期刊
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
卷 17, 期 1, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/16583655.2023.2244749
关键词
Rhodiola rosea; liver dysfunction; monosodium glutamate; apoptosis; antioxidant; Nrf2 and HO-1 expression
This study investigated the protective effects of R. rosea extract on hepatic toxicity caused by MSG, demonstrating that R. rosea extract can regulate inflammation, oxidative stress, and apoptosis-related markers to alleviate liver damage.
Current study examined the protective impact of Rhodiola rosea (R. rosea) extract on hepatic toxicity markers caused by MSG. MSG induced significant increases in hepatic stress biomarkers. There were significant declines in GSH, catalase and SOD levels, which were accompanied by substantial elevations in IL-1 beta, IL-6, and TNF-alpha. There was hepatic cellular damage, and upregulation of caspase-3 and a decrease in Bcl-2 expression. The hepatotoxic impacts of MSG were normalized by Rhodiola supplementation. R. rosea downregulated caspase-3 and upregulated HO-1 and Nrf2 mRNA expression. R. rosea regulated the immunoreactivity of COX-2, TGF-beta 1, and NFkB genes associated with hepatic toxicity. R. rosea extract normalized histopathological changes induced by MSG and restored hepatic architecture. R. rosea extract exhibited anti-apoptotic, antioxidant, and anti-inflammatory properties. In conclusion, R. rosea extract is a promising medication against hepatic toxicity induced by MSG, which works by regulating the different signaling pathways of inflammation-, oxidative-stress-, and apoptosis-associated markers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据