期刊
NATURE NEUROSCIENCE
卷 19, 期 8, 页码 1093-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4337
关键词
-
资金
- Lieber Institute for Brain Development
- Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Education in Korea [NRF-2015R1D1A1A09057171]
- Johns Hopkins Bloomberg School of Public Health
RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity and recoding proteins. Here we surveyed the global landscape of RNA editing in human brain tissues and identified three unique patterns of A-to-I RNA editing rates during cortical development: stable high, stable low and increasing. RNA secondary structure and the temporal expression of adenosine deaminase acting on RNA (ADAR) contribute to cis- and trans-regulatory mechanisms of these RNA editing patterns, respectively. Interestingly, the increasing pattern was associated with neuronal maturation, correlated with mRNA abundance and potentially influenced miRNA binding energy. Gene ontology analyses implicated the increasing pattern in vesicle or organelle membrane-related genes and glutamate signaling pathways. We also found that the increasing pattern was selectively perturbed in spinal cord injury and glioblastoma. Our findings reveal global and dynamic aspects of RNA editing in brain, providing new insight into epitranscriptional regulation of sequence diversity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据