et al.

NATURE BIOTECHNOLOGY (2020)

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Review Pharmacology & Pharmacy

Macrophage M1/M2 polarization

Chen Yunna et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Cell Biology

Anticancer effects of miR-124 delivered by BM-MSC derived exosomes on cell proliferation, epithelial mesenchymal transition, and chemotherapy sensitivity of pancreatic cancer cells

Yan Xu et al.

AGING-US (2020)

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Article Biotechnology & Applied Microbiology

G-MDSCs-Derived Exosomal miRNA-143-3p Promotes Proliferation via Targeting of ITM2B in Lung Cancer

Jian-hua Zhou et al.

ONCOTARGETS AND THERAPY (2020)

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Article Medicine, Research & Experimental

M2 Macrophage-Derived Exosomal lncRNA AFAP1-AS1 and MicroRNA-26a Affect Cell Migration and Metastasis in Esophageal Cancer

Xifeng Mi et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Cell Biology

Extracellular vesicles: Natural liver-accumulating drug delivery vehicles for the treatment of liver diseases

Gensheng Zhang et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Cell Biology

Exosomal miRNA-16-5p Derived From M1 Macrophages Enhances T Cell-Dependent Immune Response by Regulating PD-L1 in Gastric Cancer

Zhengtian Li et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Proteome Analysis of Human Natural Killer Cell Derived Extracellular Vesicles for Identification of Anticancer Effectors

Jung-Won Choi et al.

MOLECULES (2020)

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Letter Oncology

Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions

Li Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Biochemistry & Molecular Biology

Application of exosomes as liquid biopsy in clinical diagnosis

Biting Zhou et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Genetics & Heredity

Exosomes derived from exhausted CD8+T cells impaired the anticancer function of normal CD8+T cells

Xiaochen Wang et al.

JOURNAL OF MEDICAL GENETICS (2019)

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Article Oncology

Exosomes derived from human umbilical cord mesenchymal stromal cells deliver exogenous miR-145-5p to inhibit pancreatic ductal adenocarcinoma progression

Yixuan Ding et al.

CANCER LETTERS (2019)

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Article Immunology

Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses

Fanghui Zhang et al.

IMMUNITY (2019)

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Article Critical Care Medicine

Regulation of endothelial cell permeability by platelet-derived extracellular vesicles

Byron Miyazawa et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2019)

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Article Oncology

Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway

Zi Yin et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Cell Biology

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles

Chiara Cianciaruso et al.

CELL REPORTS (2019)

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Article Chemistry, Multidisciplinary

Granulocytic Myeloid-Derived Suppressor Cells Promote the Stemness of Colorectal Cancer Cells through Exosomal S100A9

Yungang Wang et al.

ADVANCED SCIENCE (2019)

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Article Multidisciplinary Sciences

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

Wenyan Fu et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms

Paolo Neviani et al.

CANCER RESEARCH (2019)

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Article Oncology

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

Jingqin Lan et al.

CANCER RESEARCH (2019)

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Article Immunology

Natural Killer Cell-Derived Exosomal miR-3607-3p Inhibits Pancreatic Cancer Progression by Targeting IL-26

Hongwei Sun et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Medicine, Research & Experimental

Exosomes from M1-Polarized Macrophages Enhance Paclitaxel Antitumor Activity by Activating Macrophages-Mediated Inflammation

Piaopiao Wang et al.

THERANOSTICS (2019)

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Letter Medicine, General & Internal

Chimeric Antigen Receptor-Natural Killer Cells: The Future of Cancer Immunotherapy

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OCHSNER JOURNAL (2019)

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Article Cell Biology

Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells

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JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Remote-Loaded Platelet Vesicles for Disease-Targeted Delivery of Therapeutics

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ADVANCED FUNCTIONAL MATERIALS (2018)

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A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

Scott W. Messenger et al.

JOURNAL OF CELL BIOLOGY (2018)

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Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

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NATURE COMMUNICATIONS (2018)

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Efficient RNA drug delivery using red blood cell extracellular vesicles

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NATURE COMMUNICATIONS (2018)

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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

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NATURE (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

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JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Biochemistry & Molecular Biology

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis

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ONCOGENE (2017)

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Article Oncology

NK Cell-derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells

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JOURNAL OF IMMUNOTHERAPY (2017)

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Article Biotechnology & Applied Microbiology

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

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MOLECULAR THERAPY (2017)

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Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Sushrut Kamerkar et al.

NATURE (2017)

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Article Hematology

Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response

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THROMBOSIS RESEARCH (2017)

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Article Multidisciplinary Sciences

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

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NATURE COMMUNICATIONS (2017)

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Exosomes Derived From Natural Killer Cells Exert Therapeutic Effect in Melanoma

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THERANOSTICS (2017)

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Review Immunology

Potentiation of Natural Killer Cells for Cancer Immunotherapy: A Review of Literature

Lacy E. Lowry et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Hematology

Platelet interaction with activated endothelium: mechanistic insights from microfluidics

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BLOOD (2017)

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Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells

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CANCER LETTERS (2017)

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Review Cardiac & Cardiovascular Systems

Extracellular Vesicles in Angiogenesis

Dilyana Todorova et al.

CIRCULATION RESEARCH (2017)

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Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

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ONCOIMMUNOLOGY (2016)

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ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

Carolina Villarroya-Beltri et al.

NATURE COMMUNICATIONS (2016)

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Anticancer Platelet-Mimicking Nanovehicles

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ADVANCED MATERIALS (2015)

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Heparanase activates the syndecan-syntenin-ALIX exosome pathway

Bart Roucourt et al.

CELL RESEARCH (2015)

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Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro

Ali Danesh et al.

BLOOD (2014)

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Article Immunology

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

Isobel S. Okoye et al.

IMMUNITY (2014)

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Article Biochemical Research Methods

Exosomes from Myeloid-Derived Suppressor Cells Carry Biologically Active Proteins

Meghan Burke et al.

JOURNAL OF PROTEOME RESEARCH (2014)

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Human B cell-derivec ymphoblastoid cell I nes constitutively produce Fas ligand and secrete MHCII+FasL+ killer exosomes

Matthew W. Klinker et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Oncology

Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases

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BIOMARKER RESEARCH (2014)

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Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

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ACS NANO (2013)

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Article Biochemistry & Molecular Biology

Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles

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CELL (2013)

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Review Cell Biology

The incredible journey: From megakaryocyte development to platelet formation

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JOURNAL OF CELL BIOLOGY (2013)

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Minimal Self Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

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SCIENCE (2013)

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Review Immunology

Epigenetic regulation of macrophage polarization and function

Lionel B. Ivashkiv

TRENDS IN IMMUNOLOGY (2013)

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Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes

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JOURNAL OF EXTRACELLULAR VESICLES (2013)

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Hypoxic enhancement of exosome release by breast cancer cells

Hamish W. King et al.

BMC CANCER (2012)

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Circulating Microparticles as Disease-Specific Biomarkers of Severity of Inflammation in Patients With Hepatitis C or Nonalcoholic Steatohepatitis

Miroslaw Kornek et al.

GASTROENTEROLOGY (2012)

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Article Immunology

Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway

Zhijian Cai et al.

JOURNAL OF IMMUNOLOGY (2012)

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Syndecan-syntenin-ALIX regulates the biogenesis of exosomes

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NATURE CELL BIOLOGY (2012)

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Paraneoplastic Thrombocytosis in Ovarian Cancer

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NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Immunology

CD4(+) T cell-released exosomes inhibit CD8(+) cytotoxic T-lymphocyte responses and antitumor immunity

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CELLULAR & MOLECULAR IMMUNOLOGY (2011)

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Review Cell Biology

The ESCRT Pathway

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DEVELOPMENTAL CELL (2011)

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Article Biochemistry & Molecular Biology

Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation

Kevin Carayon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Article Immunology

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

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JOURNAL OF IMMUNOLOGY (2011)

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Contribution of platelets to tumour metastasis

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NATURE REVIEWS CANCER (2011)

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Review Immunology

Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors

Motonari Kondo

IMMUNOLOGICAL REVIEWS (2010)

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Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C

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JOURNAL OF CELL BIOLOGY (2010)

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Article Oncology

Thrombin Regulates the Metastatic Potential of Human Rhabdomyosarcoma Cells: Distinct Role of PAR1 and PAR3 Signaling

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MOLECULAR CANCER RESEARCH (2010)

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Article Nanoscience & Nanotechnology

Homologous RBC-derived vesicles as ultrasmall carriers of iron oxide for magnetic resonance imaging of stem cells

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NANOTECHNOLOGY (2010)

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Article Cell Biology

Rab27a and Rab27b control different steps of the exosome secretion pathway

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NATURE CELL BIOLOGY (2010)

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Peripheral cytokines profile in Parkinson's disease

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BRAIN BEHAVIOR AND IMMUNITY (2009)

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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: N1 versus N2 TAN

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CANCER CELL (2009)

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Article Immunology

Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor

Sarah C. Saunderson et al.

JOURNAL OF IMMUNOLOGY (2008)

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Ceramide triggers budding of exosome vesicles into multivesicular Endosomes

Katarina Trajkovic et al.

SCIENCE (2008)

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T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes

Aura Muntasell et al.

EMBO JOURNAL (2007)

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Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction

Marcela Helena Gambim et al.

CRITICAL CARE (2007)

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Article Hematology

Enhancing effect of platelet-derived microvesicles on the invasive potential of breast cancer cells

Anna Janowska-Wieczorek et al.

TRANSFUSION (2006)

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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes:: results of thefirst phase I clinical trial

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JOURNAL OF TRANSLATIONAL MEDICINE (2005)

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Article Medicine, Research & Experimental

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

MA Morse et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2005)

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Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer

A Janowska-Wieczorek et al.

INTERNATIONAL JOURNAL OF CANCER (2005)

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Role of LBPA and Alix in multivesicular liposome formation and endosome organization

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SCIENCE (2004)

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Article Biochemistry & Molecular Biology

Exosome release is regulated by a calcium-dependent mechanism in K562 cells

A Savina et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Hematology

Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells

M Baj-Krzyworzeka et al.

EXPERIMENTAL HEMATOLOGY (2002)

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Article Immunology

TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex

N Blanchard et al.

JOURNAL OF IMMUNOLOGY (2002)

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Article Hematology

Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment

A Janowska-Wieczorek et al.

BLOOD (2001)

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