期刊
NATURE NANOTECHNOLOGY
卷 11, 期 6, 页码 533-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2015.342
关键词
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资金
- Core Research Program for Evolutional Science and Technology (CREST)
- Center of Innovation (COI) Program from the Japan Science and Technology Corporation (JST)
- Japan Society for the Promotion of Science (JSPS), KAKENHI [2379004, 15K06871, 25750172, 24659584, 25000006]
- Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- Research Foundation for Pharmaceutical Sciences
- Photographic Research Fund of the Konica Minolta Imaging Science Foundation
- Initiative for Accelerating Regulatory Science in Innovative Drug, Medical Device, and Regenerative Medicine of the Ministry of Health, Labour and Welfare (MHLW) of Japan
- NIH [CA122356]
- Grants-in-Aid for Scientific Research [15K12534, 16K11226, 26670738, 15K06871, 26293119] Funding Source: KAKEN
Enhanced permeability in tumours is thought to result from malformed vascular walls with leaky cell-to-cell junctions(1,2). This assertion is backed by studies using electron microscopy and polymer casts that show incomplete pericyte coverage of tumour vessels and the presence of intercellular gaps(3). However, this gives the impression that tumour permeability is static amid a chaotic tumour environment. Using intravital confocal laser scanning microscopy(4,5) we show that the permeability of tumour blood vessels includes a dynamic phenomenon characterized by vascular bursts followed by brief vigorous outward flow of fluid (named 'eruptions') into the tumour interstitial space. We propose that 'dynamic vents' form transient openings and closings at these leaky blood vessels. These stochastic eruptions may explain the enhanced extravasation of nanoparticles from the tumour blood vessels, and offer insights into the underlying distribution patterns of an administered drug(6,7).
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