期刊
NATURE NANOTECHNOLOGY
卷 11, 期 11, 页码 977-985出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nnano.2016.164
关键词
-
资金
- National Institutes of Health [R01GM111350, 1R01CA161280-01A1, 1U54 CA199081-01, R01GM113013, R01CA166413]
- Sloan Kettering Institute Core Grant [P30 CA008748CCSG]
- Benjamin Friedman Research Fund
The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (<10 nm in diameter) poly (ethylene glycol)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice. Tumour xenografts in mice intravenously injected with nanoparticles using a high-dose multiple injection scheme exhibit reduced growth or regression, in a manner that is reversed by the pharmacological inhibitor of ferroptosis, liproxstatin-1. These data demonstrate that ferroptosis can be targeted by ultrasmall silica nanoparticles and may have therapeutic potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据