Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

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pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

Yongping Liang et al.

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ACS NANO (2022)

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Article Engineering, Biomedical

Polymeric coating on β-TCP scaffolds provides immobilization of small extracellular vesicles with surface-functionalization and ZEB1-Loading for bone defect repair in diabetes mellitus

Shi-Cong Tao et al.

Summary: Repair of critical-size bone defects in patients with diabetes mellitus (DM) is a clinical challenge. In this study, a new strategy was developed to promote bone defect regeneration in DM conditions by immobilizing sEVs on scaffolds. The results demonstrated that this strategy enhanced angiogenesis, promoted osteogenesis, and inhibited osteoclast formation, effectively promoting the repair of diabetic bone defects.

BIOMATERIALS (2022)

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The living interface between synthetic biology and biomaterial design

Allen P. Liu et al.

Summary: Recent advancements in synthetic biology and biomaterials have provided exciting tools for creating new materials and extending the application of synthetic biology. Despite their transformative potential, these fields have mostly progressed separately. This Perspective reviews recent key advances and presents a roadmap for collaboration between the two communities, emphasizing the near-term applications in developing hierarchically structured biomaterials.

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In situ 3D bioprinting with bioconcrete bioink

Mingjun Xie et al.

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NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Strontium Substituted β-Tricalcium Phosphate Ceramics: Physiochemical Properties and Cytocompatibility

Inna Fadeeva et al.

Summary: In this study, Sr2+-substituted beta-tricalcium phosphate ceramics were synthesized and their physicochemical properties and biocompatibility were investigated. The results showed that the introduction of Sr2+ ions significantly improved cell adhesion, proliferation, and cytocompatibility of the samples.

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Article Biotechnology & Applied Microbiology

3D-printed mesoporous bioactive glass/GelMA biomimetic scaffolds for osteogenic/cementogenic differentiation of periodontal ligament cells

Nianrou Mei et al.

Summary: The integration of 3D printed GelMA-based scaffolds with mesoporous bioactive glass nanoparticles improves the structural stability and promotes the regeneration of periodontal tissues.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc

Sheng Chen et al.

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Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis

Arpeeta Sharma et al.

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DIABETES (2021)

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Review Biochemistry & Molecular Biology

Biomineralization of Collagen-Based Materials for Hard Tissue Repair

Le Yu et al.

Summary: This review discusses the mineralization of collagen fibrils into hydroxyapatite, dividing it into intrafibrillar and extrafibrillar mineralization. Various mechanisms and strategies for inducing biomimetic intrafibrillar mineralization are examined, along with applications for bone regeneration and dentin repair using mineralized collagen fibers. Potential future trends in collagen-based materials for bone and tooth repair are also speculated.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries

Lihua Luo et al.

Summary: By optimizing the scaffold material synthesis protocol, a third-generation nerve regeneration conduit CSM-GFD was constructed and applied for repairing a 15-mm long defect of the sciatic nerve in a rat model. At histologic and physical levels, the conduit regenerated nerve tissue and achieved functional recovery, showing promising potential as a tissue engineering approach for treating large gap defects in peripheral nerve injuries.

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Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus

Xin Sun et al.

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BIOACTIVE MATERIALS (2021)

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Parathyroid Hormone 1 Receptor Signaling in Dental Mesenchymal Stem Cells: Basic and Clinical Implications

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Review Engineering, Biomedical

Immunomodulatory bioactive glasses for tissue regeneration

Kai Zheng et al.

Summary: The regulatory functions of immune response in tissue regeneration, ways to modulate immune cell responses (especially macrophages), and the potential of bioactive glasses in bone regeneration and wound healing have been recognized. Understanding the immunomodulatory effects of BGs and the interactions with immune cells are crucial for enhancing tissue regeneration. Emerging research focuses on harnessing macrophage responses through active ions, surface functionalization, and controlled release of immunomodulatory agents for improved tissue regeneration.

ACTA BIOMATERIALIA (2021)

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Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization

Xiaohan Dai et al.

Summary: By fabricating a biomimetic electrical microenvironment using a nanocomposite membrane, inflammation in diabetic conditions was inhibited, leading to enhanced bone regeneration through the promotion of M2 macrophage phenotype.

BIOACTIVE MATERIALS (2021)

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Advances of hydrogel dressings in diabetic wounds

Heni Wang et al.

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Porous bioactive glass micro- and nanospheres with controlled morphology: developments, properties and emerging biomedical applications

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Summary: Porous bioactive glass micro/nanospheres (PBGSs) have emerged as attractive biomaterials in biomedical applications, with controllable particle size and pore structure critical for their functionality. Sol-gel processing is the primary method used for PBGSs synthesis, allowing for control over the chemical compositions and pore structures. Recent progress has been made in the synthesis of PBGSs with sophisticated pore structures, and their achievements in bone tissue regeneration, wound healing, drug delivery, bioimaging, and cancer therapy have been highlighted.

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A Review of Phosphate and Borate Sol-Gel Glasses for Biomedical Applications

William C. Lepry et al.

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Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

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