期刊
NATURE NEUROSCIENCE
卷 20, 期 2, 页码 287-296出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4458
关键词
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资金
- Formacion de Profesorado Universitario (FPU) grant by the Ministerio de Educacion y Ciencia, Spanish government
- Innovational Research Incentives Scheme grant of the Netherlands Organization for Scientific Research (NWO) [451-14-036]
- National Council of Science and Technology of Mexico
- Consejeria de Educacion, Juventud y Deporte of Comunidad de Madrid
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7)/under REA grant [291820]
- Agencia de Gestic d'Ajuts Universitaris de Recerca, Generalitat de Catalunya
Pregnancy involves radical hormone surges and biological adaptations. However, the effects of pregnancy on the human brain are virtually unknown. Here we show, using a prospective ('pre'-'post' pregnancy) study involving first-time mothers and fathers and nulliparous control groups, that pregnancy renders substantial changes in brain structure, primarily reductions in gray matter (GM) volume in regions subserving social cognition. The changes were selective for the mothers and highly consistent, correctly classifying all women as having undergone pregnancy or not in-between sessions. Interestingly, the volume reductions showed a substantial overlap with brain regions responding to the women's babies postpartum. Furthermore, the GM volume changes of pregnancy predicted measures of postpartum maternal attachment, suggestive of an adaptive process serving the transition into motherhood. Another follow-up session showed that the GM reductions endured for at least 2 years post-pregnancy. Our data provide the first evidence that pregnancy confers long-lasting changes in a woman's brain.
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