期刊
NATURE NEUROSCIENCE
卷 19, 期 12, 页码 1672-1681出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4403
关键词
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资金
- Burroughs-Wellcome Fund Career Award at the Scientific Interface
- Searle Scholars Program
- New York Stem Cell Foundation
- Alfred P. Sloan Research Foundation
- NARSAD Brain and Behavior Research Young Investigator Award
- NIH grant from the NIMH BRAINS program [R01MH107620, R01NS089521]
- NIH grant from NINDS [R01NS089521]
- Stuart H.Q. & Victoria Quan Fellowship
- NCRR [1S10RR028832-01]
We studied how the posterior parietal cortex combines new information with ongoing activity dynamics as mice accumulate evidence during a virtual navigation task. Using new methods to analyze population activity on single trials, we found that activity transitioned rapidly between different sets of active neurons. Each event in a trial, whether an evidence cue or a behavioral choice, caused seconds-long modifications to the probabilities that govern how one activity pattern transitions to the next, forming a short-term memory. A sequence of evidence cues triggered a chain of these modifications resulting in a signal for accumulated evidence. Multiple distinguishable activity patterns were possible for the same accumulated evidence because representations of ongoing events were influenced by previous within- and across-trial events. Therefore, evidence accumulation need not require the explicit competition between groups of neurons, as in winner-take-all models, but could instead emerge implicitly from general dynamical properties that instantiate short-term memory.
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