期刊
NATURE NEUROSCIENCE
卷 19, 期 3, 页码 420-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4228
关键词
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资金
- US National Institute of Mental Health (NIMH) [U01 MH094421]
- Netherlands Scientific Organization [NWO 480-05-003]
- Max Planck Society
- Max-Planck-Forderstiftung
- DFG Center for Nanoscale Microscopy AMP
- Molecular Physiology of the Brain (CNMPB), Gottingen, Germany
- NIMH [P50 MH080272, U01 MH081928, R01 MH092380, K99 MH101367, MH085548, MH085542, MH071681, MH061884, MH58693, MH52618, R01 MH083094, R01 MH041953, R01 MH068881]
- Massachusetts General Hospital Executive Committee on Research
- NCRR [RR026075]
- Department of Veterans Affairs Merit Review Program
- Lundbeck Foundation
- Danish Strategic Research Council
- Aarhus University
- Stanley Research Foundation
- UK Medical Research Council (MRC) Centre [G0800509]
- MRC Programme [G0801418]
- European Community's Seventh Framework Programme [HEALTH-F2-2010-241909]
- European Union Seventh Framework Programme (FP7) [279227]
- MRC/Welsh Assembly Government
- Margaret Temple Award from the British Medical Association
- Wellcome Trust [076113/C/04/Z, 076113/CI04/Z, 072894/Z/03/Z, 090532/Z/09/Z, 075491/Z/04/B, 068545/Z/02]
- National Institute for Health Research programme grant [RP-PG-0310-1002]
- WTCCC2 grant [WTCCC-084710]
- Janssen Research Foundation, Beerse, Belgium
- Netherlands Organization for Health Research and Development (ZonMw) in the Mental Health program
- Danish Council for Strategic Research [09-067048]
- Danish National Advanced Technology Foundation [001-2009-2]
- Lundbeck Foundation [R24-A3243]
- EU
- Wellcome Trust as part of the WTCCC2 project
- MRC
- Research Council of Norway [213837, 217776, 223273]
- South-East Norway Health Authority [2013-123]
- K. G. Jebsen Foundation
- Donald and Barbara Zucker Foundation
- North Shore - Long Island Jewish Health System Foundation
- Stanley Foundation
- NARSAD
- SynSys [EU FP7-242167]
- Sigrid Juselius Foundation
- Academy of Finland [251704]
- Sohlberg Foundation
- Swedish Research Council [2006-4472, 2009-5269, 2009-3413, 345-2003-3883, 315-2004-6977, 80576801, 70374401]
- County Council of Vasterbotten, Sweden
- County Council of Norrbotten, Sweden
- Bank of Sweden Tercentenary Foundation
- Swedish Council for Planning and Coordination of Research
- Swedish Council for Research in the Humanities and Social Sciences
- Swedish Council for Social Research
- Estonian Ministry of Science and Education [SF0180142s08]
- US National Institutes of Health (NIH) [R01 DK075787]
- University of Tartu [SP1GVARENG]
- European Regional Development Fund [3.2.0304.11-0312]
- FP7 grant [313010]
- Singapore National Medical Research Council [NMRC/TCR/003/2008]
- Singapore Biomedical Research Council
- Singapore Agency for Science, Technology and Research (A*STAR)
- Uppsala University, Uppsala University Hospital, Science for Life Laboratory
- Stockholm County Council
- Karolinska Insititutet
- Australian Schizophrenia Research Bank
- National Health and Medical Research Council [386500]
- Pratt Foundation
- Ramsay Health Care
- Viertel Charitable Foundation
- Schizophrenia Research Institute
- NSW Department of Health
- National Health and Medical Research Council (Australia)
- Australian National Health and Medical Research Council
- German Federal Ministry of Education and Research (BMBF) through the Integrated Genome Research Network MooDS under the National Genome Research Network plus (NGFNplus) [01GS08144, 01GS08147]
- Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under e:Med Programme (GlaxoSmithKline)
- Bavarian Ministry of Commerce
- BMBF [01GS0481]
- German Research Foundation (DFG)
- Alfried Krupp von Bohlen und Halbach-Stiftung
- European Union [279227, HEALTH-F4-2009-242257, HEALTH-2011-1.1-2]
- Stanley Medical Research Institute
- Stanley Center for Psychiatric Research
- Sylvan Herman Foundation
- Friedman Brain Institute at the Mount Sinai School of Medicine
- Karolinska Institutet, Karolinska University Hospital
- Swedish County Council
- Soderstrom Konigska Foundation
- Juvenile Diabetes Research Foundation [WT0618S8]
- National Institute of Health Research of England
- Walter E. Nichols, M. D., Professorship in the School of Medicine
- Eleanor Nichols Endowment
- Walter F. AMP
- Rachael L. Nichols Endowment
- William and Mary McIvor Endowment, Stanford University
- NIH [MH67257, MH59588, MH59571, MH59565, MH59587, MH60870, MH59566, MH59586, MH61675, MH60879, MH81800, MH46276, MH46289, MH46318, MH79469, MH79470, R01D0042157-01A, MH081802]
- Genetic Association Information Network (GAIN)
- Paul Michael Donovan Charitable Foundation
- National Center for Research Resources [U54 RR020278]
- WTCCC2 project [085475/B/08/Z, 085475/Z/08/Z]
- MRC [G0000934]
- Hong Kong Research Grants Council project [GRF 774707M, 777511M, 776412M, 776513M]
- NIH institutes contributing to the Big Data to Knowledge (BD2K) initiative [U54 EB020403]
- NIBIB
- NCI.ADNI
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (NIH) [U01 AG024904]
- US Department of Defense [W81XWH-12-2-0012]
- US National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Canadian Institutes of Health Research
- Northern California Institute for Research and Education
- Knut and Alice Wallenberg Foundation
- Torsten and Ragnar Soderbergs Foundation
- HelseVest RHF [911554]
- Scottish Mental Health Research Network
- National Alliance for Research on Schizophrenia and Depression (NARSAD) Independent Investigator Award
- Health Foundation Clinician Scientist Fellowship
- Biobanking and Biomolecular Resources Research Infrastructure (Netherlands) (BBMRI-NL)
- Hersenstichting Nederland
- Netherlands Organization for Scientific Research (NWO)
- European Community [602450, 602805]
- Vici grant from the NWO [016.130.669]
- Center for Brain Science Neuroinformatics Research Group
- Athinoula A. Martinos Center for Biomedical Imaging
- Center for Human Genetic Research
- European Union-funded FP6 Integrated Project IMAGEN [LSHM-CT-2007-037286]
- FP7 projects [602450, 603016]
- Innovative Medicine Initiative Project EU-AIMS [115300-2]
- Medical Research Council programme grant [93558]
- NIHR Biomedical Research Center
- Swedish Research Council (FORMAS)
- BMBF (eMED SysAlc) [01ZX1311A, 1EV0711]
- BMBF through the Integrated Genome Research Network MooDS under the National Genome Research Network plus (NGFNplus) [01GS08144, 01GS08147, 01GS08148]
- Integrated Network IntegraMent, under the auspices of the e:Med Programme [01ZX1314A, 01ZX1314C, 01ZX1314G]
- Exzellenz-Stiftung of the Max Planck Society
- BMBF in the framework of the National Genome Research Network (NGFN) [FKZ 01GS0481]
- Bergen Research Foundation
- University of Bergen
- Dr Einar Martens Fund
- K. G. Jebsen Foundation and the Research Council of Norway
- Netherlands Organization for Scientific Research (Geestkracht program grant) [10-000-1002]
- Center for Medical Systems Biology (CSMB, NWO Genomics)
- Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL)
- VU University's Institutes for Health and Care Research (EMGO+)
- Neuroscience Campus Amsterdam
- University Medical Center Groningen, Leiden University Medical Center
- Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health
- NWO
- NWO large investment grant [1750102007010]
- Radboud University Nijmegen Medical Center
- University Medical Center Groningen and Accare
- VU University Amsterdam
- European Community's Seventh Framework Programme (FP7) [602450, 602805, 278948]
- NWO [MW904-61-193, MaGW-nr 400-07-080, MagW 480-04-004, 51.02.060, 668.772, NWO/SPI 56-464-14192]
- European Research Council [ERC-230374]
- Utrecht University
- NWO Brain and Cognition [433-09-220]
- Australian National Health and Medical Research Council (NHMRC)/Australian Research Council Strategic Award [401162]
- NHMRC [1045325, 310667, 401184, 525453, 568940, 389875, 486682, 1009064]
- Commonwealth Scientific and Industrial Research Organisation Flagship Collaboration Fund grant
- Australian Government
- Alzheimer's Australia Dementia Research Foundation
- National Science Foundation [BCS-1229450]
- Autism Speaks
- Australian Research Council [FT110100548, FT0991634]
- NHMRC fellowship [619667]
- BMBF (grants) [01ZZ9603, 01ZZ0103, 01ZZ0403]
- DFG [GR 1912/5-1]
- German Ministry of Cultural Affairs
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Siemens Healthcare, Erlangen, Germany
- Federal State of Mecklenburg-West Pomerania
- University Medicine Greifswald
- NHMRC program [401184, 350833, 568969]
- NHMRC project grant [525453]
- NHMRC capacity building grant [568940]
- The NIMH [R01 MH078075, MH065580, MH001760, RC2 MH089964, R01 MH084098, K01 MH085812, R01 MH100141, R01 MH077139, R01 MH095034, R01 MH062276, R01 MH068922, R01 MH068921, MH 41953, MH083094, K99MH102357]
- [CZ. 2.16/3.1.00/24022OPPK]
- [NT/13770-4]
- [00064203 FN Motol]
- [1RC2 MH089951]
- [1RC2 MH089995]
- [R01MH62873]
- [R01 NS080655]
- [R01AG040060]
- [R01 EB008432]
- [R01 MH097268]
- [R01 MH085667]
- [R01 MH089722]
- [ERC-2010-AdG 268800-NEUROSCHEMA]
- Australian Research Council [FT110100548, FT0991634] Funding Source: Australian Research Council
- Lundbeck Foundation [R155-2014-1724] Funding Source: researchfish
- Medical Research Council [G1100616, MR/L010305/1, MR/K026992/1, MR/L016400/1, G0000934, G0901858, G0800509, G0801418, MC_UU_12013/2, MC_UU_12013/1, MR/P005748/1, MR/L023784/2] Funding Source: researchfish
- Wellcome Trust [100309/A/12/Z] Funding Source: researchfish
- MRC [MR/L023784/2, MR/P005748/1, G0800509, G1100616, G0801418, MC_UU_12013/2, MR/L016400/1, G0000934, G0901858, MC_UU_12013/1] Funding Source: UKRI
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.
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