期刊
NATURE NEUROSCIENCE
卷 19, 期 6, 页码 784-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4289
关键词
-
资金
- NIH [P40RR018604]
- Ray W. Poppleton Endowment
- [NINDS-NS083942]
Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.
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