期刊
NATURE NEUROSCIENCE
卷 19, 期 2, 页码 198-205出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4220
关键词
-
资金
- Klarman Family Foundation
- Brain and Behavior Research Foundation
- Foundation for Prader-Willi Research
- Foundation of Hope
- National Institute on Drug Abuse [DA032750, DA038168]
- Department of Psychiatry at UNC Chapel Hill
- Intramural Research Program at the National Institute on Drug Abuse
In experiments conducted over 60 years ago, the lateral hypothalamic area (LHA) was identified as a critical neuroanatomical substrate for motivated behavior. Electrical stimulation of the LHA induces voracious feeding even in well-fed animals. In the absence of food, animals will work tirelessly, often lever-pressing thousands of times per hour, for electrical stimulation at the same site that provokes feeding, drinking and other species-typical motivated behaviors. Here we review the classic findings from electrical stimulation studies and integrate them with more recent work that has used contemporary circuit-based approaches to study the LHA. We identify specific anatomically and molecularly defined LHA elements that integrate diverse information arising from cortical, extended amygdala and basal forebrain networks to ultimately generate a highly specified and invigorated behavioral state conveyed via LHA projections to downstream reward and feeding-specific circuits.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据