期刊
NATURE NEUROSCIENCE
卷 19, 期 8, 页码 999-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4331
关键词
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资金
- Swiss National Science Foundation [3100A0B-128657]
- European Research Council advanced grant (INSIGHT)
- Swiss National Science Foundation (SNF) [3100A0B-128657] Funding Source: Swiss National Science Foundation (SNF)
Feeding behavior is governed by homeostatic needs and motivational drive to obtain palatable foods. Here, we identify a population of glutamatergic neurons in the paraventricular thalamus of mice that express the glucose transporter Glut2 (encoded by Slc2a2) and project to the nucleus accumbens. These neurons are activated by hypoglycemia and, in freely moving mice, their activation by optogenetics or Slc2a2 inactivation increases motivated sucrose-seeking but not saccharin-seeking behavior. These neurons may control sugar overconsumption in obesity and diabetes.
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